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Cat. No.: HY-184054

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Balumorexton

Balumorexton is an orally active orexin type 2 receptor (OX2R) agonist. Balumorexton is used for the research of narcolepsy.

For research use only. We do not sell to patients.

CAS No.: 3037907-48-2
Formula: C₂₀H₁₂F₆N₄O₄S
Molecular Weight:518.39

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Balumorexton Chemical Structure

CAS No.: 3037907-48-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

Balumorexton is an orally active orexin type 2 receptor (OX2R) agonist. Balumorexton is used for the research of narcolepsy^[1].

IC₅₀ & Target

^[1]

OX2R

All Orexin Receptor (OX Receptor) Isoforms :

In Vitro

Balumorexton (Example 77) (3 μM; calcium flux endpoint assay) exhibits OX2R agonistic activity in CHO-K1 cells stably expressing human OX2R, with a relative activation rate of 100%^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Balumorexton (Example 77) (1 mg/kg; p.o.; single administration) increases the wakefulness duration of cynomolgus monkeys, which reaches 645.09% of that in the vehicle control group^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3037907-48-2
Molecular Weight 518.39
Formula C₂₀H₁₂F₆N₄O₄S
SMILES

FC1=CC=C2ON=C(N3C=C4N(C[C@H](C4(F)F)NS(C)(=O)=O)C3=O)C2=C1C5=C(C=C(C=C5F)F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Hattori Y, et al. Heterocyclic compound. WO2024095133A1. WIPO; 2024 May 10.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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