2114324-48-8
2114324-48-8
Chemical Structure
Danavorexton
Synonym(s): TAK-925
- CAS No.: 2114324-48-8
- Formula:C21H32N2O5S
- Molecular Weight:424.55
IUPAC Name: methyl (2R,3S)-3-(methylsulfonamido)-2-((((1s,4S)-4-phenylcyclohexyl)oxy)methyl)piperidine-1-carboxylate
InChIKey: UXZAJSZFFARTEI-YRPNKDGESA-N
SMILES: O=C(N1[C@@H](CO[C@H]2CC[C@@H](C3=CC=CC=C3)CC2)[C@@H](NS(=O)(C)=O)CCC1)OC
Biological Activity: Danavorexton (TAK-925) is an orexin receptor agonist with brain permeability. Danavorexton induces a physiological pattern of OX2R activation in vitro to wake up sleepy mice and improve sleepiness symptoms[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Danavorexton | 99.56% | Danavorexton (TAK-925) is an orexin receptor agonist with brain permeability. Danavorexton induces a physiological pattern of OX2R activation in vitro to wake up sleepy mice and improve sleepiness symptoms. | ||||||||||||||||||||
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References
- [1]. International Nonproprietary Names for Pharmaceutical Substances (INN). WHO Drug Information, Vol. 34, No. 2, 2020.
- [2]. Evans R, et al. Orexin 2 receptor-selective agonist danavorexton (TAK-925) promotes wakefulness in non-human primates and healthy individuals. J Sleep Res. 2023 Oct;32(5):e13878 [Content Brief]
- [3]. Ishikawa T, et al. Danavorexton, a selective orexin 2 receptor agonist, provides a symptomatic improvement in a narcolepsy mouse model. Pharmacol Biochem Behav. 2022 Oct;220:173464. [Content Brief]
- [4]. Fujimoto T, et al. Discovery of TAK-925 as a Potent, Selective, and Brain-Penetrant Orexin 2 Receptor Agonist. ACS Med Chem Lett. 2022 Feb 4;13(3):457-462. [Content Brief]
Keywords
