1. GPCR/G Protein
    Neuronal Signaling
  2. Orexin Receptor (OX Receptor)
  3. Vornorexant

Vornorexant (Synonyms: ORN-0829; TS-142)

Cat. No.: HY-139559
Handling Instructions

Vornorexant (ORN-0829; TS-142) is a potent dual OX1R and OX2R antagonist with IC50 values of 1.05 nM and 1.27 nM, respectively. Vornorexant exhibits potent sleep-promoting effects in vivo and can be used for insomnia treatment research.

For research use only. We do not sell to patients.

Vornorexant Chemical Structure

Vornorexant Chemical Structure

CAS No. : 1517965-94-4

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Description

Vornorexant (ORN-0829; TS-142) is a potent dual OX1R and OX2R antagonist with IC50 values of 1.05 nM and 1.27 nM, respectively. Vornorexant exhibits potent sleep-promoting effects in vivo and can be used for insomnia treatment research[1].

In Vivo

Vornorexant (oral administration; 1-10 mg/kg) exhibits potent sleep-promoting effects at a po. dose of 1 mg/kg in a rat polysomnogram study. It results in a dose-dependent increase in the percentage of total sleep[1].
Vornorexant exhibits optimal PK properties with a rapid Tmax and short half-lives in rats and dogs. The T1/2 is 0.238 hours and 1.16 hours, respectively in rat and dog[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rat[1]
Dosage: 1, 3, 10 mg/kg
Administration: Oral administration to rats prior to turning the light off (start of the active phase); 1-10 mg/kg
Result: Possessed promising sleep-inducing and sleep-promoting effects.
Molecular Weight

447.46

Formula

C₂₃H₂₂FN₇O₂

CAS No.
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