2. Recombinant Proteins
  3. Receptor Proteins
  4. G-Protein-Coupled Receptors (GPCRs)
  5. OX2R Protein, Human (Sf9, FLAG, His)

OX2R Protein, Human (Sf9, FLAG, His)

Cat. No.: HY-P702084
COA Handling Instructions

OX2R Protein, a nonselective, high-affinity receptor, functions as a key binding site for orexin-A and orexin-B neuropeptides. Its interaction with orexin-A leads to a significant increase in cytoplasmic Ca(2+) levels, indicating its involvement in cellular responses associated with neuropeptide activation. OX2R Protein, Human (Sf9, FLAG, His) is a recombinant protein dimer complex containing human-derived OX2R protein, expressed by Sf9 insect cells , with N-Flag, C-10*His labeled tag. OX2R Protein, Human (Sf9, FLAG, His), has molecular weight of 64.6 kDa.

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Description

OX2R Protein, a nonselective, high-affinity receptor, functions as a key binding site for orexin-A and orexin-B neuropeptides. Its interaction with orexin-A leads to a significant increase in cytoplasmic Ca(2+) levels, indicating its involvement in cellular responses associated with neuropeptide activation. OX2R Protein, Human (Sf9, FLAG, His) is a recombinant protein dimer complex containing human-derived OX2R protein, expressed by Sf9 insect cells , with N-Flag, C-10*His labeled tag. OX2R Protein, Human (Sf9, FLAG, His), has molecular weight of 64.6 kDa.
Background

OX2R Protein, a nonselective, high-affinity receptor, serves as a key binding site for both orexin-A and orexin-B neuropeptides. Upon orexin-A binding, OX2R triggers a notable elevation in cytoplasmic Ca(2+) levels, implicating its role in orchestrating cellular responses associated with the activation of these neuropeptides.
Species

Human
Source

Sf9 insect cells
Tag

N-Flag;C-10*His
Accession

O43614 (M1-Q254&K294-H388)
Gene ID

3062
Synonyms
HCRTR2; Orexin receptor type 2; Ox-2-R; Ox2-R; Ox2R; Hypocretin receptor type 2
Molecular Weight

64.6 KDa
Purity

Greater than 90% as determined by reducing SDS-PAGE.
Endotoxin Level

/
Documentation

COA (220 KB)

Handling Instructions (2659 KB)

OX2R Protein, Human (Sf9, FLAG, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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