1. GPCR/G Protein
    Neuronal Signaling
  2. Orexin Receptor (OX Receptor)
  3. Almorexant hydrochloride

Almorexant hydrochloride (Synonyms: ACT-078573 hydrochloride)

Cat. No.: HY-10805A Purity: 99.88%
Handling Instructions

Almorexant hydrochloride (ACT 078573 hydrochloride) is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM, respectively.

For research use only. We do not sell to patients.

Almorexant hydrochloride Chemical Structure

Almorexant hydrochloride Chemical Structure

CAS No. : 913358-93-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 174 In-stock
Estimated Time of Arrival: December 31
5 mg USD 144 In-stock
Estimated Time of Arrival: December 31
10 mg USD 240 In-stock
Estimated Time of Arrival: December 31
50 mg USD 828 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1440 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 3 publication(s) in Google Scholar

Other Forms of Almorexant hydrochloride:

Top Publications Citing Use of Products

    Almorexant hydrochloride purchased from MCE. Usage Cited in: Oncotarget. 2018 Jan 9;9(6):6952-6967.

    Orexin-A and Almorexant promote tyrosine phosphorylation of SHP2/OX1R complex
    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Almorexant hydrochloride (ACT 078573 hydrochloride) is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM, respectively.

    IC50 & Target

    IC50: 1.3/0.7 nM(OX1/OX2 receptor)

    Clinical Trial
    Molecular Weight

    549.02

    Formula

    C₂₉H₃₂ClF₃N₂O₃

    CAS No.

    913358-93-7

    SMILES

    CNC([[email protected]@H](C1=CC=CC=C1)N2CCC3=CC(OC)=C(OC)C=C3[[email protected]@H]2CCC4=CC=C(C(F)(F)F)C=C4)=O.Cl

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 46 mg/mL (83.79 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.8214 mL 9.1071 mL 18.2143 mL
    5 mM 0.3643 mL 1.8214 mL 3.6429 mL
    10 mM 0.1821 mL 0.9107 mL 1.8214 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (4.55 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (4.55 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (4.55 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References

    Purity: 99.88%

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    Product name:
    Almorexant hydrochloride
    Cat. No.:
    HY-10805A
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