NUP62 - nucleoporin 62 Gene

Also Known as p62; IBSN; SNDI

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23636

About NUP62

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:49,906,825-49,929,504 (from NCBI)

This gene has 28 transcripts (splice variants), 169 orthologues, 1 paralogue and is associated with 3 phenotypes. Ubiquitous expression in testis (RPKM 21.4), appendix (RPKM 16.1) and 25 other tissues.

Summary

The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a member of the FG-repeat containing nucleoporins and is localized to the nuclear pore central plug. This protein associates with the importin alpha/beta complex which is involved in the import of proteins containing nuclear localization signals. Multiple transcript variants of this gene encode a single protein isoform. [provided by RefSeq, Jul 2008]

NUP62 Products (5)

mRNA	Protein	Name
NM_001193357.2	NP_001180286.1	nuclear pore glycoprotein p62
NM_012346.5	NP_036478.2	nuclear pore glycoprotein p62
NM_016553.5	NP_057637.2	nuclear pore glycoprotein p62
NM_153718.4	NP_714940.1	nuclear pore glycoprotein p62
NM_153719.4	NP_714941.1	nuclear pore glycoprotein p62

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	7744965	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cell surface receptor signaling pathway	IDA IDA: Inferred from direct assay	10799545	GOA
involved in centriole assembly	IMP IMP: Inferred from mutant phenotype	24107630	GOA
involved in centrosome cycle	IMP IMP: Inferred from mutant phenotype	24107630	GOA
involved in mitotic centrosome separation	IMP IMP: Inferred from mutant phenotype	24107630	GOA
involved in mitotic metaphase chromosome alignment	IMP IMP: Inferred from mutant phenotype	24107630	GOA
involved in negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	11013214	GOA
involved in positive regulation of centriole replication	IMP IMP: Inferred from mutant phenotype	24107630	GOA
involved in positive regulation of mitotic cytokinetic process	IMP IMP: Inferred from mutant phenotype	24107630	GOA
involved in positive regulation of mitotic nuclear division	IMP IMP: Inferred from mutant phenotype	24107630	GOA
involved in positive regulation of protein localization to centrosome	IMP IMP: Inferred from mutant phenotype	24107630	GOA
involved in regulation of mitotic spindle organization	IMP IMP: Inferred from mutant phenotype	24107630	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in Flemming body	IDA IDA: Inferred from direct assay	19166812	GOA
located in centrosome	IDA IDA: Inferred from direct assay	24107630	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	24107630	GOA
located in mitotic spindle	IDA IDA: Inferred from direct assay	24107630	GOA
located in nuclear envelope	IDA IDA: Inferred from direct assay	17098863	GOA
part of nuclear pore	IDA IDA: Inferred from direct assay	1915414	GOA
part of ribonucleoprotein complex	IDA IDA: Inferred from direct assay	18809582	GOA
located in spindle pole	IDA IDA: Inferred from direct assay	24107630	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NUP62 Protein Structure

Nsp1_C

0
100
200
300
400
522 a.a.

Protein Preferred Names	Protein Names
nuclear pore glycoprotein p62	62 kDa nucleoporin

