SPZ1 - spermatogenic leucine zipper 1 Gene

Also Known as CILD38; NYD-TSP1; PPP1R148

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84654

About SPZ1

Cytogenetic location: 5q14.1 Genomic coordinates (GRCh38): 5:80,320,002-80,321,842 (from NCBI)

This gene has 2 transcripts (splice variants), 119 orthologues and 10 paralogues.

Summary

This gene encodes a bHLH-zip transcription factor which functions in the mitogen-activate protein kinase (MAPK) signaling pathway. Because of its role in the upregulation of cell proliferation and tumorigenesis, this gene may serve as a target for Ras-induced tumor treatments. [provided by RefSeq, Oct 2011]

SPZ1 Products (1)

mRNA Protein Name
NM_032567.4 NP_115956.3 spermatogenic leucine zipper protein 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

spermatogenic leucine zipper protein 1

  • protein phosphatase 1, regulatory subunit 148

SPZ1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SPZ1 Q9BXG8 HERC2 Homo sapiens O95714
Anti Tag CoIP
28514442
Intra
SPZ1 Q9BXG8 HERC2 Homo sapiens O95714
Anti Tag CoIP
33961781
Intra
SPZ1 Q9BXG8 DTNB Homo sapiens O60941
Validated Y2H
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Ciliary Dyskinesia, Primary, 13

  • Primary Ciliary Dyskinesia 13

  • CILD13

  • Primary Ciliary Dyskinesia 13 With Or Without Situs Inversus

  • Ciliary Dyskinesia, Primary, 13, With Or Without Situs Inversus

  • Ics13

  • Immotile Cilia Syndrome 13

  • Dyskinesia, Ciliary, Primary, 13
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13742 SPZ1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SPZ1 MGD MGI:1930801
Canis familiaris SPZ1 VGNC VGNC:46785
Felis catus SPZ1 VGNC VGNC:102333
Bos taurus SPZ1 VGNC VGNC:35263
Rattus norvegicus SPZ1 RGD RGD:1562395
Others SPZ1 NCBI