1. GPCR/G Protein
    Neuronal Signaling
  2. Orexin Receptor (OX Receptor)
  3. SB-408124

SB-408124 

Cat. No.: HY-70068 Purity: 98.87%
Handling Instructions

SB-408124 is a non-peptide OX1 receptor antagonist with Kis of 57 nM and 27 nM in whole cell and membrane, respectively. SB-408124 exhibits 50-fold selectivity over OX2 receptor.

For research use only. We do not sell to patients.

SB-408124 Chemical Structure

SB-408124 Chemical Structure

CAS No. : 288150-92-5

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 68 In-stock
Estimated Time of Arrival: December 31
5 mg USD 62 In-stock
Estimated Time of Arrival: December 31
10 mg USD 113 In-stock
Estimated Time of Arrival: December 31
100 mg USD 727 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Description

SB-408124 is a non-peptide OX1 receptor antagonist with Kis of 57 nM and 27 nM in whole cell and membrane, respectively. SB-408124 exhibits 50-fold selectivity over OX2 receptor[1].

IC50 & Target[1]

OX1 Receptor

57 nM (Ki, in whole cell )

OX1 Receptor

27 nM (Ki, in cell membrane)

In Vivo

SB-408124 (30 μg/10 μl; i.c.v.; male Wistar rats) decreases Orexin-A induced water intake in Wistar rats[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

356.37

Formula

C₁₉H₁₈F₂N₄O

CAS No.

288150-92-5

SMILES

O=C(NC1=CC(C)=NC2=C(C=C(C=C21)F)F)NC3=CC=C(C=C3)N(C)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (140.30 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8061 mL 14.0304 mL 28.0607 mL
5 mM 0.5612 mL 2.8061 mL 5.6121 mL
10 mM 0.2806 mL 1.4030 mL 2.8061 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (7.02 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 98.87%

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Keywords:

SB-408124SB408124SB 408124Orexin Receptor (OX Receptor)Hypocretin ReceptorHCRT ReceptorcellmembraneselectivitywaterintakeInhibitorinhibitorinhibit

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Product Name:
SB-408124
Cat. No.:
HY-70068
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