HABP4 - hyaluronan binding protein 4 Gene

Also Known as IHABP4; IHABP-4; Ki-1/57; SERBP1L

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 22927

About HABP4

Cytogenetic location: 9q22.32 Genomic coordinates (GRCh38): 9:96,450,102-96,491,336 (from NCBI)

This gene has 3 transcripts (splice variants), 183 orthologues and 1 paralogue. Broad expression in brain (RPKM 24.4), testis (RPKM 16.9) and 22 other tissues.

Summary

Enables SUMO binding activity. Involved in PML body organization; negative regulation of DNA binding activity; and positive regulation of gene expression. Located in several cellular components, including Golgi apparatus; cytoplasmic stress granule; and nuclear lumen. [provided by Alliance of Genome Resources, Apr 2022]

HABP4 Products (1)

mRNA Protein Name
NM_014282.4 NP_055097.2 intracellular hyaluronan-binding protein 4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables SUMO binding IDA
IDA: Inferred from direct assay
28695742 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15862299 GOA
Biological Process GO Annotation Evidence References Source
involved in PML body organization IDA
IDA: Inferred from direct assay
28695742 GOA
involved in negative regulation of DNA binding IDA
IDA: Inferred from direct assay
15862299 GOA
involved in positive regulation of RNA splicing IMP
IMP: Inferred from mutant phenotype
19523114 GOA
involved in positive regulation of translational initiation IMP
IMP: Inferred from mutant phenotype
21771594 GOA
Cellular Component GO Annotation Evidence References Source
located in Cajal body IDA
IDA: Inferred from direct assay
19523114 GOA
located in Gemini of coiled bodies IDA
IDA: Inferred from direct assay
19523114 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
16879614 GOA
located in cytoplasmic stress granule IDA
IDA: Inferred from direct assay
21771594 GOA
located in nuclear speck IDA
IDA: Inferred from direct assay
19523114 GOA
located in nucleolus IDA
IDA: Inferred from direct assay
19523114 GOA
located in nucleus IDA
IDA: Inferred from direct assay
16879614 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HABP4 Protein Structure

HABP4_PAI-RBP1

HABP4_PAI-RBP1: Hyaluronan / mRNA binding family (212 - 316)

  • 0
  • 100
  • 200
  • 300
  • 413 a.a.
Protein Preferred Names Protein Names

intracellular hyaluronan-binding protein 4

  • chromodomain helicase DNA binding protein 3 interacting protein

HABP4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
HABP4 Q5JVS0 SRSF9 Homo sapiens Q13242
Pull Down
19523114
Intra
HABP4 Q5JVS0 PRMT1 Homo sapiens Q99873
Y2H Pooling
16169070
Intra
HABP4 Q5JVS0 PRMT1 Homo sapiens Q99873
Pull Down
16169070
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05983 HABP4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22544 Habp4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris HABP4 VGNC VGNC:41581
Bos taurus HABP4 VGNC VGNC:29736
Rattus norvegicus HABP4 RGD RGD:1306486
Macaca mulatta HABP4 VGNC VGNC:73183
Mus musculus HABP4 MGD MGI:1891713
Felis catus HABP4 VGNC VGNC:62745
Others HABP4 NCBI