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RNPS1 - RNA binding protein with serine rich domain 1 Gene

Also Known as E5.1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10921

About RNPS1

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:2,253,116-2,268,126 (from NCBI)

This gene has 26 transcripts (splice variants) and 252 orthologues. Ubiquitous expression in bone marrow (RPKM 25.4), testis (RPKM 24.3) and 25 other tissues.

Summary

This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. This protein contains many serine residues. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

RNPS1 Products (5)

mRNA	Protein	Name
NM_001286625.1	NP_001273554.1	RNA-binding protein with serine-rich domain 1 isoform a
NM_001286626.2	NP_001273555.1	RNA-binding protein with serine-rich domain 1 isoform b
NM_001286627.2	NP_001273556.1	RNA-binding protein with serine-rich domain 1 isoform c
NM_006711.5	NP_006702.1	RNA-binding protein with serine-rich domain 1 isoform a
NM_080594.4	NP_542161.1	RNA-binding protein with serine-rich domain 1 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
NOT enables RNA binding	IDA IDA: Inferred from direct assay	22388736	GOA
enables mRNA 3'-UTR binding	IDA IDA: Inferred from direct assay	11546874	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11477570	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of mRNA splicing, via spliceosome	IDA IDA: Inferred from direct assay	12665594	GOA
involved in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IDA IDA: Inferred from direct assay	11546874	GOA
involved in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IMP IMP: Inferred from mutant phenotype	16209946	GOA
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	12665594	GOA
involved in regulation of alternative mRNA splicing, via spliceosome	IMP IMP: Inferred from mutant phenotype	22203037	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of ASAP complex	IDA IDA: Inferred from direct assay	12665594	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	11546874	GOA
located in nucleus	IDA IDA: Inferred from direct assay	11546874	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RNPS1 Protein Structure

RRM_1

0
100
200
305 a.a.

Protein Preferred Names	Protein Names
RNA-binding protein with serine-rich domain 1	RNA binding protein with serine-rich domain

