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CTNNAL1 - catenin alpha like 1 Gene

Also Known as ACRP; CLLP; alpha-CATU

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8727

About CTNNAL1

Cytogenetic location: 9q31.3 Genomic coordinates (GRCh38): 9:108,942,577-109,013,499 (from NCBI)

This gene has 5 transcripts (splice variants), 210 orthologues and 4 paralogues. Broad expression in adrenal (RPKM 101.6), ovary (RPKM 57.7) and 22 other tissues.

Summary

Predicted to enable actin filament binding activity and Cadherin binding activity. Acts upstream of or within Rho protein signal transduction. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

CTNNAL1 Products (2)

mRNA	Protein	Name
NM_001286974.2	NP_001273903.1	alpha-catulin isoform b
NM_003798.4	NP_003789.1	alpha-catulin isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21115837	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within Rho protein signal transduction	IDA IDA: Inferred from direct assay	12270917	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytosol	IDA IDA: Inferred from direct assay	12270917	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CTNNAL1 Protein Structure

Vinculin

0
200
400
600
734 a.a.

Protein Preferred Names	Protein Names
alpha-catulin	alpha-catenin-related protein

CTNNAL1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CTNNAL1	Q9UBT7	TRIM7	Homo sapiens	Q9C029	Y2H Prey Pooling	32296183
Intra	CTNNAL1	Q9UBT7	TRIM7	Homo sapiens	Q9C029	Y2H Array	32296183
Intra	CTNNAL1	Q9UBT7	DMD	Homo sapiens	P11532	Y2H Prey Pooling	32296183
Intra	CTNNAL1	Q9UBT7	DMD	Homo sapiens	P11532	Y2H Array	32296183
Intra	CTNNAL1	Q9UBT7	DMD	Homo sapiens	P11532	Validated Y2H	25416956
Intra	CTNNAL1	Q9UBT7	DMD	Homo sapiens	P11532	Y2H Prey Pooling	25416956
Intra	CTNNAL1	Q9UBT7	DMD	Homo sapiens	P11532	Anti Tag CoIP	21115837
Intra	CTNNAL1	Q9UBT7	DMD	Homo sapiens	P11532	TAP	21115837
Intra	CTNNAL1	Q9UBT7	TSC22D4	Homo sapiens	Q9Y3Q8	Y2H Prey Pooling	32296183
Intra	CTNNAL1	Q9UBT7	TSC22D4	Homo sapiens	Q9Y3Q8	Validated Y2H	32296183
Intra	CTNNAL1	Q9UBT7	TSC22D4	Homo sapiens	Q9Y3Q8	Y2H Array	32296183
Intra	CTNNAL1	Q9UBT7	ZBED1	Homo sapiens	O96006	Y2H Array	32296183
Intra	CTNNAL1	Q9UBT7	ZBED1	Homo sapiens	O96006	Y2H Prey Pooling	32296183
Intra	CTNNAL1	Q9UBT7	DTNB	Homo sapiens	O60941	TAP	21115837
Intra	CTNNAL1	Q9UBT7	BRME1	Homo sapiens	Q0VDD7	Validated Y2H	25416956
Intra	CTNNAL1	Q9UBT7	BRME1	Homo sapiens	Q0VDD7	Y2H Prey Pooling	25416956
Intra	CTNNAL1	Q9UBT7	CBY2	Homo sapiens	Q8NA61	Y2H Prey Pooling	25416956
Intra	CTNNAL1	Q9UBT7	SERTAD3	Homo sapiens	Q9UJW9	Validated Y2H	32296183
Intra	CTNNAL1	Q9UBT7	SERTAD3	Homo sapiens	Q9UJW9	Y2H Array	32296183
Intra	CTNNAL1	Q9UBT7	SERTAD3	Homo sapiens	Q9UJW9	Y2H Prey Pooling	32296183
Intra	CTNNAL1	Q9UBT7	DTNA	Homo sapiens	Q9Y4J8	Far-WB	21115837
Intra	CTNNAL1	Q9UBT7	DTNA	Homo sapiens	Q9Y4J8	TAP	21115837
Intra	CTNNAL1	Q9UBT7	DTNA	Homo sapiens	Q9Y4J8	Anti Tag CoIP	21115837
Intra	CTNNAL1	Q9UBT7	DTNA	Homo sapiens	Q9Y4J8	Pull Down	21115837
Intra	CTNNAL1	Q9UBT7	USH1C	Homo sapiens	Q9Y6N9	Validated Y2H	25416956
Intra	CTNNAL1	Q9UBT7	PLCB2	Homo sapiens	Q00722	Far-WB	21115837
Intra	CTNNAL1	Q9UBT7	PLCB2	Homo sapiens	Q00722	TAP	21115837
Intra	CTNNAL1	Q9UBT7	RNF135	Homo sapiens	Q8IUD6	Y2H Prey Pooling	32296183
Intra	CTNNAL1	Q9UBT7	RNF135	Homo sapiens	Q8IUD6	Y2H Array	32296183
Intra	CTNNAL1	Q9UBT7	RNF135	Homo sapiens	Q8IUD6	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome 1	Eec Syndrome Rudiger Syndrome 1 Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip-Palate Syndrome 1 EEC1 Eec Syndrome 1 Eec Syndrome-1 Walker-Clodius Syndrome Ectrodactyly-Ectodermal Dysplasia-Cleft Lip/Palate Syndrome Eec Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip-Palate Syndrome Ectrodactyly-Ectodermal Dysplasia-Clefting Syndrome Ectrodactyly-Cleft Lip/Palate Syndrome Ectrodactyly-Ectodermal Dysplasia-Cleft Lip/Cleft Palate Ectrodactyly-Ectodermal Dysplasia-Clefting Syndrome Ectrodactyly, Ectodermal Dysplasia, Clefting Syndrome Ectrodactyly-Cleft Lip-Palate Syndrome Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome
Perrault Syndrome	Gonadal Dysgenesis, Xx Type, With Deafness Ovarian Dysgenesis With Sensorineural Deafness Gonadal Dysgenesis, Xx Type Gonadal Dysgenesis With Auditory Dysfunction, Autosomal Recessive Inheritance Gonadal Dysgenesis With Sensorineural Deafness, Autosomal Recessive Inheritance Xx Gonodal Dysgenesis-Deafness Syndrome Xx Gonodal Dysgenesis-Hearing Loss Syndrome Gonadal Dysgenesis Xx Type Deafness
Hirschsprung Disease 1	Hirschsprung Disease Aganglionic Megacolon Hscr Hirschsprung'S Disease Congenital Megacolon Congenital Intestinal Aganglionosis Colonic Aganglionosis Hirschsprung Disease, Susceptibility To, 1 Hirschsprung Disease, Protection Against HSCR1 Mgc Pelvirectal Achalasia Total Intestinal Aganglionosis Megacolon, Aganglionic Macrocolon Hscr 1 Hirschsprung Disease Type 1 Hirschsprung Disease, Type 1 Congenital Dilatation Of Colon Aganglionosis Congenital Aganglionic Megacolon Aganglionosis Of Colon Bowel Aganglionosis Colon Aganglionosis Hirschsprung Megacolon

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03305	CTNNAL1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CTNNAL1	MGD	MGI:1859649
Bos taurus	CTNNAL1	VGNC	VGNC:27801
Rattus norvegicus	CTNNAL1	RGD	RGD:1311434
Felis catus	CTNNAL1	VGNC	VGNC:61255
Canis familiaris	CTNNAL1	VGNC	VGNC:39699
Macaca mulatta	CTNNAL1	VGNC	VGNC:71544
Others	CTNNAL1	NCBI