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HAUS1 - HAUS augmin like complex subunit 1 Gene

Also Known as HEIC; CCDC5; HEI-C; HsT1461

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 115106

About HAUS1

Cytogenetic location: 18q21.1 Genomic coordinates (GRCh38): 18:46,104,385-46,128,333 (from NCBI)

This gene has 12 transcripts (splice variants) and 203 orthologues. Ubiquitous expression in lymph node (RPKM 14.6), bone marrow (RPKM 12.1) and 25 other tissues.

Summary

HAUS1 is 1 of 8 subunits of the 390-kD human augmin complex, or HAUS complex. The augmin complex was first identified in Drosophila, and its name comes from the Latin verb 'augmentare,' meaning 'to increase.' The augmin complex is a microtubule-binding complex involved in microtubule generation within the mitotic spindle and is vital to mitotic spindle assembly (Goshima et al., 2008 [PubMed 18443220]; Uehara et al., 2009 [PubMed 19369198]).[supplied by OMIM, Jun 2010]

HAUS1 Products (1)

mRNA	Protein	Name
NM_138443.4	NP_612452.1	HAUS augmin-like complex subunit 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19369198	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in centrosome cycle	IMP IMP: Inferred from mutant phenotype	19427217	GOA
involved in spindle assembly	IMP IMP: Inferred from mutant phenotype	19369198	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of HAUS complex	IDA IDA: Inferred from direct assay	19369198	GOA
part of HAUS complex	IPI IPI: Inferred from physical interaction	20360068	GOA
located in centrosome	IDA IDA: Inferred from direct assay	21399614	GOA
located in mitotic spindle microtubule	IDA IDA: Inferred from direct assay	30723163	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
HAUS augmin-like complex subunit 1	coiled-coil domain containing 5 (spindle associated)

