Orexin B, human
Based on 2 publication(s) in Google Scholar
Orexin B, human is an endogenous agonist at Orexin receptor with Kis of 420 and 36 nM for OX1 and OX2, respectively.
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- CAS. Nr.: 205640-91-1
- Formel: C123H212N44O35S
- Molecular Weight:2899.34
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Speicherung:
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Publications Citing Use of MedChemExpress (MCE) Orexin B, human
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Biologische Aktivität
Beschreibung
IC50 & Target
Ki: 420 nM (OX1), 36 nM (OX2)[1]
In Vitro
Orexin B is derived by proteolytic amino acid precursor, prepro-orexin, which is encoded by a gene localized to chromosome 17q21 in humans. In radioligand binding studies, Orexin B has a higher affinity for the OX2 receptor[1]. Human Orexin B has two amino acid substitutions when compared with the rodent sequence. OX2 receptor is indeed a high-affinity receptor for human orexin B, with an IC50 of 36 nM in the binding assay and an EC50 of 60 nM in the [Ca2+]i transient assay. Human Orexin B has significantly lower affinity for the human OX1: the calculated IC50 in the competitive binding assay and the EC50 in the [Ca2+]i transient assay are 420 nM and 2500 nM for human orexin-B, respectively[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 205640-91-1
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Molecular Weight 2899.34
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Formel C123H212N44O35S
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Synonyms
Human orexin B
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Sequence
Arg-Ser-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Ala-Ser-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2
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Sequence Shortening
RSGPPGLQGRLQRLLQASGNHAAGILTM-NH2
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
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Journal Impact Factor
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Most Recent
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J Neuroinflammation
SARS-CoV-2 infection is associated with hypothalamic orexin suppression and persistent cortical NeuN attenuation. [Abstract]2026 May 5;23(1):216. PMID: 42087199 -
Reinheit & Dokumentation
Verweise
[1]. Smart D, et al. Orexins: a new family of neuropeptides. Br J Anaesth. 1999 Nov;83(5):695-7. [Content Brief]
[2]. Sakurai T, et al. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell. 1998 Feb 20;92(4):573-85. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Orexin B, human Related Classifications
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