1. GPCR/G Protein
    Neuronal Signaling
  2. Orexin Receptor (OX Receptor)
  3. YNT-185

YNT-185 

Cat. No.: HY-136181A
Handling Instructions

YNT-185 is a nonpeptide, selective orexin type-2 receptor (OX2R) agonist, with EC50s of 0.028 and 2.75 μM for OX2R and OX1R, respectively. YNT-185 ameliorates narcolepsy-cataplexy symptoms in mouse models.

For research use only. We do not sell to patients.

YNT-185 Chemical Structure

YNT-185 Chemical Structure

CAS No. : 1804978-81-1

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Description

YNT-185 is a nonpeptide, selective orexin type-2 receptor (OX2R) agonist, with EC50s of 0.028 and 2.75 μM for OX2R and OX1R, respectively. YNT-185 ameliorates narcolepsy-cataplexy symptoms in mouse models[1][2].

In Vivo

YNT-185 (20-40 mg/kg; i.p.) increases wakefulness in mice[2].
YNT-185 (300 nmol; i.c.v.) significantly increases wake time for 3 hours in a dose-dependent manner, accompanied by a decrease in NREM sleep time, in wild-type mice but not in OXRDKO mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male wild-type C57BL/6J mice[2]
Dosage: 20, 40 mg/kg
Administration: I.p.
Result: Wake time was also significantly increased.
Molecular Weight

615.74

Formula

C₃₃H₃₇N₅O₅S

CAS No.
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YNT-185
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HY-136181A
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