HAUS1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	HAUS1	Q96CS2	KRT40	Homo sapiens	Q6A162	Y2H Prey Pooling	25416956
Intra	HAUS1	Q96CS2	KRT40	Homo sapiens	Q6A162	Validated Y2H	25416956
Intra	HAUS1	Q96CS2	NECAB2	Homo sapiens	Q7Z6G3-2	Validated Y2H	25416956
Intra	HAUS1	Q96CS2	ODAD1	Homo sapiens	Q96M63	Y2H Prey Pooling	25416956
Intra	HAUS1	Q96CS2	ODAD1	Homo sapiens	Q96M63	Validated Y2H	25416956
Intra	HAUS1	Q96CS2	CCHCR1	Homo sapiens	Q8TD31-3	Y2H Prey Pooling	25416956
Intra	HAUS1	Q96CS2	CCHCR1	Homo sapiens	Q8TD31-3	Validated Y2H	25416956
Intra	HAUS1	Q96CS2	CCHCR1	Homo sapiens	Q8TD31-3	Y2H Array	25416956
Intra	HAUS1	Q96CS2	TFPT	Homo sapiens	P0C1Z6-2	Y2H Array	25416956
Intra	HAUS1	Q96CS2	TFPT	Homo sapiens	P0C1Z6-2	Validated Y2H	25416956
Intra	HAUS1	Q96CS2	CEP57L1	Homo sapiens	Q8IYX8-2	Validated Y2H	25416956
Intra	HAUS1	Q96CS2	CEP57L1	Homo sapiens	Q8IYX8-2	Y2H Array	25416956
Intra	HAUS1	Q96CS2	BORCS6	Homo sapiens	Q96GS4	Validated Y2H	32296183
Intra	HAUS1	Q96CS2	CAGE1	Homo sapiens	Q8TC20	Validated Y2H	25416956
Intra	HAUS1	Q96CS2	CENPP	Homo sapiens	Q6IPU0	Y2H Prey Pooling	32296183
Intra	HAUS1	Q96CS2	SYCE3	Homo sapiens	A1L190	Y2H Array	31515488
Intra	HAUS1	Q96CS2	CRSP9	Homo sapiens	Q6IAZ5	Y2H Prey Pooling	25416956
Intra	HAUS1	Q96CS2	CRSP9	Homo sapiens	Q6IAZ5	Validated Y2H	25416956
Intra	HAUS1	Q96CS2	MAGEA6	Homo sapiens	P43360	Validated Y2H	25416956
Intra	HAUS1	Q96CS2	KRT38	Homo sapiens	O76015	Y2H Array	29892012
Intra	HAUS1	Q96CS2	KRT38	Homo sapiens	O76015	Validated Y2H	25416956
Intra	HAUS1	Q96CS2	KRT38	Homo sapiens	O76015	Y2H Array	25416956
Intra	HAUS1	Q96CS2	KRT38	Homo sapiens	O76015	Y2H Prey Pooling	25416956
Intra	HAUS1	Q96CS2	FGFR1OP2	Homo sapiens	Q9NVK5	Y2H Array	25416956
Intra	HAUS1	Q96CS2	FGFR1OP2	Homo sapiens	Q9NVK5	Y2H Prey Pooling	25416956
Intra	HAUS1	Q96CS2	FGFR1OP2	Homo sapiens	Q9NVK5	Validated Y2H	25416956
Intra	HAUS1	Q96CS2	PDE4DIP	Homo sapiens	Q5VU43	Validated Y2H	25416956
Intra	HAUS1	Q96CS2	TFIP11	Homo sapiens	Q9UBB9	Y2H Array	25416956
Intra	HAUS1	Q96CS2	TRIM69	Homo sapiens	Q86WT6-2	MAPPIT	32296183
Intra	HAUS1	Q96CS2	CDR2	Homo sapiens	Q01850	Y2H Prey Pooling	25416956
Intra	HAUS1	Q96CS2	CDR2	Homo sapiens	Q01850	Validated Y2H	25416956
Intra	HAUS1	Q96CS2	CDR2	Homo sapiens	Q01850	Y2H Array	25416956
Intra	HAUS1	Q96CS2	KIFC3	Homo sapiens	Q9BVG8	Validated Y2H	25416956
Intra	HAUS1	Q96CS2	MIPOL1	Homo sapiens	Q8TD10	Y2H Array	25416956
Intra	HAUS1	Q96CS2	HAUS4	Homo sapiens	Q9H6D7	GMS	25173975
Intra	HAUS1	Q96CS2	HAUS4	Homo sapiens	Q9H6D7	SLC	27107012
Intra	HAUS1	Q96CS2	HAUS4	Homo sapiens	Q9H6D7	DLS	25173975
Intra	HAUS1	Q96CS2	HAUS4	Homo sapiens	Q9H6D7	TEM	25173975
Intra	HAUS1	Q96CS2	HAUS4	Homo sapiens	Q9H6D7	SLS	25173975
Intra	HAUS1	Q96CS2	HAUS4	Homo sapiens	Q9H6D7	GMS	19369198
Intra	HAUS1	Q96CS2	HAUS6	Homo sapiens	Q7Z4H7	GMS	25173975
Intra	HAUS1	Q96CS2	HAUS6	Homo sapiens	Q7Z4H7	TAP	20360068
Intra	HAUS1	Q96CS2	HAUS6	Homo sapiens	Q7Z4H7	TEM	25173975
Intra	HAUS1	Q96CS2	HAUS6	Homo sapiens	Q7Z4H7	DLS	25173975
Intra	HAUS1	Q96CS2	HAUS6	Homo sapiens	Q7Z4H7	GMS	19369198
