2. GPCR/G Protein
    Neuronal Signaling
  3. Orexin Receptor (OX Receptor)
  4. Orexin receptor antagonist 2

Orexin receptor antagonist 2 

Cat. No.: HY-136922 Purity: 98.04%
COA Handling Instructions

Orexin receptor antagonist 2 (compound 30) is a potent orexin receptor antagonist with pKis of 7.69 and 9.78. Orexin receptor antagonist 2 has the potential for the research of insomnia.

For research use only. We do not sell to patients.

Orexin receptor antagonist 2 Chemical Structure

Orexin receptor antagonist 2 Chemical Structure

CAS No. : 1457940-75-8

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 550 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 550 In-stock
Solid
5 mg USD 500 In-stock
10 mg USD 850 In-stock
25 mg USD 1800 In-stock
50 mg USD 3000 In-stock
100 mg   Get quote  
200 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Orexin receptor antagonist 2 (compound 30) is a potent orexin receptor antagonist with pKis of 7.69 and 9.78. Orexin receptor antagonist 2 has the potential for the research of insomnia[1].

Molecular Weight

433.55

Appearance

Solid

Formula

C25H31N5O2
CAS No.
SMILES

O=C1N(CC2=CNC3=C2C=C(OC)C=C3)CCCC14CCN(C5=NC(C)=CC(C)=N5)CC4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (144.16 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3065 mL 11.5327 mL 23.0654 mL
5 mM 0.4613 mL 2.3065 mL 4.6131 mL
10 mM 0.2307 mL 1.1533 mL 2.3065 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.80 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.80 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Keywords:

Orexin receptor antagonist 21457940-75-8Orexin receptor antagonist2Orexin receptor antagonist-2Orexin Receptor (OX Receptor)Hypocretin ReceptorHCRT ReceptorinsomniaNREMsleepInhibitorinhibitorinhibit

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Orexin receptor antagonist 2
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