2. Anti-infection
    Metabolic Enzyme/Protease
  3. Bacterial
    Endogenous Metabolite
  4. N-Acetyl-D-mannosamine

N-Acetyl-D-mannosamine  (Synonyms: N-Acetylmannosamine; ManNAc)

Cat. No.: HY-128850 Purity: 99.89%
COA Handling Instructions

N-Acetyl-D-mannosamine (ManNAc) is an essential precursor of N-acetylneuraminic acid (NeuAc), the specific monomer of bacterial capsular polysialic acid (PA). N-Acetyl-D-mannosamine (ManNAc) can be metabolized by GNE and GlcNAc 2-epimerase (Renin binding protein, RnBP), into ManNAc-6-phosphate and GlcNAc, respectively.  N-Acetyl-d-mannosamine (ManNAc) and its derivatives activates hypocretin (HCRT) gene expression in the orexin neurons, providing a potential model for the testing of a therapy for neural disorders.

For research use only. We do not sell to patients.

N-Acetyl-D-mannosamine Chemical Structure

N-Acetyl-D-mannosamine Chemical Structure

CAS No. : 3615-17-6

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Based on 1 publication(s) in Google Scholar

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Description

N-Acetyl-D-mannosamine (ManNAc) is an essential precursor of N-acetylneuraminic acid (NeuAc), the specific monomer of bacterial capsular polysialic acid (PA)[1]. N-Acetyl-D-mannosamine (ManNAc) can be metabolized by GNE and GlcNAc 2-epimerase (Renin binding protein, RnBP), into ManNAc-6-phosphate and GlcNAc, respectively.  N-Acetyl-d-mannosamine (ManNAc) and its derivatives activates hypocretin (HCRT) gene expression in the orexin neurons, providing a potential model for the testing of a therapy for neural disorders[2].

IC50 & Target

Human Endogenous Metabolite

 

Molecular Weight

221.21

Appearance

Solid

Formula

C8H15NO6
CAS No.
SMILES
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
In Vitro: 

H2O : 125 mg/mL (565.07 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.5206 mL 22.6030 mL 45.2059 mL
5 mM 0.9041 mL 4.5206 mL 9.0412 mL
10 mM 0.4521 mL 2.2603 mL 4.5206 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 25 mg/mL (113.01 mM); Clear solution; Need ultrasonic

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Keywords:

N-Acetyl-D-mannosamine3615-17-6N-Acetylmannosamine ManNAcBacterialEndogenous MetaboliteInhibitorinhibitorinhibit

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