Intra	HAUS1	Q96CS2	HAUS6	Homo sapiens	Q7Z4H7	SLS	25173975
Intra	HAUS1	Q96CS2	ATP6V1D	Homo sapiens	Q9Y5K8	Validated Y2H	32296183
Intra	HAUS1	Q96CS2	VPS52	Homo sapiens	Q8N1B4	Validated Y2H	25416956
Intra	HAUS1	Q96CS2	VPS52	Homo sapiens	Q8N1B4	Y2H Array	25416956
Intra	HAUS1	Q96CS2	CCDC57	Homo sapiens	Q2TAC2	Y2H Prey Pooling	25416956
Intra	HAUS1	Q96CS2	C3orf62	Homo sapiens	Q6ZUJ4	Y2H Array	31515488
Intra	HAUS1	Q96CS2	C3orf62	Homo sapiens	Q6ZUJ4	Y2H Prey Pooling	25416956
Intra	HAUS1	Q96CS2	TXN2	Homo sapiens	Q99757	Validated Y2H	32296183
Intra	HAUS1	Q96CS2	TXN2	Homo sapiens	Q99757	Y2H Array	32296183
Intra	HAUS1	Q96CS2	DMD	Homo sapiens	P11532	Y2H Array	25416956
Intra	HAUS1	Q96CS2	KRT18	Homo sapiens	P05783	Y2H Prey Pooling	25416956
Intra	HAUS1	Q96CS2	KRT18	Homo sapiens	P05783	Y2H Array	25416956
Intra	HAUS1	Q96CS2	TSG101	Homo sapiens	Q99816	Y2H Prey Pooling	25416956
Intra	HAUS1	Q96CS2	TSG101	Homo sapiens	Q99816	Validated Y2H	32296183
Intra	HAUS1	Q96CS2	TSG101	Homo sapiens	Q99816	Y2H Array	25416956
Intra	HAUS1	Q96CS2	NUP62	Homo sapiens	P37198	Y2H Array	25416956
Intra	HAUS1	Q96CS2	NUP62	Homo sapiens	P37198	Validated Y2H	25416956
Intra	HAUS1	Q96CS2	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	HAUS1	Q96CS2	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	HAUS1	Q96CS2	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	HAUS1	Q96CS2	HRAS	Homo sapiens	P01112	Validated Y2H	32814053
Intra	HAUS1	Q96CS2	HRAS	Homo sapiens	P01112	Y2H Pooling	32814053
Intra	HAUS1	Q96CS2	HRAS	Homo sapiens	P01112	Y2H Array	32814053
Intra	HAUS1	Q96CS2	GSN	Homo sapiens	P06396	Validated Y2H	32814053
Intra	HAUS1	Q96CS2	GSN	Homo sapiens	P06396	Y2H Pooling	32814053
Intra	HAUS1	Q96CS2	GSN	Homo sapiens	P06396	Y2H Array	32814053
Intra	HAUS1	Q96CS2	TRAF1	Homo sapiens	Q13077	Y2H Prey Pooling	25416956
Intra	HAUS1	Q96CS2	MED4	Homo sapiens	Q9NPJ6	Y2H Prey Pooling	25416956
Intra	HAUS1	Q96CS2	SPAG5	Homo sapiens	Q96R06	Y2H Prey Pooling	25416956
Intra	HAUS1	Q96CS2	SPAG5	Homo sapiens	Q96R06	Validated Y2H	25416956
Intra	HAUS1	Q96CS2	BLOC1S6	Homo sapiens	Q9UL45	Y2H Prey Pooling	25416956
Intra	HAUS1	Q96CS2	DTNBP1	Homo sapiens	Q96EV8	Validated Y2H	25416956
Intra	HAUS1	Q96CS2	DTNBP1	Homo sapiens	Q96EV8	Y2H Array	25416956
Intra	HAUS1	Q96CS2	POLR3C	Homo sapiens	Q9BUI4	Validated Y2H	32296183
Intra	HAUS1	Q96CS2	GOLGA2	Homo sapiens	Q08379	Y2H Array	25416956
Intra	HAUS1	Q96CS2	ARFIP2	Homo sapiens	P53365	Validated Y2H	25416956
Intra	HAUS1	Q96CS2	INCA1	Homo sapiens	Q0VD86	Y2H Array	25416956
Intra	HAUS1	Q96CS2	INCA1	Homo sapiens	Q0VD86	Validated Y2H	25416956
Intra	HAUS1	Q96CS2	SYCE1	Homo sapiens	Q8N0S2	Y2H Array	25416956
Intra	HAUS1	Q96CS2	SYCE1	Homo sapiens	Q8N0S2	Y2H Prey Pooling	25416956
Intra	HAUS1	Q96CS2	KDM1A	Homo sapiens	O60341	Anti Tag CoIP	23455924
Intra	HAUS1	Q96CS2	WASHC3	Homo sapiens	Q9Y3C0	Y2H Prey Pooling	25416956
Intra	HAUS1	Q96CS2	WASHC3	Homo sapiens	Q9Y3C0	Validated Y2H	25416956
Intra	HAUS1	Q96CS2	WASHC3	Homo sapiens	Q9Y3C0	Validated Y2H	32296183
