Orexin B, human
Based on 2 publication(s) in Google Scholar
Orexin B, human is an endogenous agonist at Orexin receptor with Kis of 420 and 36 nM for OX1 and OX2, respectively.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 205640-91-1
- Formule: C123H212N44O35S
- Masse moléculaire:2899.34
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
- Pureté et documentation
- Références
-
Help & FAQs
-
HY-106224
Orexin A (human, rat, mouse)Orexin Receptor Agonist -
HY-P1349
Orexin B, rat, mouseOrexin Receptor Agonist -
HY-10895
SB-334867OX1 Receptor Antagonist -
HY-100452
TCS-OX2-29OX2R Antagonist -
HY-15653
FilorexantOX Receptor Antagonist -
HY-70068
SB-408124OX1 Receptor Antagonist -
HY-10805A
Almorexant hydrochlorideOrexin Receptor Antagonist -
HY-19320
Orexin 2 Receptor AgonistOX2R Agonist -
HY-19914
MK-1064OX2R Antagonist -
HY-10900
TCS 1102OX Receptor Antagonist -
HY-109012
SeltorexantOrexin-2 Receptor Antagonist -
HY-10898
SB-674042OX1 Receptor Antagonist
Publications Citing Use of MedChemExpress (MCE) Orexin B, human
MoreVoir tous les produits spécifiques à Isoform Orexin Receptor (OX Receptor)
More
Activité biologique
Description
IC50 & Target
Ki: 420 nM (OX1), 36 nM (OX2)[1]
In Vitro
Orexin B is derived by proteolytic amino acid precursor, prepro-orexin, which is encoded by a gene localized to chromosome 17q21 in humans. In radioligand binding studies, Orexin B has a higher affinity for the OX2 receptor[1]. Human Orexin B has two amino acid substitutions when compared with the rodent sequence. OX2 receptor is indeed a high-affinity receptor for human orexin B, with an IC50 of 36 nM in the binding assay and an EC50 of 60 nM in the [Ca2+]i transient assay. Human Orexin B has significantly lower affinity for the human OX1: the calculated IC50 in the competitive binding assay and the EC50 in the [Ca2+]i transient assay are 420 nM and 2500 nM for human orexin-B, respectively[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 205640-91-1
-
Masse moléculaire 2899.34
-
Formule C123H212N44O35S
-
Synonyms
Human orexin B
-
Sequence
Arg-Ser-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Ala-Ser-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2
-
Sequence Shortening
RSGPPGLQGRLQRLLQASGNHAAGILTM-NH2
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
-
Journal Impact Factor
-
Most Recent
-
J Neuroinflammation
SARS-CoV-2 infection is associated with hypothalamic orexin suppression and persistent cortical NeuN attenuation. [Abstract]2026 May 5;23(1):216. PMID: 42087199 -
Pureté et documentation
Références
[1]. Smart D, et al. Orexins: a new family of neuropeptides. Br J Anaesth. 1999 Nov;83(5):695-7. [Content Brief]
[2]. Sakurai T, et al. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell. 1998 Feb 20;92(4):573-85. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Orexin B, human Related Classifications
HY-P1339 Related Classifications
Powered by Bioz