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Results for "

orexin

" in MCE Product Catalog:

By Targets:	Orexin Receptor (OX Receptor) (45) Amino Acid Derivatives (1) Apoptosis (3) Bacterial (1) Calcium Channel (2) Caspase (2) Endogenous Metabolite (1)
By Research Areas:	Cancer (6) Endocrinology (19) Inflammation/Immunology (1) Metabolic Disease (2) Neurological Disease (38)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Isotope-Labeled Compounds

Targets Recommended: Orexin Receptor (OX Receptor)

Cat. No.	Product Name	Target	Research Areas

HY-P1349

Orexin B, rat, mouse Rat orexin B; orexin B (mouse)	Orexin Receptor (OX Receptor)	Neurological Disease Endocrinology
Orexin B, rat, mouse (Rat orexin B) is an endogenous agonist at *Orexin* receptor with K_is of 420 and 36 nM for OX1 and OX2, respectively.

HY-P1339

Orexin B, human Human orexin B	Orexin Receptor (OX Receptor)	Neurological Disease Endocrinology
Orexin B, human is an endogenous agonist at *Orexin* receptor with K_is of 420 and 36 nM for OX1 and OX2, respectively.

HY-P1349A

Orexin B, rat, mouse TFA Rat orexin B TFA; orexin B (mouse) (TFA)	Orexin Receptor (OX Receptor)	Endocrinology Neurological Disease
Orexin B, rat, mouse (Rat orexin B) TFA is an endogenous orexin receptor agonist. Orexin B, rat, mouse TFA binds and activates two closely related orphan G protein-coupled receptors OX1-R and OX2-R. Orexin B, rat, mouse TFA stimulates food intake and energy expenditure and plays a significant role in sleep-wakefulness regulation.

HY-P1339A

Orexin B, human TFA Human orexin B TFA	Orexin Receptor (OX Receptor)	Neurological Disease Endocrinology
Orexin B, human (TFA) is an endogenous agonist at *Orexin* receptor with K_is of 420 and 36 nM for OX1 and OX2, respectively.

HY-138695

Orexin 2 Receptor Agonist 2	Orexin Receptor (OX Receptor)	Neurological Disease
Orexin 2 Receptor Agonist 2 is a selective orexin 2 receptor agonist, extracted from patent WO2017135306A1, example 16.

HY-136922

Orexin receptor antagonist 2	Orexin Receptor (OX Receptor)	Neurological Disease
Orexin receptor antagonist 2 (compound 30) is a potent orexin receptor antagonist with pK_is of 7.69 and 9.78. Orexin receptor antagonist 2 has the potential for the research of insomnia.

HY-137093

Orexin receptor antagonist 3	Orexin Receptor (OX Receptor)	Metabolic Disease
Orexin receptor antagonist 3 (example 216) is an orexin receptor antagonist, which is extracted from the patent WO2011050198A1.

HY-146517

Orexin receptor antagonist 4	Orexin Receptor (OX Receptor)	Neurological Disease
Orexin receptor antagonist 4 is potent and selective orexin 2 receptor (OX2R) antagonist with an IC₅₀ of 4.27 nM. Orexin receptor antagonist 4 is 61-fold selective for the OX2R over the OX1R (IC₅₀ of 295 nM) (WO2018206959A1; example 1).

HY-19320

Orexin 2 Receptor Agonist	Orexin Receptor (OX Receptor)	Neurological Disease Endocrinology
Orexin 2 Receptor Agonist is a potent (EC50 on OX2R is 23 nM) and OX2R-selective (OX1R/OX2R EC50 ratio is 70) agonist.

HY-106224

Orexin A (human, rat, mouse) Hypocretin-1 (human, rat, mouse)	Orexin Receptor (OX Receptor)	Neurological Disease
Orexin A (human, rat, mouse) (Hypocretin-1 (human, rat, mouse)), a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes. Orexin A (human, rat, mouse) is a specific, high-affinity agonist for G-protein-coupled receptor OX1R. Orexin A (human, rat, mouse) has a role in the regulation of feeding behavior. Orexin A (human, rat, mouse) is an effective anti-nociceptive and anti-hyperalgesic agent in mice and rats.

HY-106224A

Orexin A (human, rat, mouse) (TFA) Hypocretin-1 (human, rat, mouse) (TFA)	Orexin Receptor (OX Receptor)	Neurological Disease
Orexin A (human, rat, mouse) (Hypocretin-1 (human, rat, mouse)) TFA, a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes. Orexin A (human, rat, mouse) TFA is a specific, high-affinity agonist for G-protein-coupled receptor OX1R. Orexin A (human, rat, mouse) TFA has a role in the regulation of feeding behavior. Orexin A (human, rat, mouse) TFA is an effective anti-nociceptive and anti-hyperalgesic agent in mice and rats.

HY-106224B

Orexin A (human, rat, mouse) (acetate) Hypocretin-1 (human, rat, mouse) (acetate)	Orexin Receptor (OX Receptor)	Neurological Disease
Orexin A (Hypocretin-1) (human, rat, mouse) acetate is a hypothalamic neuropeptide with analgesic properties (crosses the blood-brain barrier). Orexin A (human, rat, mouse) acetate is also an OX1R agonist that induces the expression of BDNF and TH proteins in SH-SY5Y cells in a time- and dose-dependent manner. Orexin A (human, rat, mouse) acetate can be used in studies of appetite regulation, neurodegenerative diseases and modulation of injurious messaging.

HY-P1340

*[Ala11,D-Leu15]-Orexin* B(human)**	Orexin Receptor (OX Receptor)	Neurological Disease
[Ala11,D-Leu15]-Orexin B(human) is a potent and selective orexin-2 receptor (OX2) agonist. [Ala11,D-Leu15]-Orexin B(human) shows a 400-fold selectivity for the OX2 (EC₅₀=0.13 nM) over OX1 (52 nM).

HY-P1340A

*[Ala11,D-Leu15]-Orexin* B(human) TFA**	Orexin Receptor (OX Receptor)	Neurological Disease
[Ala11,D-Leu15]-Orexin B(human) TFA is a potent and selective orexin-2 receptor (OX2) agonist. [Ala11,D-Leu15]-Orexin B(human) TFA shows a 400-fold selectivity for the OX2 (EC₅₀=0.13 nM) over OX1 (52 nM).

HY-P1341

OXA(17-33)	Orexin Receptor (OX Receptor)	Neurological Disease
OXA(17-33) is a potent and selective orexin-1 receptor (OX1) agonist. OXA(17-33) shows a ∼23-fold selectivity for the OX1 (EC₅₀=8.29 nM) over OX2 (187 nM).

HY-101834

ACT-462206	Orexin Receptor (OX Receptor)	Others
ACT-462206 is an orally active and potent dual Orexin 1/Orexin 2 receptor antagonist with IC₅₀s of 60 nM (Orexin 1) and 11 nM (Orexin 2), respectively. ACT-462206 exhibits brain penetration properties, and can be used for insomnia, stress/anxiety-related disorders and addiction research.

HY-P1341A

OXA(17-33) TFA	Orexin Receptor (OX Receptor)	Neurological Disease
OXA(17-33) TFA is a potent and selective orexin-1 receptor (OX1) agonist. OXA(17-33) TFA shows a ∼23-fold selectivity for the OX1 (EC₅₀=8.29 nM) over OX2 (187 nM).

HY-10805A

Almorexant hydrochloride ACT 078573 hydrochloride	Orexin Receptor (OX Receptor) Calcium Channel Caspase Apoptosis	Cancer Endocrinology Neurological Disease
Almorexant (ACT 078573) hydrochloride is an orally active, potent and competitive dual orexin receptor antagonist, with K_d values of 1.3 nM (OX1) and 0.17 nM (OX2), respectively. Almorexant hydrochloride reversibly blocks signaling of orexin-A and orexin-B peptides. Almorexant hydrochloride totally blocked the intracellular Ca²⁺ signal pathway. Almorexant hydrochloride stimulates caspase-3 activity in AsPC-1 cells and induces apoptosis.

HY-10805

Almorexant ACT 078573	Orexin Receptor (OX Receptor) Calcium Channel Caspase Apoptosis	Cancer Endocrinology Neurological Disease
Almorexant (ACT 078573) is an orally active, potent and competitive dual orexin receptor antagonist, with K_d values of 1.3 nM (OX1) and 0.17 nM (OX2), respectively. Almorexant reversibly blocks signaling of orexin-A and orexin-B peptides. Almorexant totally blocked the intracellular Ca²⁺ signal pathway. Almorexant stimulates caspase-3 activity in AsPC-1 cells and induces apoptosis.

HY-108683

ACT-335827	Orexin Receptor (OX Receptor)	Neurological Disease
ACT-335827 is a selective, orally active, brain-penetrant orexin type 1 receptor antagonist. ACT-33582 acts on OXR1 and OXR2 with IC₅₀ values of 6 nM and 417 nM, respectively. ACT-33582 can be used in studies related to neurological disorders.

HY-10900

TCS 1102	Orexin Receptor (OX Receptor)	Neurological Disease Endocrinology
TCS 1102 is a potent, dual orexin receptor antagonist, with Ki values of 0.2 nM and 3 nM for OX2 and OX1 receptors, respectively. TCS 1102 demonstrates excellent brain peneration and moderate bioavailability in rats.

HY-10805S

Almorexant-13C,d3 ACT 078573-¹³C,d₃	Orexin Receptor (OX Receptor)	Neurological Disease Endocrinology
Almorexant-¹³C,d₃ is the ¹³C- and deuterium labeled Almorexant. Almorexant (ACT 078573) is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM, respectively.

HY-101534

GSK1059865
Orexin Receptor (OX Receptor) Neurological Disease Endocrinology

GSK1059865 is a potent orexin 1 receptor antagonist.
HY-147294

Nivasorexant
Orexin Receptor (OX Receptor) Neurological Disease

Nivasorexant is a potent orexin receptor antagonist.
HY-133898

Danavorexton
TAK-925
Orexin Receptor (OX Receptor) Others

Danavorexton (TAK-925) is an orexin receptor agonist.

GSK1059865	Orexin Receptor (OX Receptor)	Neurological Disease Endocrinology
GSK1059865 is a potent orexin 1 receptor antagonist.

Nivasorexant	Orexin Receptor (OX Receptor)	Neurological Disease
Nivasorexant is a potent orexin receptor antagonist.

Danavorexton TAK-925	Orexin Receptor (OX Receptor)	Others
Danavorexton (TAK-925) is an orexin receptor agonist.

HY-100452A

TCS-OX2-29 hydrochloride OX2R antagonist	Orexin Receptor (OX Receptor)	Cancer Endocrinology
TCS-OX2-29 (hydrochloride) is a potent, high affinities and selective orexin-2 receptor (OX₂R) antagonist with an IC₅₀ value of 40 nM and a pK_I value of 7.5. TCS-OX2-29 displays ~250-fold selectivity for OX₂ over OX₁.

HY-100452

TCS-OX2-29	Orexin Receptor (OX Receptor)	Cancer Endocrinology
TCS-OX2-29 is a potent, high affinities and selective orexin-2 receptor (OX₂R) antagonist with an IC₅₀ value of 40 nM and a pK_I value of 7.5. TCS-OX2-29 displays ~250-fold selectivity for OX₂ over OX₁.

HY-12301

MK-3697	Orexin Receptor (OX Receptor)	Neurological Disease Endocrinology
MK-3697 is an isonicotinamide small molecule, acting as a potent and selective Orexin 2 receptor antagonist with Ki = 0.95 nM.

HY-P3867

Hypocretin (70-98), human	Orexin Receptor (OX Receptor) Apoptosis	Cancer
Hypocretin (70-98), human is a polypeptide that is capable of binding to an orexin receptor OX1R and promotes apoptosis.

HY-152843

Fazamorexant
YZJ-1139
Orexin Receptor (OX Receptor) Neurological Disease

Fazamorexant (YZJ-1139) is a potent orexin receptor antagonist. Fazamorexant can be used for insomnia research.

Fazamorexant YZJ-1139	Orexin Receptor (OX Receptor)	Neurological Disease
Fazamorexant (YZJ-1139) is a potent orexin receptor antagonist. Fazamorexant can be used for insomnia research.

HY-P99911

Efizonerimod alfa	Orexin Receptor (OX Receptor)	Cancer Inflammation/Immunology
Efizonerimod alfa is a potent monoclonal antibody OX40 activator. Efizonerimod alfa can be used for cancer research.

HY-109012

Seltorexant JNJ-42847922	Orexin Receptor (OX Receptor)	Neurological Disease Endocrinology
Seltorexant (JNJ-42847922) is an orally active, high-affinity, and selective orexin-2 receptor (OX2R) antagonist (pK_i values of 8.0 and 8.1 for human and rat OX2R). Seltorexant (JNJ-42847922) crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brain.