NUP62 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	NUP62	P37198	SSC5D	Homo sapiens	A1L4H1	Y2H Prey Pooling	25416956
Intra	NUP62	P37198	SSC5D	Homo sapiens	A1L4H1	Y2H Array	25416956
Intra	NUP62	P37198	CCHCR1	Homo sapiens	Q8TD31-3	Validated Y2H	32296183
Intra	NUP62	P37198	CCHCR1	Homo sapiens	Q8TD31-3	Y2H Array	25416956
Intra	NUP62	P37198	CEP57L1	Homo sapiens	Q8IYX8-2	Validated Y2H	25416956
Intra	NUP62	P37198	HSF2	Homo sapiens	Q03933-2	Y2H Array	25416956
Intra	NUP62	P37198	HSF2	Homo sapiens	Q03933-2	Y2H Prey Pooling	25416956
Intra	NUP62	P37198	BFSP1	Homo sapiens	Q12934	Validated Y2H	25416956
Intra	NUP62	P37198	XPO6	Homo sapiens	Q96QU8	Y2H Array	29892012
Intra	NUP62	P37198	DRC12	Homo sapiens	Q494R4	Y2H Array	25416956
Intra	NUP62	P37198	DRC12	Homo sapiens	Q494R4	Validated Y2H	25416956
Intra	NUP62	P37198	DRC12	Homo sapiens	Q494R4	Y2H Prey Pooling	25416956
Intra	NUP62	P37198	KLHL32	Homo sapiens	Q5THT1	Y2H Prey Pooling	25416956
Intra	NUP62	P37198	KLHL32	Homo sapiens	Q5THT1	Validated Y2H	25416956
Intra	NUP62	P37198	CCDC146	Homo sapiens	Q8IYE0-2	Y2H Array	25416956
Intra	NUP62	P37198	q9h614_human	Homo sapiens	Q9H614	Y2H Array	25416956
Intra	NUP62	P37198	ISCU	Homo sapiens	Q9H1K1	Validated Y2H	32296183
Intra	NUP62	P37198	ISCU	Homo sapiens	Q9H1K1	Y2H Array	25416956
Intra	NUP62	P37198	CCDC146	Homo sapiens	Q8IYE0	Validated Y2H	32296183
Intra	NUP62	P37198	TRIML2	Homo sapiens	Q8N7C3	Validated Y2H	32296183
Intra	NUP62	P37198	OTUD6A	Homo sapiens	Q7L8S5	Validated Y2H	32296183
Intra	NUP62	P37198	HSF4	Homo sapiens	Q9ULV5-2	Validated Y2H	32296183
Intra	NUP62	P37198	DPPA3	Homo sapiens	Q6W0C5	Validated Y2H	32296183
Intra	NUP62	P37198	TLE4	Homo sapiens	Q04727-2	Validated Y2H	32296183
Intra	NUP62	P37198	BFSP1	Homo sapiens	Q12934-2	Validated Y2H	32296183
Intra	NUP62	P37198	KIFC3	Homo sapiens	Q9BVG8	Y2H Prey Pooling	25416956
Intra	NUP62	P37198	KIFC3	Homo sapiens	Q9BVG8	Y2H Array	25416956
Intra	NUP62	P37198	HAUS1	Homo sapiens	Q96CS2	Y2H Prey Pooling	25416956
Intra	NUP62	P37198	CENPU	Homo sapiens	Q71F23	Anti Tag CoIP	33961781
Intra	NUP62	P37198	CENPU	Homo sapiens	Q71F23	Validated Y2H	25416956
Intra	NUP62	P37198	HSF2	Homo sapiens	Q03933	Y2H Array	31515488
Intra	NUP62	P37198	HSF2	Homo sapiens	Q03933	Y2H Array	25416956
Intra	NUP62	P37198	HSF2	Homo sapiens	Q03933	Validated Y2H	25416956
Intra	NUP62	P37198	IKBIP	Homo sapiens	Q70UQ0	Y2H Array	25416956
Intra	NUP62	P37198	NUP58	Homo sapiens	Q9BVL2	Anti Tag CoIP	33961781
Intra	NUP62	P37198	NUP58	Homo sapiens	Q9BVL2	Y2H Array	31515488
Intra	NUP62	P37198	NUP58	Homo sapiens	Q9BVL2	Y2H Prey Pooling	25416956
Intra	NUP62	P37198	NUP58	Homo sapiens	Q9BVL2	Y2H Array	25416956
