2. Gene
  3. SRSF9 - serine and arginine rich splicing factor 9 Gene

SRSF9 - serine and arginine rich splicing factor 9 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as SFRS9; SRp30c

Gene ID: 8683 | Gene type: protein coding

About SRSF9

Cytogenetic location: 12q24.31 Genomic coordinates (GRCh38): 12:120,461,672-120,469,748 (from NCBI)

This gene has 6 transcripts (splice variants), 209 orthologues and 8 paralogues. Ubiquitous expression in testis (RPKM 59.8), lymph node (RPKM 55.2) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two pseudogenes, one on chromosome 15 and the other on chromosome 21, have been found for this gene. [provided by RefSeq, Sep 2010]

SRSF9 Products(1)

mRNA Protein Name
NM_003769.3 NP_003760.1 serine/arginine-rich splicing factor 9

SRSF9 Protein Structure

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (16 - 83)

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (113 - 174)

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  • 221 a.a.
Protein Preferred Names Protein Names

serine/arginine-rich splicing factor 9

SR splicing factor 9

Related Diseases

Diseases Alias
Spinocerebellar Ataxia 31

Spinocerebellar Ataxia Type 31

SCA31

Spinocerebellar Ataxia 16q22-Linked

Spinocerebellar Ataxia, 16q22-Linked

Pure Spinocerebellar Ataxia Japanese Type

Sca4 Pure Japanese Type

Ataxia, Spinocerebellar, Type 31
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13799 SRSF9 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus SRSF9 RGD RGD:1309495
Felis catus SRSF9 VGNC VGNC:80494
Canis familiaris SRSF9 VGNC VGNC:52970
Mus musculus SRSF9 MGD MGI:104896
Bos taurus SRSF9 VGNC VGNC:52832
Macaca mulatta SRSF9 VGNC VGNC:100109