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CLK3 - CDC like kinase 3 Gene

Also Known as PHCLK3; PHCLK3/152

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1198

About CLK3

Cytogenetic location: 15q24.1 Genomic coordinates (GRCh38): 15:74,608,372-74,630,201 (from NCBI)

This gene has 27 transcripts (splice variants), 625 orthologues and 12 paralogues. Ubiquitous expression in bone marrow (RPKM 16.0), testis (RPKM 5.8) and 25 other tissues.

Summary

This gene encodes a protein belonging to the serine/threonine type protein kinase family. This protein is a nuclear dual-specificity kinase that regulates the intranuclear distribution of the serine/arginine-rich (SR) family of splicing factors. Two transcript variants encoding different isoforms have been found for this gene. