SERTAD3 - SERTA domain containing 3 Gene

Also Known as RBT1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 29946

Summary

The protein encoded by this gene was identified in a yeast two-hybrid assay employing the second subunit of human replication protein A as bait. It is localized to the nucleus and its expression is significantly higher in Cancer cell lines compared to normal cell lines. This protein has also been shown to be a strong transcriptional co-activator. Alternative splicing has been observed at this locus and two variants, both encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
Ubiquitous expression in placenta (RPKM 11.9), prostate (RPKM 10.6) and 25 other tissues.

SERTAD3 Products (2)

mRNA Protein Name
NM_013368.4 NP_037500.2 SERTA domain-containing protein 3
NM_203344.3 NP_976219.1 SERTA domain-containing protein 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
10982866 GOA
Biological Process GO Annotation Evidence Verweise Source
acts upstream of or within negative regulation of cell growth IDA
IDA: Inferred from direct assay
16098148 GOA
involved in regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
10982866 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in nucleus IDA
IDA: Inferred from direct assay
10982866 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SERTAD3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
SERTAD3 Q9UJW9 HEMK1 Homo sapiens Q9Y5R4
Validated Y2H
32296183
Intra
SERTAD3 Q9UJW9 ANKRD11 Homo sapiens X5D778
Validated Y2H
32296183
Intra
SERTAD3 Q9UJW9 FBXO44 Homo sapiens Q9H4M3
Y2H Array
25416956
Intra
SERTAD3 Q9UJW9 SPG11 Homo sapiens Q96JI7
Validated Y2H
25416956
Intra
SERTAD3 Q9UJW9 SPG11 Homo sapiens Q96JI7
Y2H Array
25416956
Intra
SERTAD3 Q9UJW9 KPNA2 Homo sapiens P52292
Y2H Array
31515488
Intra
SERTAD3 Q9UJW9 SNRPB Homo sapiens P14678-2
MAPPIT
32296183
Intra
SERTAD3 Q9UJW9 UBL5 Homo sapiens Q9BZL1
MAPPIT
32296183
Intra
SERTAD3 Q9UJW9 RPA2 Homo sapiens P15927
Anti Bait CoIP
10982866
Intra
SERTAD3 Q9UJW9 RPA2 Homo sapiens P15927
Confocal
10982866
Intra
SERTAD3 Q9UJW9 RPA2 Homo sapiens P15927
Y2H
10982866
Intra
SERTAD3 Q9UJW9 USHBP1 Homo sapiens Q8N6Y0
Y2H Pooling
16189514
Intra
SERTAD3 Q9UJW9 USHBP1 Homo sapiens Q8N6Y0
Y2H Array
19060904
Intra
SERTAD3 Q9UJW9 USHBP1 Homo sapiens Q8N6Y0
Y2H Pooling
19060904
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS12731 SERTAD1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12732 SERTAD2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12733 SERTAD4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown