TCS-OX2-29 hydrochloride
Based on 3 publication(s) in Google Scholar
TCS-OX2-29 (hydrochloride) is a potent, high affinities and selective orexin-2 receptor (OX2R) antagonist with an IC50 value of 40 nM and a pKI value of 7.5. TCS-OX2-29 displays ~250-fold selectivity for OX2 over OX1.
For research use only. We do not sell to patients.
- CAS No.: 1610882-30-8
- Formula: C23H32ClN3O3
- Molecular Weight:433.97
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) TCS-OX2-29 hydrochloride
MoreAll Orexin Receptor (OX Receptor) Isoforms
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Biological Activity
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OX2 Receptor |
Chemical Information
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CAS No. 1610882-30-8
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Molecular Weight 433.97
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Formula C23H32ClN3O3
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SMILES
CC(C)(C)[C@H](NCC1=CC=NC=C1)C(N2CC3=C(C=C(OC)C(OC)=C3)CC2)=O.[H]Cl
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Synonyms
OX2R antagonist
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (3)
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Journal Impact Factor
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Most Recent
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J Pineal Res
Melatonin protects embryonic development and maintains sleep/wake behaviors from the deleterious effects of fluorene-9-bisphenol in zebrafish (Danio rerio). [Abstract]2019 Jan;66(1):e12530. PMID: 30269372 -
Med Sci Monit
2019 Apr 19:25:2886-2895. PMID: 31002658 -
bioRxiv
Prioritizing Neuroactive Ligands Using Motif-Guided Virtual Discovery and Zebrafish Profiling. [Abstract]2026 Jan 16:2026.01.15.699747. PMID: 41648545
Purity & Documentation
References
[1]. Hirose M, et al. N-acyl 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline: the first orexin-2 receptor selective non-peptidic antagonist. Bioorg Med Chem Lett. 2003 Dec 15;13(24):4497-9. [Content Brief]
[2]. Tabaeizadeh M, et al. The differential effects of OX1R and OX2R selective antagonists on morphine conditioned place preference in naïve versus morphine-dependent mice. Behav Brain Res. 2013 Jan 15;237:41-8. [Content Brief]
[3]. Mould R, et al. Binding kinetics differentiates functional antagonism of orexin-2 receptor ligands. Br J Pharmacol. 2014 Jan;171(2):351-63. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TCS-OX2-29 hydrochloride Related Classifications
HY-100452A Related Classifications
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