Intra	HAUS1	Q96CS2	WASHC3	Homo sapiens	Q9Y3C0	Y2H Array	25416956
Intra	HAUS1	Q96CS2	STX11	Homo sapiens	O75558	Y2H Prey Pooling	25416956
Intra	HAUS1	Q96CS2	DCTN2	Homo sapiens	Q13561	Y2H Prey Pooling	25416956
Intra	HAUS1	Q96CS2	DCTN2	Homo sapiens	Q13561	Validated Y2H	25416956
Intra	HAUS1	Q96CS2	DCTN2	Homo sapiens	Q13561	Y2H Array	25416956
Intra	HAUS1	Q96CS2	NDC80	Homo sapiens	O14777	Validated Y2H	25416956
Intra	HAUS1	Q96CS2	NINL	Homo sapiens	Q9Y2I6	Y2H Array	25416956
Intra	HAUS1	Q96CS2	NINL	Homo sapiens	Q9Y2I6	Validated Y2H	25416956
Intra	HAUS1	Q96CS2	FAM161B	Homo sapiens	Q96MY7	Validated Y2H	32296183
Intra	HAUS1	Q96CS2	KRT15	Homo sapiens	P19012	Y2H Array	25416956
Intra	HAUS1	Q96CS2	KRT15	Homo sapiens	P19012	Y2H Prey Pooling	25416956
Intra	HAUS1	Q96CS2	USHBP1	Homo sapiens	Q8N6Y0	Validated Y2H	25416956
Intra	HAUS1	Q96CS2	TRIM23	Homo sapiens	P36406	Validated Y2H	25416956
Intra	HAUS1	Q96CS2	LDOC1	Homo sapiens	O95751	Validated Y2H	25416956
Intra	HAUS1	Q96CS2	LDOC1	Homo sapiens	O95751	Y2H Array	25416956
Intra	HAUS1	Q96CS2	NUP54	Homo sapiens	Q7Z3B4	Y2H Array	25416956
Intra	HAUS1	Q96CS2	NUP54	Homo sapiens	Q7Z3B4	Validated Y2H	25416956
Intra	HAUS1	Q96CS2	NUP54	Homo sapiens	Q7Z3B4	Y2H Prey Pooling	25416956
Intra	HAUS1	Q96CS2	LURAP1	Homo sapiens	Q96LR2	Y2H Array	31515488
Intra	HAUS1	Q96CS2	LURAP1	Homo sapiens	Q96LR2	Y2H Prey Pooling	25416956
Intra	HAUS1	Q96CS2	CBY2	Homo sapiens	Q8NA61	Y2H Prey Pooling	25416956
Intra	HAUS1	Q96CS2	CBY2	Homo sapiens	Q8NA61	Y2H Array	25416956
Intra	HAUS1	Q96CS2	CEP63	Homo sapiens	Q96MT8	Validated Y2H	25416956
Intra	HAUS1	Q96CS2	MAD1L1	Homo sapiens	Q9Y6D9	Validated Y2H	25416956
Intra	HAUS1	Q96CS2	KRT19	Homo sapiens	P08727	Y2H Prey Pooling	25416956
Intra	HAUS1	Q96CS2	CEP170P1	Homo sapiens	Q96L14	Y2H Prey Pooling	25416956
Intra	HAUS1	Q96CS2	CEP44	Homo sapiens	Q9C0F1	Y2H Array	25416956
Intra	HAUS1	Q96CS2	CEP44	Homo sapiens	Q9C0F1	Y2H Prey Pooling	25416956
Intra	HAUS1	Q96CS2	IFT20	Homo sapiens	Q8IY31	Y2H Prey Pooling	25416956
Intra	HAUS1	Q96CS2	IFT20	Homo sapiens	Q8IY31	Validated Y2H	25416956
Intra	HAUS1	Q96CS2	IFIT3	Homo sapiens	O14879	Y2H Prey Pooling	25416956
Intra	HAUS1	Q96CS2	IFIT3	Homo sapiens	O14879	Y2H Array	25416956
Intra	HAUS1	Q96CS2	CEP55	Homo sapiens	Q53EZ4	Y2H Prey Pooling	25416956
Intra	HAUS1	Q96CS2	CEP55	Homo sapiens	Q53EZ4	Y2H Array	25416956
Intra	HAUS1	Q96CS2	TRIM69	Homo sapiens	Q86WT6	Y2H Array	25416956
Intra	HAUS1	Q96CS2	TRIM69	Homo sapiens	Q86WT6	Validated Y2H	25416956
Intra	HAUS1	Q96CS2	AK8	Homo sapiens	Q96MA6	Validated Y2H	25416956
Intra	HAUS1	Q96CS2	AK8	Homo sapiens	Q96MA6	Y2H Prey Pooling	25416956
Intra	HAUS1	Q96CS2	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Aleukemic Leukemia Cutis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06013	HAUS1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	HAUS1	MGD	MGI:2385076
Rattus norvegicus	HAUS1	RGD	RGD:619909
Canis familiaris	HAUS1	VGNC	VGNC:41602
Bos taurus	HAUS1	VGNC	VGNC:29757
Felis catus	HAUS1	VGNC	VGNC:62755
Macaca mulatta	HAUS1	VGNC	VGNC:103824
Others	HAUS1	NCBI