1. GPCR/G Protein
    Neuronal Signaling
  2. Orexin Receptor (OX Receptor)
  3. Seltorexant

Seltorexant (Synonyms: JNJ-42847922)

Cat. No.: HY-109012
Handling Instructions

Seltorexant (JNJ-42847922) is an orally active, high-affinity, and selective OX2R antagonist (pKi values of 8.0 and 8.1 for human and rat OX2R). Seltorexant (JNJ-42847922) crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brain.

For research use only. We do not sell to patients.

Seltorexant Chemical Structure

Seltorexant Chemical Structure

CAS No. : 1293281-49-8

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Description

Seltorexant (JNJ-42847922) is an orally active, high-affinity, and selective OX2R antagonist (pKi values of 8.0 and 8.1 for human and rat OX2R). Seltorexant (JNJ-42847922) crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brain[1].

IC50 & Target

pKi: 8.0 (human OX2R), 8.1 (rat OX2R)[1]

Molecular Weight

407.44

Formula

C₂₁H₂₂FN₇O

CAS No.

1293281-49-8

SMILES

O=C(N1CC(CN(C2=NC(C)=CC(C)=N2)C3)C3C1)C4=C(N5N=CC=N5)C=CC=C4F

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Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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