Intra	NUP62	P37198	CCDC121	Homo sapiens	Q6ZUS5	Validated Y2H	25416956
Intra	NUP62	P37198	CCDC121	Homo sapiens	Q6ZUS5	Y2H Array	25416956
Intra	NUP62	P37198	CCDC121	Homo sapiens	Q6ZUS5	Y2H Prey Pooling	25416956
Intra	NUP62	P37198	KPNA2	Homo sapiens	P52292	Y2H Prey Pooling	25416956
Intra	NUP62	P37198	TXLNA	Homo sapiens	P40222	Validated Y2H	32296183
Intra	NUP62	P37198	CAVIN3	Homo sapiens	Q969G5	Validated Y2H	32296183
Intra	NUP62	P37198	SUOX	Homo sapiens	P51687	Validated Y2H	32296183
Intra	NUP62	P37198	AGR3	Homo sapiens	Q8TD06	Validated Y2H	25416956
Intra	NUP62	P37198	AGR3	Homo sapiens	Q8TD06	Y2H Prey Pooling	25416956
Intra	NUP62	P37198	AGR3	Homo sapiens	Q8TD06	Validated Y2H	32296183
Intra	NUP62	P37198	NXF1	Homo sapiens	Q9UBU9	Y2H Prey Pooling	25416956
Intra	NUP62	P37198	NXF1	Homo sapiens	Q9UBU9	Y2H Prey Pooling	32296183
Intra	NUP62	P37198	NXF1	Homo sapiens	Q9UBU9	Anti Bait CoIP	23477864
Intra	NUP62	P37198	NXF1	Homo sapiens	Q9UBU9	Validated Y2H	32296183
Intra	NUP62	P37198	NXF1	Homo sapiens	Q9UBU9	Pull Down	10668806
Intra	NUP62	P37198	PELI2	Homo sapiens	Q9HAT8	Validated Y2H	32296183
Intra	NUP62	P37198	SMARCE1	Homo sapiens	Q969G3	Y2H Prey Pooling	25416956
Intra	NUP62	P37198	SMARCE1	Homo sapiens	Q969G3	Validated Y2H	25416956
Intra	NUP62	P37198	SMARCE1	Homo sapiens	Q969G3	Y2H Array	25416956
Intra	NUP62	P37198	BLOC1S6	Homo sapiens	Q9UL45	Validated Y2H	32296183
Intra	NUP62	P37198	BLOC1S6	Homo sapiens	Q9UL45	Validated Y2H	25416956
Intra	NUP62	P37198	BLOC1S6	Homo sapiens	Q9UL45	Y2H Prey Pooling	25416956
Intra	NUP62	P37198	BLOC1S6	Homo sapiens	Q9UL45	Y2H Array	25416956
Intra	NUP62	P37198	OIP5	Homo sapiens	O43482	Validated Y2H	25416956
Intra	NUP62	P37198	NUTF2	Homo sapiens	P61970	Validated Y2H	32296183
Intra	NUP62	P37198	NUTF2	Homo sapiens	P61970	Y2H Prey Pooling	25416956
Intra	NUP62	P37198	ARFIP2	Homo sapiens	P53365	Validated Y2H	32296183
Intra	NUP62	P37198	FABP3	Homo sapiens	P05413	Y2H	21516116
Intra	NUP62	P37198	WASHC3	Homo sapiens	Q9Y3C0	Y2H Prey Pooling	25416956
Intra	NUP62	P37198	WASHC3	Homo sapiens	Q9Y3C0	Validated Y2H	25416956
Intra	NUP62	P37198	WASHC3	Homo sapiens	Q9Y3C0	Y2H Pooling	16189514
Intra	NUP62	P37198	WASHC3	Homo sapiens	Q9Y3C0	Validated Y2H	32296183
Intra	NUP62	P37198	CRCT1	Homo sapiens	Q9UGL9	Validated Y2H	32296183
Intra	NUP62	P37198	CRCT1	Homo sapiens	Q9UGL9	Y2H Array	25416956
Intra	NUP62	P37198	CRCT1	Homo sapiens	Q9UGL9	Y2H Prey Pooling	25416956
Intra	NUP62	P37198	PIN1	Homo sapiens	Q13526	Validated Y2H	32296183
Intra	NUP62	P37198	PIN1	Homo sapiens	Q13526	Y2H Array	25416956
Intra	NUP62	P37198	C14orf119	Homo sapiens	Q9NWQ9	Validated Y2H	32296183
