1. GPCR/G Protein
  2. Orexin Receptor (OX Receptor)

Orexin B, human (Synonyms: Human orexin B)

Cat. No.: HY-P1339
Handling Instructions

Orexin B, human is an endogenous agonist at Orexin receptor with Kis of 420 and 36 nM for OX1 and OX2, respectively.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Orexin B, human Chemical Structure

Orexin B, human Chemical Structure

CAS No. : 205640-91-1

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Orexin B, human is an endogenous agonist at Orexin receptor with Kis of 420 and 36 nM for OX1 and OX2, respectively.

IC50 & Target

Ki: 420 nM (OX1), 36 nM (OX2)[1]

In Vitro

Orexin B is derived by proteolytic amino acid precursor, prepro-orexin, which is encoded by a gene localized to chromosome 17q21 in humans. In radioligand binding studies, Orexin B has a higher affinity for the OX2 receptor[1]. Human Orexin B has two amino acid substitutions when compared with the rodent sequence. OX2 receptor is indeed a high-affinity receptor for human orexin B, with an IC50 of 36 nM in the binding assay and an EC50 of 60 nM in the [Ca2+]i transient assay. Human Orexin B has significantly lower affinity for the human OX1: the calculated IC50 in the competitive binding assay and the EC50 in the [Ca2+]i transient assay are 420 nM and 2500 nM for human orexin-B, respectively[2].

In Vivo

Human Orexin B significantly augments food intake; at the 2 hr time point, 5- and 12-fold stimulation of food consumption is observed by 3 nM and 30 nM orexin-B, respectively[2].

References
Animal Administration
[2]

Rats[2]

3 nM and 30 nM of synthetic human Orexin B is administered in a 5 mL bolus through a catheter placed in the left lateral ventricle of Male Wistar rats (180–200 g) in early light phase. Cumulative food consumption is observed and plotted over the period of 4 hr after injection[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

2899.34

Formula

C₁₂₃H₂₁₂N₄₄O₃₅S

CAS No.

205640-91-1

Sequence

Arg-Ser-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Ala-Ser-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2

Sequence Shortening

RSGPPGLQGRLQRLLQASGNHAAGILTM-NH2

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Orexin B, human
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HY-P1339
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Orexin B, human

Cat. No.: HY-P1339