2. Gene
  3. PRMT8 - protein arginine methyltransferase 8 Gene

PRMT8 - protein arginine methyltransferase 8 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as HRMT1L3; HRMT1L4

Gene ID: 56341 | Gene type: protein coding

About PRMT8

Cytogenetic location: 12p13.32 Genomic coordinates (GRCh38): 12:3,381,349-3,593,973 (from NCBI)

This gene has 4 transcripts (splice variants), 281 orthologues and 7 paralogues. Biased expression in brain (RPKM 5.7), testis (RPKM 0.8) and 1 other tissue.

Summary

Arginine methylation is a widespread posttranslational modification mediated by arginine methyltransferases, such as PRMT8. Arginine methylation is involved in a number of cellular processes, including DNA repair, RNA transcription, signal transduction, protein compartmentalization, and possibly protein translation (Lee et al., 2005 [PubMed 16051612]).[supplied by OMIM, Mar 2008]

PRMT8 Products(9)

mRNA Protein Name
NM_001256536.1 NP_001243465.1 protein arginine N-methyltransferase 8 isoform 2
XM_047429157.1 XP_047285113.1 protein arginine N-methyltransferase 8 isoform X3
XM_047429159.1 XP_047285115.1 protein arginine N-methyltransferase 8 isoform X5
XM_017019644.2 XP_016875133.1 protein arginine N-methyltransferase 8 isoform X1
XM_017019645.1 XP_016875134.1 protein arginine N-methyltransferase 8 isoform X2
XM_047429158.1 XP_047285114.1 protein arginine N-methyltransferase 8 isoform X4
NM_001256537.1
NR_046301.1
NM_019854.5 NP_062828.3 protein arginine N-methyltransferase 8 isoform 1

PRMT8 Protein Structure

PrmA

PrmA: Ribosomal protein L11 methyltransferase (PrmA) (108 - 184)

  • 0
  • 100
  • 200
  • 300
  • 394 a.a.
Protein Preferred Names Protein Names

protein arginine N-methyltransferase 8

HMT1 hnRNP methyltransferase-like 3

arginine methyltransferase 8

heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 4

protein arginine N-methyltransferase 4

Related Agents

Pre-clinical Phase
Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-19615 MS023 Inhibitor 99.73% Unkown
HY-12970A EPZ020411 hydrochloride Inhibitor 98.15% Unkown
HY-12970 EPZ020411 Inhibitor 98.06% Unkown
HY-19615B MS023 dihydrochloride Inhibitor 99.78% Unkown
HY-100360 MS049 Inhibitor ≥98.0% Unkown
HY-128717B GSK3368715 trihydrochloride Inhibitor / Unkown
HY-146810 PRMT4-IN-1 Inhibitor / Unkown
HY-161334 CARM1-IN-4 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PRMT8 RGD RGD:1587677
Mus musculus PRMT8 MGD MGI:3043083
Felis catus PRMT8 VGNC VGNC:67652
Bos taurus PRMT8 VGNC VGNC:33353
Canis familiaris PRMT8 VGNC VGNC:45001
Macaca mulatta PRMT8 VGNC VGNC:76360