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UBL5 - ubiquitin like 5 Gene

Also Known as HUB1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 59286

About UBL5

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:9,827,918-9,830,115 (from NCBI)

This gene has 8 transcripts (splice variants) and 189 orthologues. Ubiquitous expression in kidney (RPKM 86.7), adrenal (RPKM 83.4) and 25 other tissues.

Summary

This gene encodes a member of a group of proteins similar to ubiquitin. The encoded protein is not thought to degrade proteins like ubiquitin but to affect their function through being bound to target proteins by an isopeptide bond. The gene product has been studied as a link to predisposition to obesity based on its expression in Psammomys obesus, the fat sand rat, which is an animal model for obesity studies. Variation in this gene was found to be significantly associated with some metabolic traits (PMID: 15331561) but not associated with childhood obesity (PMID: 19189687). Pseudogenes of this gene are located on chromosomes 3, 5 and 17. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2013]

UBL5 Products (2)

mRNA	Protein	Name
NM_001048241.3	NP_001041706.1	ubiquitin-like protein 5
NM_024292.4	NP_077268.1	ubiquitin-like protein 5

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15620657	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	11161819	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UBL5 Protein Structure

ubiquitin

0
73 a.a.

Protein Preferred Names	Protein Names
ubiquitin-like protein 5	beacon

UBL5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	UBL5	Q9BZL1	KRTAP10-8	Homo sapiens	P60410	Y2H Prey Pooling	32296183
Intra	UBL5	Q9BZL1	KRTAP10-8	Homo sapiens	P60410	Y2H Array	32296183
Intra	UBL5	Q9BZL1	BEND7	Homo sapiens	Q8N7W2-2	Y2H Prey Pooling	32296183
Intra	UBL5	Q9BZL1	BEND7	Homo sapiens	Q8N7W2-2	Y2H Array	32296183
Intra	UBL5	Q9BZL1	CCDC196	Homo sapiens	A0A1B0GWI1	Y2H Prey Pooling	32296183
Intra	UBL5	Q9BZL1	CCDC196	Homo sapiens	A0A1B0GWI1	Y2H Array	32296183
Intra	UBL5	Q9BZL1	PAX4	Homo sapiens	Q3KNR5	Y2H Prey Pooling	32296183
Intra	UBL5	Q9BZL1	PAX4	Homo sapiens	Q3KNR5	Y2H Array	32296183
Intra	UBL5	Q9BZL1	KRTAP13-3	Homo sapiens	Q3SY46	Y2H Prey Pooling	32296183
Intra	UBL5	Q9BZL1	KRTAP13-3	Homo sapiens	Q3SY46	Y2H Array	32296183
Intra	UBL5	Q9BZL1	NRIP3	Homo sapiens	Q9NQ35	Validated Y2H	32296183
Intra	UBL5	Q9BZL1	NRIP3	Homo sapiens	Q9NQ35	Y2H Array	32296183
Intra	UBL5	Q9BZL1	NRIP3	Homo sapiens	Q9NQ35	Y2H Prey Pooling	32296183
Intra	UBL5	Q9BZL1	NFYA	Homo sapiens	P23511-2	Y2H Prey Pooling	32296183
Intra	UBL5	Q9BZL1	NFYA	Homo sapiens	P23511-2	Y2H Array	32296183
Intra	UBL5	Q9BZL1	TRIM39	Homo sapiens	Q9HCM9-2	Validated Y2H	32296183
Intra	UBL5	Q9BZL1	TRIM39	Homo sapiens	Q9HCM9-2	Y2H Prey Pooling	32296183
Intra	UBL5	Q9BZL1	TRIM39	Homo sapiens	Q9HCM9-2	Y2H Array	32296183
Intra	UBL5	Q9BZL1	SEPTIN2	Homo sapiens	Q15019-3	Y2H Array	32296183
Intra	UBL5	Q9BZL1	SEPTIN2	Homo sapiens	Q15019-3	Y2H Prey Pooling	32296183
Intra	UBL5	Q9BZL1	C1QTNF1	Homo sapiens	Q9BXJ1-2	Y2H Prey Pooling	32296183
Intra	UBL5	Q9BZL1	C1QTNF1	Homo sapiens	Q9BXJ1-2	Y2H Array	32296183
Intra	UBL5	Q9BZL1	TLE5	Homo sapiens	Q08117-2	Y2H Prey Pooling	32296183
Intra	UBL5	Q9BZL1	TLE5	Homo sapiens	Q08117-2	Y2H Array	32296183
Intra	UBL5	Q9BZL1	CTAG1A	Homo sapiens	P78358	Y2H Prey Pooling	32296183
Intra	UBL5	Q9BZL1	CTAG1A	Homo sapiens	P78358	Y2H Array	32296183
Intra	UBL5	Q9BZL1	SPATC1L	Homo sapiens	Q9H0A9-2	Validated Y2H	32296183
Intra	UBL5	Q9BZL1	SPATC1L	Homo sapiens	Q9H0A9-2	Y2H Array	32296183
Intra	UBL5	Q9BZL1	SPATC1L	Homo sapiens	Q9H0A9-2	Y2H Prey Pooling	32296183
Intra	UBL5	Q9BZL1	SF1	Homo sapiens	Q15637-4	Y2H Array	32296183
Intra	UBL5	Q9BZL1	SF1	Homo sapiens	Q15637-4	Y2H Prey Pooling	32296183
Intra	UBL5	Q9BZL1	ZFP41	Homo sapiens	Q8N8Y5	Y2H Prey Pooling	32296183
Intra	UBL5	Q9BZL1	ZFP41	Homo sapiens	Q8N8Y5	Y2H Array	32296183
Intra	UBL5	Q9BZL1	CERCAM	Homo sapiens	Q5T4B2	Y2H Prey Pooling	32296183
Intra	UBL5	Q9BZL1	MBD3L1	Homo sapiens	Q8WWY6	Y2H Prey Pooling	32296183
Intra	UBL5	Q9BZL1	MBD3L1	Homo sapiens	Q8WWY6	Y2H Array	32296183
Intra	UBL5	Q9BZL1	TEX35	Homo sapiens	Q5T0J7-2	Y2H Prey Pooling	32296183
Intra	UBL5	Q9BZL1	TEX35	Homo sapiens	Q5T0J7-2	Y2H Array	32296183
Intra	UBL5	Q9BZL1	CCDC28B	Homo sapiens	Q9BUN5-3	Y2H Array	32296183
Intra	UBL5	Q9BZL1	CCDC28B	Homo sapiens	Q9BUN5-3	Y2H Prey Pooling	32296183
Intra	UBL5	Q9BZL1	SPANXB1	Homo sapiens	Q9NS25	Validated Y2H	32296183
Intra	UBL5	Q9BZL1	SPANXB1	Homo sapiens	Q9NS25	Y2H Array	32296183
Intra	UBL5	Q9BZL1	SPANXB1	Homo sapiens	Q9NS25	Y2H Prey Pooling	32296183
Intra	UBL5	Q9BZL1	THAP3	Homo sapiens	Q8WTV1	Y2H Array	32296183
Intra	UBL5	Q9BZL1	THAP3	Homo sapiens	Q8WTV1	Y2H Prey Pooling	32296183
Intra	UBL5	Q9BZL1	GCSAML	Homo sapiens	Q5JQS6	Y2H Prey Pooling	32296183
Intra	UBL5	Q9BZL1	GCSAML	Homo sapiens	Q5JQS6	Y2H Array	32296183
Intra	UBL5	Q9BZL1	ZNF124	Homo sapiens	Q15973	Y2H Array	32296183
Intra	UBL5	Q9BZL1	ZNF124	Homo sapiens	Q15973	Y2H Prey Pooling	32296183
Intra	UBL5	Q9BZL1	BIN3	Homo sapiens	Q9NQY0	Y2H Prey Pooling	32296183
Intra	UBL5	Q9BZL1	BIN3	Homo sapiens	Q9NQY0	Validated Y2H	32296183
Intra	UBL5	Q9BZL1	BIN3	Homo sapiens	Q9NQY0	Y2H Array	32296183
Intra	UBL5	Q9BZL1	SART1	Homo sapiens	O43290	Anti Tag CoIP	25092792
Intra	UBL5	Q9BZL1	ZNF618	Homo sapiens	Q5T7W0	Y2H Prey Pooling	32296183
Intra	UBL5	Q9BZL1	ZNF618	Homo sapiens	Q5T7W0	Y2H Array	32296183
Intra	UBL5	Q9BZL1	PHACTR3	Homo sapiens	Q96KR7	Y2H Array	32296183
Intra	UBL5	Q9BZL1	PHACTR3	Homo sapiens	Q96KR7	Y2H Prey Pooling	32296183
Intra	UBL5	Q9BZL1	PINX1	Homo sapiens	Q96BK5	Y2H Prey Pooling	32296183
Intra	UBL5	Q9BZL1	PINX1	Homo sapiens	Q96BK5	Y2H Array	32296183
Intra	UBL5	Q9BZL1	HMGXB4	Homo sapiens	Q9UGU5	Y2H Array	32296183
Intra	UBL5	Q9BZL1	HMGXB4	Homo sapiens	Q9UGU5	Y2H Prey Pooling	32296183
Intra	UBL5	Q9BZL1	HMGXB4	Homo sapiens	Q9UGU5	Validated Y2H	32296183
Intra	UBL5	Q9BZL1	LENG1	Homo sapiens	Q96BZ8	Y2H Array	32296183
Intra	UBL5	Q9BZL1	LENG1	Homo sapiens	Q96BZ8	Y2H Prey Pooling	32296183
Intra	UBL5	Q9BZL1	HOXA1	Homo sapiens	P49639	Y2H Array	32296183
Intra	UBL5	Q9BZL1	HOXA1	Homo sapiens	P49639	Y2H Prey Pooling	32296183
Intra	UBL5	Q9BZL1	PSME2	Homo sapiens	Q9UL46	Y2H Prey Pooling	32296183
Intra	UBL5	Q9BZL1	PSME2	Homo sapiens	Q9UL46	Validated Y2H	32296183
Intra	UBL5	Q9BZL1	PSME2	Homo sapiens	Q9UL46	Y2H Array	32296183
Intra	UBL5	Q9BZL1	FAM50B	Homo sapiens	Q9Y247	Y2H Prey Pooling	32296183
Intra	UBL5	Q9BZL1	FAM50B	Homo sapiens	Q9Y247	Validated Y2H	32296183
Intra	UBL5	Q9BZL1	FAM50B	Homo sapiens	Q9Y247	Y2H Array	32296183
Intra	UBL5	Q9BZL1	HID1	Homo sapiens	Q8IV36	Y2H Prey Pooling	32296183
Intra	UBL5	Q9BZL1	HID1	Homo sapiens	Q8IV36	Y2H Array	32296183
Intra	UBL5	Q9BZL1	NME4	Homo sapiens	O00746	Y2H Prey Pooling	32296183
Intra	UBL5	Q9BZL1	NME4	Homo sapiens	O00746	Y2H Array	32296183
Intra	UBL5	Q9BZL1	PRMT8	Homo sapiens	Q9NR22	Validated Y2H	32296183
Intra	UBL5	Q9BZL1	PRMT8	Homo sapiens	Q9NR22	Y2H Array	32296183
Intra	UBL5	Q9BZL1	PRMT8	Homo sapiens	Q9NR22	Y2H Prey Pooling	32296183
Intra	UBL5	Q9BZL1	SERTAD3	Homo sapiens	Q9UJW9	Y2H Prey Pooling	32296183
Intra	UBL5	Q9BZL1	SERTAD3	Homo sapiens	Q9UJW9	Validated Y2H	32296183
Intra	UBL5	Q9BZL1	SERTAD3	Homo sapiens	Q9UJW9	Y2H Array	32296183
Intra	UBL5	Q9BZL1	SMCP	Homo sapiens	P49901	Y2H Array	32296183
Intra	UBL5	Q9BZL1	SMCP	Homo sapiens	P49901	Y2H Prey Pooling	32296183
Intra	UBL5	Q9BZL1	WDR83	Homo sapiens	Q9BRX9	Anti Tag CoIP	22365833
Intra	UBL5	Q9BZL1	HESX1	Homo sapiens	Q9UBX0	Validated Y2H	32296183
Intra	UBL5	Q9BZL1	HESX1	Homo sapiens	Q9UBX0	Y2H Array	32296183
Intra	UBL5	Q9BZL1	HESX1	Homo sapiens	Q9UBX0	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

UBL5 Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P810832	UBL5 Antibody (YA10075)	WB	Human, Mouse

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS10557	PIN1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS15376	UBL5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22351	Ubl5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28873	Ubl5 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	UBL5	RGD	RGD:1564644
Mus musculus	UBL5	MGD	MGI:1913427
Felis catus	UBL5	VGNC	VGNC:66775
Macaca mulatta	UBL5	VGNC	VGNC:82266
Canis familiaris	UBL5	VGNC	VGNC:48078
Others	UBL5	NCBI