HY-137452

Suntinorexton	Orexin Receptor (OX Receptor)	Neurological Disease
Suntinorexton, a heterocyclic compound, is an orexin type 2 receptor agonist extracted from patent WO2019027058A1, page 288.

HY-137440

Firazorexton
Orexin Receptor (OX Receptor) Neurological Disease

Firazorexton is a potent orexin type 2 receptor (OX2R) agonist (patent WO2019027058A1, example 395).

Firazorexton	Orexin Receptor (OX Receptor)	Neurological Disease
Firazorexton is a potent orexin type 2 receptor (OX2R) agonist (patent WO2019027058A1, example 395).

HY-134188

JNJ-54717793	Orexin Receptor (OX Receptor)	Neurological Disease
JNJ-54717793, as a brain penetrant, is an orally active, selective and high affinity orexin-1 receptor (OX1R) antagonist (plasma EC₅₀=85 ng/mL). The K_i values of JNJ-54717793 for hOX1R (human OX1R) and hOX2R are 16 nM and 700 nM, respectively. JNJ-54717793 is a potent compound of anxiety disorders.

HY-10806

SB-649868 GSK649868	Orexin Receptor (OX Receptor)	Metabolic Disease Endocrinology
SB-649868 is a potent and selective orally active *orexin* (OX) 1 and OX₂ receptor antagonist (pK_i =9.4 and 9.5 at the OX₁ and OX₂ receptor, respectively).

HY-10895

SB-334867 SB 334867A	Orexin Receptor (OX Receptor)	Neurological Disease Endocrinology
SB-334867 (SB 334867A) is an excellent,selective and blood–brain barrier permeable orexin-1 (OX1) receptor antagonist, shows selectivity over OX2 (pK_b=7.4), 100-fold over 5-HT_2B, 5-HT_2C with pK_i values of 5.4 and 5.3, respectively. SB-334867 reduces ethanol consumption and inhibits the acquisition of morphine-induced sensitization to locomotor activity in vivo.

HY-10895A

SB-334867 free base SB334867A free base	Orexin Receptor (OX Receptor)	Neurological Disease Endocrinology
SB-334867 free base (SB334867A free base) is an excellent, selective and blood–brain barrier permeable orexin-1 (OX1) receptor antagonist, shows selectivity over OX2 (pK_b=7.4), 100-fold over 5-HT_2B, 5-HT_2C with pK_i values of 5.4 and 5.3, respectively. SB-334867 reduces ethanol consumption and inhibits the acquisition of morphine-induced sensitization to locomotor activity in vivo.

HY-W048199

(S)-N-FMoc-2-(6'-heptenyl)alanine
Amino Acid Derivatives Others

(S)-N-FMoc-2-(6'-heptenyl)alanine is a amino acid, which can be used in peptide synthesis.

(S)-N-FMoc-2-(6'-heptenyl)alanine	Amino Acid Derivatives	Others
(S)-N-FMoc-2-(6'-heptenyl)alanine is a amino acid, which can be used in peptide synthesis.

HY-149014

OX2R-IN-1	Orexin Receptor (OX Receptor)	Neurological Disease
OX₂R-IN-1 (compound 15) is a low cytotoxicity profile OX₂R-IN-1 antagonist (a potential OX2R binder) with an IC₅₀ value of 484 μM. OX₂R-IN-1 (compound 15) can cross the BBB into the brain with a short half-life.

HY-10896

JNJ-10397049	Orexin Receptor (OX Receptor)	Neurological Disease
JNJ-10397049 is a potent and selective orexin 2 receptor (OX₂R) antagonist, with a pK_i of 8.3. JNJ-10397049 is 600-fold selective for the OX₂R over the OX₁R.

HY-108682

EMPA	Orexin Receptor (OX Receptor)	Neurological Disease
EMPA is a high-affinity, reversible and selective orexin OX₂ receptor antagonist. [³H]EMPA binds to human and rat OX₂-HEK293 membranes with K_D values of 1.1 and 1.4 nM respectively.

HY-76612

SB-408124 Hydrochloride	Orexin Receptor (OX Receptor)	Neurological Disease Endocrinology
SB-408124 Hydrochloride is a selective non-peptide orexin receptor 1 (OX1) receptor antagonist with K_is of 57 nM and 27 nM in whole cell and membrane, respectively. SB-408124 Hydrochloride exhibits 50-fold selectivity over OX2 receptor.

