YNT-185 dihydrochloride
Based on 1 publication(s) in Google Scholar
YNT-185 dihydrochloride is a nonpeptide, selective orexin type-2 receptor (OX2R) agonist, with EC50s of 0.028 and 2.75 μM for OX2R and OX1R, respectively. YNT-185 dihydrochloride ameliorates narcolepsy-cataplexy symptoms in mouse models.
For research use only. We do not sell to patients.
- Purity: 99.78%
- CAS No.: 1804978-82-2
- Formula: C33H39Cl2N5O5S
- Molecular Weight:688.66
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) YNT-185 dihydrochloride
MoreAll Orexin Receptor (OX Receptor) Isoforms
More
Biological Activity
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OX2 Receptor 0.028 μM (EC50) |
OX1 Receptor 2.75 μM (EC50) |
YNT-185 dihydrochloride (300 nmol; i.c.v.) significantly increases wake time for 3 hours in a dose-dependent manner, accompanied by a decrease in NREM sleep time, in wild-type mice but not in OXRDKO mice[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male wild-type C57BL/6J mice[2]
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Dosage:20, 40 mg/kg
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Administration:I.p.
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Result:Wake time was also significantly increased.
Chemical Information
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CAS No. 1804978-82-2
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Appearance Solid
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Molecular Weight 688.66
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Formula C33H39Cl2N5O5S
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Color Off-white to light yellow
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SMILES
O=[S](NC1=CC(NCCNC(C(C=CC=C2)=C2N(C)C)=O)=CC=C1)(C(C=C(C3=CC(C(N(C)C)=O)=CC=C3)C=C4)=C4OC)=O.Cl.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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Brain Res
2025 Jul 15:1859:149646. PMID: 40246189
Solvent & Solubility
DMSO : 125 mg/mL (181.51 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 100 mg/mL (145.21 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: Saline
Solubility: 12.5 mg/mL (18.15 mM); Clear solution; Need ultrasonic and warming and heat to 60°C
Purity & Documentation
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Nagahara T, et al. Design and Synthesis of Non-Peptide, Selective Orexin Receptor 2 Agonists. J Med Chem. 2015;58(20):7931-7937. [Content Brief]
[2]. Irukayama-Tomobe Y, et al. Nonpeptide orexin type-2 receptor agonist ameliorates narcolepsy-cataplexy symptoms in mouse models. Proc Natl Acad Sci U S A. 2017;114(22):5731-5736. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 1.4521 mL | 7.2605 mL | 14.5210 mL | 36.3024 mL |
| 5 mM | 0.2904 mL | 1.4521 mL | 2.9042 mL | 7.2605 mL | |
| 10 mM | 0.1452 mL | 0.7260 mL | 1.4521 mL | 3.6302 mL | |
| 15 mM | 0.0968 mL | 0.4840 mL | 0.9681 mL | 2.4202 mL | |
| 20 mM | 0.0726 mL | 0.3630 mL | 0.7260 mL | 1.8151 mL | |
| 25 mM | 0.0581 mL | 0.2904 mL | 0.5808 mL | 1.4521 mL | |
| 30 mM | 0.0484 mL | 0.2420 mL | 0.4840 mL | 1.2101 mL | |
| 40 mM | 0.0363 mL | 0.1815 mL | 0.3630 mL | 0.9076 mL | |
| 50 mM | 0.0290 mL | 0.1452 mL | 0.2904 mL | 0.7260 mL | |
| 60 mM | 0.0242 mL | 0.1210 mL | 0.2420 mL | 0.6050 mL | |
| 80 mM | 0.0182 mL | 0.0908 mL | 0.1815 mL | 0.4538 mL | |
| 100 mM | 0.0145 mL | 0.0726 mL | 0.1452 mL | 0.3630 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
YNT-185 dihydrochloride Related Classifications
HY-136181 Related Classifications
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