SYNCRIP - synaptotagmin binding cytoplasmic RNA interacting protein Gene

Also Known as PP68; NSAP1; GRYRBP; HNRNPQ; HNRPQ1; GRY-RBP; hnRNP-Q

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10492

About SYNCRIP

Cytogenetic location: 6q14.3 Genomic coordinates (GRCh38): 6:85,607,784-85,643,870 (from NCBI)

This gene has 21 transcripts (splice variants), 279 orthologues, 24 paralogues and is associated with 2 phenotypes. Ubiquitous expression in thyroid (RPKM 21.7), appendix (RPKM 18.1) and 25 other tissues.

Summary

This gene encodes a member of the cellular heterogeneous nuclear ribonucleoprotein (hnRNP) family. hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA (hnRNA) and regulate alternative splicing, polyadenylation, and Other aspects of mRNA metabolism and transport. The encoded protein plays a role in multiple aspects of mRNA maturation and is associated with several multiprotein complexes including the apoB RNA editing-complex and survival of motor neurons (SMN) complex. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 20. [provided by RefSeq, Dec 2011]

SYNCRIP Products (8)

mRNA	Protein	Name
NM_001159673.2	NP_001153145.1	heterogeneous nuclear ribonucleoprotein Q isoform 2
NM_001159674.2	NP_001153146.1	heterogeneous nuclear ribonucleoprotein Q isoform 3
NM_001159675.1	NP_001153147.1	heterogeneous nuclear ribonucleoprotein Q isoform 4
NM_001159676.1	NP_001153148.1	heterogeneous nuclear ribonucleoprotein Q isoform 5
NM_001159677.2	NP_001153149.1	heterogeneous nuclear ribonucleoprotein Q isoform 6
NM_001253771.2	NP_001240700.1	heterogeneous nuclear ribonucleoprotein Q isoform 7
NM_001410938.1	NP_001397867.1	heterogeneous nuclear ribonucleoprotein Q isoform 8
NM_006372.5	NP_006363.4	heterogeneous nuclear ribonucleoprotein Q isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12674497	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in CRD-mediated mRNA stabilization	IDA IDA: Inferred from direct assay	11051545	GOA
involved in CRD-mediated mRNA stabilization	IMP IMP: Inferred from mutant phenotype	19029303	GOA
involved in cellular response to type II interferon	IDA IDA: Inferred from direct assay	15479637	GOA
involved in mRNA modification	IDA IDA: Inferred from direct assay	11134005	GOA
involved in negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	IDA IDA: Inferred from direct assay	11051545	GOA
involved in negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IDA IDA: Inferred from direct assay	12881431	GOA
involved in negative regulation of translation	IDA IDA: Inferred from direct assay	23071094	GOA
involved in negative regulation of translation	IMP IMP: Inferred from mutant phenotype	15479637	GOA
involved in positive regulation of cytoplasmic translation	IDA IDA: Inferred from direct assay	11051545	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of CRD-mediated mRNA stability complex	IDA IDA: Inferred from direct assay	19029303	GOA
part of CRD-mediated mRNA stability complex	IPI IPI: Inferred from physical interaction	19029303	GOA
part of GAIT complex	IDA IDA: Inferred from direct assay	15479637	GOA
part of catalytic step 2 spliceosome	IDA IDA: Inferred from direct assay	11991638	GOA
located in cytosol	IDA IDA: Inferred from direct assay	11051545	GOA
part of mCRD-mediated mRNA stability complex	IPI IPI: Inferred from physical interaction	11051545	GOA
located in nucleus	IDA IDA: Inferred from direct assay	12881431	GOA
part of ribonucleoprotein complex	IDA IDA: Inferred from direct assay	15479637	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SYNCRIP Protein Structure

RRM_1

0
100
200
300
400
500
623 a.a.

Protein Preferred Names	Protein Names
heterogeneous nuclear ribonucleoprotein Q	NS1-associated protein 1

SYNCRIP Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SYNCRIP	O60506	PRMT8	Homo sapiens	Q9NR22-2	Y2H Prey Pooling	25416956
Intra	SYNCRIP	O60506	HNRNPD	Homo sapiens	Q14103-4	Y2H	12674497
Intra	SYNCRIP	O60506	HABP4	Homo sapiens	Q5JVS0	Pull Down	19523114
Intra	SYNCRIP	O60506	HABP4	Homo sapiens	Q5JVS0	Y2H	19523114
Intra	SYNCRIP	O60506	PRMT8	Homo sapiens	Q9NR22	Y2H Array	29892012
Intra	SYNCRIP	O60506	PRMT1	Homo sapiens	Q99873	Y2H	23455924
Intra	SYNCRIP	O60506	PRMT1	Homo sapiens	Q99873	Anti Tag CoIP	23455924

Cross: Cross-species interaction Intra: Intraspecies interaction

SYNCRIP Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82093	hnRNP Q Antibody (YA1838)	WB, IHC-P, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Non-Specific Syndromic Intellectual Disability	Complex Neurodevelopmental Disorder
Spinal Muscular Atrophy	Sma 5q Sma Proximal Sma Sma-Associated Sma Spinal Amyotrophies Spinal Amyotrophy Spinal Muscle Degeneration Spinal Muscle Wasting Muscular Atrophy Spinal Atrophy, Muscular, Spinal Hereditary Motor Neuronopathy Progressive Muscular Atrophy Sma - [Spinal Muscular Atrophy]
Myoblastoma	Benign Granular Cell Tumor
Muscular Atrophy	Muscle Wasting Amyotrophia Wasting - Muscle Skeletal Muscle Atrophy
Treacher Collins Syndrome 1	Treacher Collins Syndrome Mandibulofacial Dysostosis Treacher Collins-Franceschetti Syndrome Tcof Tcs Mfd1 Franceschetti-Klein Syndrome TCS1 Franceschetti Syndrome Franceschetti-Zwahlen-Klein Syndrome Zygoauromandibular Dysplasia Treacher-Collins Syndrome Mandibulofacial Dysostosis Without Limb Anomalies Bilateral And Symmetric Oto-Mandibular Dysplasia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14082	SYNCRIP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SYNCRIP	MGD	MGI:1891690
Canis familiaris	SYNCRIP	VGNC	VGNC:47024
Rattus norvegicus	SYNCRIP	RGD	RGD:1305683
Felis catus	SYNCRIP	VGNC	VGNC:65881
Bos taurus	SYNCRIP	VGNC	VGNC:35518
Macaca mulatta	SYNCRIP	VGNC	VGNC:78141
Others	SYNCRIP	NCBI