HY-10898

SB-674042	Orexin Receptor (OX Receptor)	Neurological Disease Endocrinology
SB-674042 is a potent and selective non-peptide orexin OX₁ receptor antagonist (K_d=5.03 nM), exhibits 100-fold selectivity for OX₁ over OX₂ receptors with IC₅₀ values of 3.76 nM and 531 nM, respectively.

HY-136181A

YNT-185	Orexin Receptor (OX Receptor)	Neurological Disease
YNT-185 is a nonpeptide, selective orexin type-2 receptor (OX2R) agonist, with EC₅₀s of 0.028 and 2.75 μM for OX2R and OX1R, respectively. YNT-185 ameliorates narcolepsy-cataplexy symptoms in mouse models.

HY-136181

YNT-185 dihydrochloride	Orexin Receptor (OX Receptor)	Neurological Disease
YNT-185 dihydrochloride is a nonpeptide, selective orexin type-2 receptor (OX2R) agonist, with EC₅₀s of 0.028 and 2.75 μM for OX2R and OX1R, respectively. YNT-185 dihydrochloride ameliorates narcolepsy-cataplexy symptoms in mouse models.

HY-128850

N-Acetyl-D-mannosamine N-Acetylmannosamine; ManNAc	Bacterial Endogenous Metabolite	Neurological Disease
N-Acetyl-D-mannosamine (ManNAc) is an essential precursor of N-acetylneuraminic acid (NeuAc), the specific monomer of bacterial capsular polysialic acid (PA). N-Acetyl-D-mannosamine (ManNAc) can be metabolized by GNE and GlcNAc 2-epimerase (Renin binding protein, RnBP), into ManNAc-6-phosphate and GlcNAc, respectively. N-Acetyl-d-mannosamine (ManNAc) and its derivatives activates hypocretin (HCRT) gene expression in the orexin neurons, providing a potential model for the testing of a therapy for neural disorders.

Cat. No.	Product Name	Target	Research Area

HY-P1349

Orexin B, rat, mouse Rat orexin B; orexin B (mouse)	Orexin Receptor (OX Receptor)	Neurological Disease Endocrinology
Orexin B, rat, mouse (Rat orexin B) is an endogenous agonist at *Orexin* receptor with K_is of 420 and 36 nM for OX1 and OX2, respectively.

HY-P1339

Orexin B, human Human orexin B	Orexin Receptor (OX Receptor)	Neurological Disease Endocrinology
Orexin B, human is an endogenous agonist at *Orexin* receptor with K_is of 420 and 36 nM for OX1 and OX2, respectively.

HY-P1349A

Orexin B, rat, mouse TFA Rat orexin B TFA; orexin B (mouse) (TFA)	Orexin Receptor (OX Receptor)	Endocrinology Neurological Disease
Orexin B, rat, mouse (Rat orexin B) TFA is an endogenous orexin receptor agonist. Orexin B, rat, mouse TFA binds and activates two closely related orphan G protein-coupled receptors OX1-R and OX2-R. Orexin B, rat, mouse TFA stimulates food intake and energy expenditure and plays a significant role in sleep-wakefulness regulation.

HY-P4792

Orexin A (16-33)
Peptides Others

Orexin A (16-33) is a fragment of orexin A.

HY-P1339A

Orexin B, human TFA Human orexin B TFA	Orexin Receptor (OX Receptor)	Neurological Disease Endocrinology
Orexin B, human (TFA) is an endogenous agonist at *Orexin* receptor with K_is of 420 and 36 nM for OX1 and OX2, respectively.

HY-106224

Orexin A (human, rat, mouse) Hypocretin-1 (human, rat, mouse)	Orexin Receptor (OX Receptor)	Neurological Disease
Orexin A (human, rat, mouse) (Hypocretin-1 (human, rat, mouse)), a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes. Orexin A (human, rat, mouse) is a specific, high-affinity agonist for G-protein-coupled receptor OX1R. Orexin A (human, rat, mouse) has a role in the regulation of feeding behavior. Orexin A (human, rat, mouse) is an effective anti-nociceptive and anti-hyperalgesic agent in mice and rats.