Intra	NUP62	P37198	NUP88	Homo sapiens	Q99567	Anti Tag CoIP	33961781
Intra	NUP62	P37198	NUP88	Homo sapiens	Q99567	Validated Y2H	32296183
Intra	NUP62	P37198	LMO2	Homo sapiens	P25791	Y2H Prey Pooling	25416956
Intra	NUP62	P37198	LMO2	Homo sapiens	P25791	Y2H Array	25416956
Intra	NUP62	P37198	LMO2	Homo sapiens	P25791	Validated Y2H	25416956
Intra	NUP62	P37198	LNX1	Homo sapiens	Q8TBB1	Validated Y2H	32296183
Intra	NUP62	P37198	USHBP1	Homo sapiens	Q8N6Y0	Validated Y2H	32296183
Intra	NUP62	P37198	KANSL1	Homo sapiens	Q7Z3B3	Y2H Prey Pooling	25416956
Intra	NUP62	P37198	KANSL1	Homo sapiens	Q7Z3B3	Validated Y2H	25416956
Intra	NUP62	P37198	DTNB	Homo sapiens	O60941	Validated Y2H	25416956
Intra	NUP62	P37198	DTNB	Homo sapiens	O60941	Y2H Array	25416956
Intra	NUP62	P37198	NUP54	Homo sapiens	Q7Z3B4	Y2H	21516116
Intra	NUP62	P37198	NUP54	Homo sapiens	Q7Z3B4	Y2H Pooling	16189514
Intra	NUP62	P37198	NUP54	Homo sapiens	Q7Z3B4	Y2H Array	31515488
Intra	NUP62	P37198	NUP54	Homo sapiens	Q7Z3B4	Validated Y2H	32296183
Intra	NUP62	P37198	NUP54	Homo sapiens	Q7Z3B4	Anti Tag CoIP	33961781
Intra	NUP62	P37198	NUP54	Homo sapiens	Q7Z3B4	Y2H Prey Pooling	25416956
Intra	NUP62	P37198	THAP1	Homo sapiens	Q9NVV9	Y2H	21516116
Intra	NUP62	P37198	THAP1	Homo sapiens	Q9NVV9	Y2H Pooling	16189514
Intra	NUP62	P37198	THAP1	Homo sapiens	Q9NVV9	Validated Y2H	32296183
Intra	NUP62	P37198	MXD3	Homo sapiens	Q9BW11	Validated Y2H	32296183
Intra	NUP62	P37198	KRT20	Homo sapiens	P35900	Y2H Prey Pooling	25416956
Intra	NUP62	P37198	KRT20	Homo sapiens	P35900	Y2H Array	25416956
Intra	NUP62	P37198	ABI2	Homo sapiens	Q9NYB9	Y2H Array	29892012
Intra	NUP62	P37198	IFT20	Homo sapiens	Q8IY31	Y2H Prey Pooling	25416956
Intra	NUP62	P37198	PHF21A	Homo sapiens	Q96BD5	Y2H Array	31515488
Intra	NUP62	P37198	PHF21A	Homo sapiens	Q96BD5	Validated Y2H	25416956
Intra	NUP62	P37198	PHF21A	Homo sapiens	Q96BD5	Validated Y2H	32296183
Intra	NUP62	P37198	PHF21A	Homo sapiens	Q96BD5	Y2H Prey Pooling	25416956
Intra	NUP62	P37198	PHF21A	Homo sapiens	Q96BD5	Anti Tag CoIP	33961781
Intra	NUP62	P37198	C1orf216	Homo sapiens	Q8TAB5	Y2H Prey Pooling	25416956
Intra	NUP62	P37198	C1orf216	Homo sapiens	Q8TAB5	Validated Y2H	32296183
Intra	NUP62	P37198	SNAPC5	Homo sapiens	O75971	Validated Y2H	25416956
Intra	NUP62	P37198	SNAPC5	Homo sapiens	O75971	Y2H Array	25416956
Intra	NUP62	P37198	ADAM15	Homo sapiens	Q13444	Validated Y2H	25416956
Intra	NUP62	P37198	ADAM15	Homo sapiens	Q13444	Y2H Prey Pooling	25416956
Intra	NUP62	P37198	CCHCR1	Homo sapiens	Q8TD31	Y2H Array	29892012
Intra	NUP62	P37198	CCHCR1	Homo sapiens	Q8TD31	Anti Tag CoIP	33961781
Cross	NUP62	P37198	icp27_hhv11	Human herpesvirus 1	P10238	Anti Bait CoIP	22334672

