1. GPCR/G Protein
    Neuronal Signaling
  2. Orexin Receptor (OX Receptor)
  3. YNT-185 dihydrochloride

YNT-185 dihydrochloride 

Cat. No.: HY-136181
Handling Instructions

YNT-185 dihydrochloride is a nonpeptide, selective orexin type-2 receptor (OX2R) agonist, with EC50s of 0.028 and 2.75 μM for OX2R and OX1R, respectively. YNT-185 dihydrochloride ameliorates narcolepsy-cataplexy symptoms in mouse models.

For research use only. We do not sell to patients.

YNT-185 dihydrochloride Chemical Structure

YNT-185 dihydrochloride Chemical Structure

CAS No. : 1804978-82-2

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Description

YNT-185 dihydrochloride is a nonpeptide, selective orexin type-2 receptor (OX2R) agonist, with EC50s of 0.028 and 2.75 μM for OX2R and OX1R, respectively. YNT-185 dihydrochloride ameliorates narcolepsy-cataplexy symptoms in mouse models[1][2].

IC50 & Target[1]

OX2 Receptor

0.028 μM (EC50)

OX1 Receptor

2.75 μM (EC50)

In Vivo

YNT-185 dihydrochloride (20-40 mg/kg; i.p.) increases wakefulness in mice[2].
YNT-185 (300 nmol; i.c.v.) significantly increases wake time for 3 hours in a dose-dependent manner, accompanied by a decrease in NREM sleep time, in wild-type mice but not in OXRDKO mice[2].

Animal Model: Male wild-type C57BL/6J mice[2]
Dosage: 20, 40 mg/kg
Administration: I.p.
Result: Wake time was also significantly increased.
Molecular Weight

688.66

Formula

C₃₃H₃₉Cl₂N₅O₅S

CAS No.

1804978-82-2

SMILES

O=[S](NC1=CC(NCCNC(C(C=CC=C2)=C2N(C)C)=O)=CC=C1)(C(C=C(C3=CC(C(N(C)C)=O)=CC=C3)C=C4)=C4OC)=O.Cl.Cl

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

YNT-185YNT185YNT 185Orexin Receptor (OX Receptor)Hypocretin ReceptorHCRT Receptornarcolepsy-cataplexysymptomsnonpeptidewakefulnesssleepGprotein-coupledreceptorsInhibitorinhibitorinhibit

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YNT-185 dihydrochloride
Cat. No.:
HY-136181
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