RNPS1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RNPS1	Q15287	ZNF394	Homo sapiens	Q53GI3	Y2H Array	32296183
Intra	RNPS1	Q15287	ZNF394	Homo sapiens	Q53GI3	Y2H Prey Pooling	32296183
Intra	RNPS1	Q15287	ZNF394	Homo sapiens	Q53GI3	Validated Y2H	32296183
Intra	RNPS1	Q15287	FAM81B	Homo sapiens	Q96LP2	Validated Y2H	32296183
Intra	RNPS1	Q15287	FAM81B	Homo sapiens	Q96LP2	Y2H Array	32296183
Intra	RNPS1	Q15287	FAM81B	Homo sapiens	Q96LP2	Y2H Prey Pooling	32296183
Intra	RNPS1	Q15287	PSTPIP1	Homo sapiens	O43586	Y2H Array	32296183
Intra	RNPS1	Q15287	PSTPIP1	Homo sapiens	O43586	Y2H Prey Pooling	32296183
Intra	RNPS1	Q15287	ZNF286A	Homo sapiens	Q9HBT8	Validated Y2H	32296183
Intra	RNPS1	Q15287	ZNF286A	Homo sapiens	Q9HBT8	Y2H Array	32296183
Intra	RNPS1	Q15287	ZNF286A	Homo sapiens	Q9HBT8	Y2H Prey Pooling	32296183
Intra	RNPS1	Q15287	ABI2	Homo sapiens	Q9NYB9-2	Validated Y2H	32296183
Intra	RNPS1	Q15287	ABI2	Homo sapiens	Q9NYB9-2	Y2H Prey Pooling	32296183
Intra	RNPS1	Q15287	ABI2	Homo sapiens	Q9NYB9-2	Y2H Array	32296183
Intra	RNPS1	Q15287	ZSCAN30	Homo sapiens	Q86W11	Y2H Prey Pooling	32296183
Intra	RNPS1	Q15287	ZSCAN30	Homo sapiens	Q86W11	Validated Y2H	32296183
Intra	RNPS1	Q15287	ZSCAN30	Homo sapiens	Q86W11	Y2H Array	32296183
Intra	RNPS1	Q15287	ZNF660	Homo sapiens	Q6AZW8	Y2H Prey Pooling	32296183
Intra	RNPS1	Q15287	ZNF660	Homo sapiens	Q6AZW8	Validated Y2H	32296183
Intra	RNPS1	Q15287	ZNF660	Homo sapiens	Q6AZW8	Y2H Array	32296183
Intra	RNPS1	Q15287	ZNF41	Homo sapiens	P51814-6	Y2H Prey Pooling	32296183
Intra	RNPS1	Q15287	ZNF41	Homo sapiens	P51814-6	Y2H Array	32296183
Intra	RNPS1	Q15287	TRA2A	Homo sapiens	Q13595	Anti Tag CoIP	33961781
Intra	RNPS1	Q15287	TRA2A	Homo sapiens	Q13595	Y2H Array	32296183
Intra	RNPS1	Q15287	TRA2A	Homo sapiens	Q13595	Y2H Prey Pooling	32296183
Intra	RNPS1	Q15287	ZNF345	Homo sapiens	Q14585	Y2H Array	32296183
Intra	RNPS1	Q15287	ZNF345	Homo sapiens	Q14585	Y2H Prey Pooling	32296183
Intra	RNPS1	Q15287	CCNL1	Homo sapiens	Q9UK58	Y2H Prey Pooling	32296183
Intra	RNPS1	Q15287	CCNL1	Homo sapiens	Q9UK58	Anti Tag CoIP	26496610
Intra	RNPS1	Q15287	CCNL1	Homo sapiens	Q9UK58	Validated Y2H	32296183
Intra	RNPS1	Q15287	CCNL1	Homo sapiens	Q9UK58	Y2H Array	32296183
Intra	RNPS1	Q15287	YTHDC1	Homo sapiens	Q96MU7	Y2H Prey Pooling	32296183
Intra	RNPS1	Q15287	YTHDC1	Homo sapiens	Q96MU7	Validated Y2H	32296183
Intra	RNPS1	Q15287	YTHDC1	Homo sapiens	Q96MU7	Y2H Array	32296183
Intra	RNPS1	Q15287	SRSF9	Homo sapiens	Q13242	Y2H Array	32296183
Intra	RNPS1	Q15287	SRSF9	Homo sapiens	Q13242	Y2H Prey Pooling	32296183
Intra	RNPS1	Q15287	SRSF10	Homo sapiens	O75494	Anti Tag CoIP	33961781
Intra	RNPS1	Q15287	SRSF10	Homo sapiens	O75494	Y2H Array	32296183
Intra	RNPS1	Q15287	SRSF10	Homo sapiens	O75494	Y2H Prey Pooling	32296183
Intra	RNPS1	Q15287	SRSF3	Homo sapiens	P84103	Y2H Array	32296183
Intra	RNPS1	Q15287	SRSF3	Homo sapiens	P84103	Y2H Prey Pooling	32296183
Intra	RNPS1	Q15287	SRRM4	Homo sapiens	A7MD48	Y2H Array	32296183
Intra	RNPS1	Q15287	SRRM4	Homo sapiens	A7MD48	Y2H Prey Pooling	32296183
Intra	RNPS1	Q15287	NKAPD1	Homo sapiens	Q6ZUT1	Y2H Prey Pooling	32296183
Intra	RNPS1	Q15287	NKAPD1	Homo sapiens	Q6ZUT1	Y2H Array	32296183
Intra	RNPS1	Q15287	NKAPD1	Homo sapiens	Q6ZUT1	Validated Y2H	32296183
Intra	RNPS1	Q15287	ACIN1	Homo sapiens	Q9UKV3	Anti Tag CoIP	33961781
Intra	RNPS1	Q15287	ACIN1	Homo sapiens	Q9UKV3	Y2H	22365833
Intra	RNPS1	Q15287	SRSF7	Homo sapiens	Q16629	Validated Y2H	32296183