Cross: Cross-species interaction Intra: Intraspecies interaction

NUP62 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83252	Nucleoporin p62 Antibody (YA2997)	WB	Human

Related Diseases

Diseases	Alias
Striatonigral Degeneration, Infantile	Infantile Bilateral Striatal Necrosis Ibsn SNDI Striatonigral Degeneration Infantile Infantile Striatonigral Degeneration Bilateral Striatal Necrosis, Infantile Striatal Degeneration, Familial Striatal Degeneration Familial Infantile Striatonigral Necrosis Familial Striatal Degeneration
Familial Infantile Bilateral Striatal Necrosis	Familial Ibsn Familial Infantile Striatonigral Degeneration Familial Infantile Striatonigral Necrosis
Striatonigral Degeneration
Mitochondrial Complex I Deficiency, Nuclear Type 16	MC1DN16 Nuclear Type Mitochondrial Complex I Deficiency 16 Mitochondrial Complex 1 Deficiency, Nuclear Type 16
Cranioectodermal Dysplasia 4	CED4 Sensenbrenner Syndrome 4 Dysplasia, Cranioectodermal, Type 4
Achalasia-Addisonianism-Alacrima Syndrome	Allgrove Syndrome Triple-A Syndrome Achalasia-Addisonianism-Alacrimia Syndrome Alacrima-Achalasia-Adrenal Insufficiency Neurologic Disorder Triple A Syndrome Aaa Syndrome AAAS Glucocorticoid Deficiency With Achalasia Glucocorticoid Deficiency And Achalasia Addisonian-Achalasia Syndrome Hypoadrenalism With Achalasia Alacrima-Achalasia-Addisonianism Aaa Acth-Resistant Adrenal Insufficiency, Achalasia And Alacrima Achalasia Addisonianism Alacrimia Syndrome Achalasia Alacrima Syndrome Addisonian Achalasia Syndrome Achalasia-Addisonian Syndrome Achalasia-Alacrima Syndrome 2a Syndrome 3a Syndrome 4a Syndrome Adrenal Insufficiency-Achalasia-Alacrima Syndrome Double A Syndrome Quaternary A Syndrome Acth-Resistant Adrenal Insufficiency With Achalasia And Alacrima Allgrove'S Syndrome Adrenal Gland Hypofunction Adrenal Cortical Hypofunction
Hydrolethalus Syndrome 1	Hydrolethalus Syndrome HLS1 Salonen-Herva-Norio Syndrome Hls Hydrolethalus Hydrolethalus Syndrome, Type 1
Dystonia	Dystonic Disease Dystonic Disorder Dystonia Disorders Neuroleptic Dyskinesia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W039939	2-Azido-2-deoxy-D-glucose, 98%	Substrate	98.0%	Unkown
HY-RS09697	NUP62 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	NUP62	RGD	RGD:619938
Canis familiaris	NUP62	VGNC	VGNC:44059
Bos taurus	NUP62	VGNC	VGNC:106850
Mus musculus	NUP62	MGD	MGI:1351500
Others	NUP62	NCBI