2. Recombinant Proteins
  3. Receptor Proteins
  4. OX1R Protein, Human (HEK293, FLAG, His)

OX1R Protein, Human (HEK293, FLAG, His)

Cat. No.: HY-P701836
Handling Instructions

OX1R, a moderately selective excitatory receptor, binds orexin-A and orexin-B neuropeptides. Upon orexin-A binding, OX1R activates cellular events, elevating cytoplasmic Ca(2+) levels. This interaction positions OX1R as a mediator in orexin neuropeptide signaling, influencing intracellular calcium dynamics in response to orexin-A. OX1R Protein, Human (HEK293, FLAG, His) is the recombinant human-derived OX1R protein, expressed by HEK293 , with C-10*His, N-Flag labeled tag. ,

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Description

OX1R, a moderately selective excitatory receptor, binds orexin-A and orexin-B neuropeptides. Upon orexin-A binding, OX1R activates cellular events, elevating cytoplasmic Ca(2+) levels. This interaction positions OX1R as a mediator in orexin neuropeptide signaling, influencing intracellular calcium dynamics in response to orexin-A. OX1R Protein, Human (HEK293, FLAG, His) is the recombinant human-derived OX1R protein, expressed by HEK293 , with C-10*His, N-Flag labeled tag. ,
Background

OX1R, a moderately selective excitatory receptor, demonstrates an affinity for both orexin-A and orexin-B neuropeptides. Upon binding with orexin-A, OX1R initiates a cascade of cellular events, leading to an elevation in cytoplasmic Ca(2+) levels. This interaction highlights OX1R's role as a mediator in orexin neuropeptide signaling, contributing to the modulation of intracellular calcium dynamics in response to orexin-A binding.
Species

Human
Source

HEK293
Tag

C-10*His;N-Flag
Accession

O43613
Gene ID

3061
Molecular Construction
N-term
Flag

Accession # O43613
10*His OX1R
C-term
Synonyms
HCRTR1; Orexin/Hypocretin receptor type 1; Hypocretin receptor type 1; Orexin receptor type 1; Ox-1-R; Ox1-R; Ox1R
Purity

Greater than 90% as determined by reducing SDS-PAGE.
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

OX1R Protein, Human (HEK293, FLAG, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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