2. Gene
  3. DTNB - dystrobrevin beta Gene

DTNB - dystrobrevin beta Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 1838 | Gene type: protein coding

About DTNB

Cytogenetic location: 2p23.3 Genomic coordinates (GRCh38): 2:25,377,243-25,673,577 (from NCBI)

This gene has 30 transcripts (splice variants), 45 orthologues and 36 paralogues. Ubiquitous expression in salivary gland (RPKM 3.0), brain (RPKM 2.3) and 25 other tissues.

Summary

This gene encodes dystrobrevin beta, a component of the dystrophin-associated protein complex (DPC). The DPC consists of dystrophin and several integral and peripheral membrane proteins, including dystroglycans, sarcoglycans, syntrophins and dystrobrevin alpha and beta. The DPC localizes to the sarcolemma and its disruption is associated with various forms of muscular dystrophy. Dystrobrevin beta is thought to interact with syntrophin and the DP71 short form of dystrophin. [provided by RefSeq, Mar 2016]

DTNB Products(30)

mRNA Protein Name
NM_001256303.2 NP_001243232.1 dystrobrevin beta isoform 6
NM_001256304.3 NP_001243233.1 dystrobrevin beta isoform 7
NM_001256308.2 NP_001243237.1 dystrobrevin beta isoform 8
NM_001320932.2 NP_001307861.1 dystrobrevin beta isoform 9
NM_001320933.2 NP_001307862.1 dystrobrevin beta isoform 10
NM_001320934.2 NP_001307863.1 dystrobrevin beta isoform 11
NM_001320935.2 NP_001307864.1 dystrobrevin beta isoform 12
NM_001320936.2 NP_001307865.1 dystrobrevin beta isoform 13
NM_001320937.2 NP_001307866.1 dystrobrevin beta isoform 14
NM_001351381.2 NP_001338310.1 dystrobrevin beta isoform 15
NM_001351382.2 NP_001338311.1 dystrobrevin beta isoform 16
NM_001351383.2 NP_001338312.1 dystrobrevin beta isoform 17
NM_001351384.2 NP_001338313.1 dystrobrevin beta isoform 18
NM_001351385.2 NP_001338314.1 dystrobrevin beta isoform 19
NM_001351386.2 NP_001338315.1 dystrobrevin beta isoform 20
NM_001351387.2 NP_001338316.1 dystrobrevin beta isoform 21
NM_001351388.2 NP_001338317.1 dystrobrevin beta isoform 22
NM_001351389.2 NP_001338318.1 dystrobrevin beta isoform 23
NM_001351390.2 NP_001338319.1 dystrobrevin beta isoform 24
NM_001351391.2 NP_001338320.1 dystrobrevin beta isoform 25
NM_001351392.2 NP_001338321.1 dystrobrevin beta isoform 26
NM_001351393.2 NP_001338322.1 dystrobrevin beta isoform 27
NM_001351394.2 NP_001338323.1 dystrobrevin beta isoform 28
NM_001351395.2 NP_001338324.1 dystrobrevin beta isoform 29
NM_001394686.1 NP_001381615.1 dystrobrevin beta isoform 30
NM_021907.5 NP_068707.1 dystrobrevin beta isoform 1
NM_033147.4 NP_149159.2 dystrobrevin beta isoform 2
NM_033148.4 NP_149160.1 dystrobrevin beta isoform 3
NM_183360.3 NP_899204.1 dystrobrevin beta isoform 4
NM_183361.3 NP_899205.1 dystrobrevin beta isoform 5

DTNB Protein Structure

EF-hand_2

EF-hand_2: EF hand (16 - 140)

EF-hand_3

EF-hand_3: EF-hand (144 - 232)

ZZ

ZZ: Zinc finger, ZZ type (240 - 280)

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  • 627 a.a.
Protein Preferred Names Protein Names

dystrobrevin beta

DTN-B

Related Diseases

Diseases Alias
Muscular Dystrophy

Muscular Dystrophies

Congenital Md

Congenital Muscular Dystrophy

Cmd

Mdc

Dystrophy, Muscular

Gower'S Muscular Dystrophy

Progressive Musclular Dystrophy

Pseudohypertrophic Atrophy

Pseudohypertrophic Muscle Paralysis

Pseudohypertrophic Muscular Atrophy

Pseudohypertrophic Muscular Dystrophy

Pseudohypertrophic Paralysis

Pseudomuscular Hypertrophy
Hermansky-Pudlak Syndrome

Hps

Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells

Hermanski-Pudlak Syndrome

Hermansky Pudlak Syndrome

Platelet Storage Pool Deficiency
Benign Epilepsy With Centrotemporal Spikes

Rolandic Epilepsy

Benign Rolandic Epilepsy

Epilepsy, Rolandic

Bcects

Benign Childhood Epilepsy With Centrotemporal Spike

Sylvan Seizures

Becrs

Bects

Bre

Benign Epilepsy Of Childhood With Centrotemporal Spikes

Benign Familial Epilepsy Of Childhood With Rolandic Spikes

Centrotemporal Epilepsy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-15915 DTNB 98.55% Unkown
HY-W127380 Arachidonoyl thio-PC ≥98.0% Unkown
HY-125744 Palmitoyl thio-PC / Unkown
HY-RS04036 DTNB Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus DTNB RGD RGD:1309579
Bos taurus DTNB VGNC VGNC:28232
Macaca mulatta DTNB VGNC VGNC:82136
Felis catus DTNB VGNC VGNC:61644
Mus musculus DTNB MGD MGI:1203728