Intra	RNPS1	Q15287	SRSF7	Homo sapiens	Q16629	Y2H Array	32296183
Intra	RNPS1	Q15287	SRSF7	Homo sapiens	Q16629	Y2H Prey Pooling	32296183
Intra	RNPS1	Q15287	ZRANB1	Homo sapiens	Q9UGI0	Y2H Prey Pooling	32296183
Intra	RNPS1	Q15287	ZRANB1	Homo sapiens	Q9UGI0	Validated Y2H	32296183
Intra	RNPS1	Q15287	ZRANB1	Homo sapiens	Q9UGI0	Y2H Array	32296183
Intra	RNPS1	Q15287	SRPK1	Homo sapiens	Q96SB4	Anti Tag CoIP	33961781
Intra	RNPS1	Q15287	SRPK1	Homo sapiens	Q96SB4	Anti Tag CoIP	23602568
Intra	RNPS1	Q15287	SRPK1	Homo sapiens	Q96SB4	Anti Bait CoIP	17353931
Intra	RNPS1	Q15287	HEXIM2	Homo sapiens	Q96MH2	Validated Y2H	32296183
Intra	RNPS1	Q15287	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Prey Pooling	32296183
Intra	RNPS1	Q15287	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Array	32296183
Intra	RNPS1	Q15287	SRPK2	Homo sapiens	P78362	Y2H Prey Pooling	32296183
Intra	RNPS1	Q15287	SRPK2	Homo sapiens	P78362	Y2H Array	32296183
Intra	RNPS1	Q15287	SRPK2	Homo sapiens	P78362	Anti Bait CoIP	17353931
Intra	RNPS1	Q15287	SRPK2	Homo sapiens	P78362	Anti Tag CoIP	33961781
Intra	RNPS1	Q15287	STX11	Homo sapiens	O75558	Y2H Prey Pooling	32296183
Intra	RNPS1	Q15287	STX11	Homo sapiens	O75558	Y2H Array	32296183
Intra	RNPS1	Q15287	ZNF165	Homo sapiens	P49910	Y2H Array	32296183
Intra	RNPS1	Q15287	ZNF165	Homo sapiens	P49910	Y2H Prey Pooling	32296183
Intra	RNPS1	Q15287	ELOA2	Homo sapiens	Q8IYF1	Y2H Prey Pooling	32296183
Intra	RNPS1	Q15287	ELOA2	Homo sapiens	Q8IYF1	Y2H Array	32296183
Intra	RNPS1	Q15287	ELOA2	Homo sapiens	Q8IYF1	Validated Y2H	32296183
Intra	RNPS1	Q15287	SDCBP2	Homo sapiens	Q9H190	Validated Y2H	32296183
Intra	RNPS1	Q15287	SDCBP2	Homo sapiens	Q9H190	Y2H Array	32296183
Intra	RNPS1	Q15287	SDCBP2	Homo sapiens	Q9H190	Y2H Prey Pooling	32296183
Intra	RNPS1	Q15287	SDCBP2	Homo sapiens	Q9H190	Y2H Array	31515488
Intra	RNPS1	Q15287	SRSF6	Homo sapiens	Q13247	Anti Tag CoIP	33961781
Intra	RNPS1	Q15287	CLK3	Homo sapiens	P49761	Y2H Prey Pooling	32296183
Intra	RNPS1	Q15287	CLK3	Homo sapiens	P49761	Validated Y2H	32296183
Intra	RNPS1	Q15287	CLK3	Homo sapiens	P49761	Y2H Array	32296183
Intra	RNPS1	Q15287	CLK2	Homo sapiens	P49760	Y2H Array	32296183
Intra	RNPS1	Q15287	CLK2	Homo sapiens	P49760	Y2H Prey Pooling	32296183
Intra	RNPS1	Q15287	PICK1	Homo sapiens	Q9NRD5	Y2H Prey Pooling	32296183
Intra	RNPS1	Q15287	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183
Intra	RNPS1	Q15287	PICK1	Homo sapiens	Q9NRD5	Y2H Array	32296183
Intra	RNPS1	Q15287	RBMY1F	Homo sapiens	Q15415	Y2H Prey Pooling	32296183
Intra	RNPS1	Q15287	RBMY1F	Homo sapiens	Q15415	Y2H Array	32296183
Intra	RNPS1	Q15287	RBMY1F	Homo sapiens	Q15415	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Metaphyseal Chondrodysplasia, Schmid Type	MCDS Schmid Metaphyseal Chondrodysplasia Metaphyseal Chondrodysplasia Schmid Type Spondylometaphyseal Dysplasia, Japanese Type Japanese Type Spondylometaphyseal Dysplasia Schmid Type Metaphyseal Dysplasia Metaphyseal Chondrodysplasia Type Schmid Schmid Type Metaphyseal Chondrodysplasia SMCD Chondrodysplasia, Metaphyseal, Schmid Type Corneal Dystrophy, Subepithelial Mucinous

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P10680	TFE-IDAtp1-LinA		/	Unkown
HY-RS12108	RNPS1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	RNPS1	RGD	RGD:1307522
Canis familiaris	RNPS1	VGNC	VGNC:45683
Mus musculus	RNPS1	MGD	MGI:97960
Felis catus	RNPS1	VGNC	VGNC:80680
Others	RNPS1	NCBI