HY-106224A

Orexin A (human, rat, mouse) (TFA) Hypocretin-1 (human, rat, mouse) (TFA)	Orexin Receptor (OX Receptor)	Neurological Disease
Orexin A (human, rat, mouse) (Hypocretin-1 (human, rat, mouse)) TFA, a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes. Orexin A (human, rat, mouse) TFA is a specific, high-affinity agonist for G-protein-coupled receptor OX1R. Orexin A (human, rat, mouse) TFA has a role in the regulation of feeding behavior. Orexin A (human, rat, mouse) TFA is an effective anti-nociceptive and anti-hyperalgesic agent in mice and rats.

HY-106224B

Orexin A (human, rat, mouse) (acetate) Hypocretin-1 (human, rat, mouse) (acetate)	Orexin Receptor (OX Receptor)	Neurological Disease
Orexin A (Hypocretin-1) (human, rat, mouse) acetate is a hypothalamic neuropeptide with analgesic properties (crosses the blood-brain barrier). Orexin A (human, rat, mouse) acetate is also an OX1R agonist that induces the expression of BDNF and TH proteins in SH-SY5Y cells in a time- and dose-dependent manner. Orexin A (human, rat, mouse) acetate can be used in studies of appetite regulation, neurodegenerative diseases and modulation of injurious messaging.

HY-P4791

Orexin A (1-15) (free acid)	Peptides	Others
Orexin A (1-15) (free acid) is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development.

HY-P1340

*[Ala11,D-Leu15]-Orexin* B(human)**	Orexin Receptor (OX Receptor)	Neurological Disease
[Ala11,D-Leu15]-Orexin B(human) is a potent and selective orexin-2 receptor (OX2) agonist. [Ala11,D-Leu15]-Orexin B(human) shows a 400-fold selectivity for the OX2 (EC₅₀=0.13 nM) over OX1 (52 nM).

HY-P1340A

*[Ala11,D-Leu15]-Orexin* B(human) TFA**	Orexin Receptor (OX Receptor)	Neurological Disease
[Ala11,D-Leu15]-Orexin B(human) TFA is a potent and selective orexin-2 receptor (OX2) agonist. [Ala11,D-Leu15]-Orexin B(human) TFA shows a 400-fold selectivity for the OX2 (EC₅₀=0.13 nM) over OX1 (52 nM).

HY-P4929

*Biotinyl-(Gln1)-Orexin* A (human, mouse, rat)**	Peptides	Others
Biotinyl-(Gln1)-Orexin A (human, mouse, rat) is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development.

HY-P4398

*(Cys(Acm)6,12)-Orexin* A (human, mouse, rat)**	Peptides	Others
(Cys(Acm)6,12)-Orexin A (human, mouse, rat) is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development.

HY-P1341

OXA(17-33)	Orexin Receptor (OX Receptor)	Neurological Disease
OXA(17-33) is a potent and selective orexin-1 receptor (OX1) agonist. OXA(17-33) shows a ∼23-fold selectivity for the OX1 (EC₅₀=8.29 nM) over OX2 (187 nM).

HY-P1341A

OXA(17-33) TFA	Orexin Receptor (OX Receptor)	Neurological Disease
OXA(17-33) TFA is a potent and selective orexin-1 receptor (OX1) agonist. OXA(17-33) TFA shows a ∼23-fold selectivity for the OX1 (EC₅₀=8.29 nM) over OX2 (187 nM).

HY-P3867

Hypocretin (70-98), human	Orexin Receptor (OX Receptor) Apoptosis	Cancer
Hypocretin (70-98), human is a polypeptide that is capable of binding to an orexin receptor OX1R and promotes apoptosis.

HY-W048199

(S)-N-FMoc-2-(6'-heptenyl)alanine
Amino Acid Derivatives Others

(S)-N-FMoc-2-(6'-heptenyl)alanine is a amino acid, which can be used in peptide synthesis.

Cat. No.	Product Name	Target	Research Area

HY-P99911

Efizonerimod alfa	Orexin Receptor (OX Receptor)	Cancer Inflammation/Immunology
Efizonerimod alfa is a potent monoclonal antibody OX40 activator. Efizonerimod alfa can be used for cancer research.

Cat. No.	Product Name

HY-10805S

Almorexant-13C,d3
Almorexant-¹³C,d₃ is the ¹³C- and deuterium labeled Almorexant. Almorexant (ACT 078573) is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM, respectively.