SRSF9 - serine and arginine rich splicing factor 9 Gene

Also Known as SFRS9; SRp30c

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8683

About SRSF9

Cytogenetic location: 12q24.31 Genomic coordinates (GRCh38): 12:120,461,672-120,469,748 (from NCBI)

This gene has 6 transcripts (splice variants), 209 orthologues and 8 paralogues. Ubiquitous expression in testis (RPKM 59.8), lymph node (RPKM 55.2) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding Other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two pseudogenes, one on chromosome 15 and the Other on chromosome 21, have been found for this gene. [provided by RefSeq, Sep 2010]

SRSF9 Products (1)

mRNA	Protein	Name
NM_003769.3	NP_003760.1	serine/arginine-rich splicing factor 9

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10196175	GOA
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	10749975	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of mRNA splicing, via spliceosome	IDA IDA: Inferred from direct assay	15009664	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SRSF9 Protein Structure

RRM_1

0
100
200
221 a.a.

Protein Preferred Names	Protein Names
serine/arginine-rich splicing factor 9	SR splicing factor 9

SRSF9 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SRSF9	Q13242	RNPS1	Homo sapiens	Q15287	Validated Y2H	32296183
Intra	SRSF9	Q13242	HABP4	Homo sapiens	Q5JVS0	Y2H	19523114

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Spinocerebellar Ataxia 31	Spinocerebellar Ataxia Type 31 SCA31 Spinocerebellar Ataxia 16q22-Linked Spinocerebellar Ataxia, 16q22-Linked Pure Spinocerebellar Ataxia Japanese Type Sca4 Pure Japanese Type Ataxia, Spinocerebellar, Type 31

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13799	SRSF9 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21769	Srsf9 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SRSF9	RGD	RGD:1309495
Felis catus	SRSF9	VGNC	VGNC:80494
Canis familiaris	SRSF9	VGNC	VGNC:52970
Mus musculus	SRSF9	MGD	MGI:104896
Bos taurus	SRSF9	VGNC	VGNC:52832
Macaca mulatta	SRSF9	VGNC	VGNC:100109
Others	SRSF9	NCBI