1. GPCR/G Protein Neuronal Signaling
  2. Orexin Receptor (OX Receptor)
  3. Danavorexton

Danavorexton  (Synonyms: TAK-925)

Cat. No.: HY-133898 Purity: 98.36%
COA Handling Instructions

Danavorexton (TAK-925) is an orexin receptor agonist with brain permeability. Danavorexton induces a physiological pattern of OX2R activation in vitro to wake up sleepy mice and improve sleepiness symptoms.

For research use only. We do not sell to patients.

Danavorexton Chemical Structure

Danavorexton Chemical Structure

CAS No. : 2114324-48-8

Size Price Stock Quantity
5 mg USD 780 In-stock
10 mg USD 1250 In-stock
25 mg USD 2580 In-stock
50 mg USD 4000 In-stock
100 mg USD 6400 In-stock
200 mg   Get quote  
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Customer Review

Based on 1 publication(s) in Google Scholar

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  • Biological Activity

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Description

Danavorexton (TAK-925) is an orexin receptor agonist with brain permeability. Danavorexton induces a physiological pattern of OX2R activation in vitro to wake up sleepy mice and improve sleepiness symptoms[1][2][3][4].

In Vivo

Danavorexton (1, 10 mg/kg or 1, 3 mg/kg, subcutaneous injection) dose-dependent enhanced arousal in common marmosets and cynomolgus monkeys[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Common marmosets and cynomolgus monkeys models[2]
Dosage: 1, 10 mg/kg (1, 3 mg/kg)
Administration: s.c.
Result: Decreased SWS I (Sleeping With Sirens I), SWS II (Sleeping With Sirens II) and REM (Rapid Eye Movement) sleep time.
Clinical Trial
Molecular Weight

424.55

Formula

C21H32N2O5S

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N1[C@@H](CO[C@H]2CC[C@@H](C3=CC=CC=C3)CC2)[C@@H](NS(=O)(C)=O)CCC1)OC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (117.77 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3554 mL 11.7772 mL 23.5544 mL
5 mM 0.4711 mL 2.3554 mL 4.7109 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.36%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3554 mL 11.7772 mL 23.5544 mL 58.8859 mL
5 mM 0.4711 mL 2.3554 mL 4.7109 mL 11.7772 mL
10 mM 0.2355 mL 1.1777 mL 2.3554 mL 5.8886 mL
15 mM 0.1570 mL 0.7851 mL 1.5703 mL 3.9257 mL
20 mM 0.1178 mL 0.5889 mL 1.1777 mL 2.9443 mL
25 mM 0.0942 mL 0.4711 mL 0.9422 mL 2.3554 mL
30 mM 0.0785 mL 0.3926 mL 0.7851 mL 1.9629 mL
40 mM 0.0589 mL 0.2944 mL 0.5889 mL 1.4721 mL
50 mM 0.0471 mL 0.2355 mL 0.4711 mL 1.1777 mL
60 mM 0.0393 mL 0.1963 mL 0.3926 mL 0.9814 mL
80 mM 0.0294 mL 0.1472 mL 0.2944 mL 0.7361 mL
100 mM 0.0236 mL 0.1178 mL 0.2355 mL 0.5889 mL
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Danavorexton Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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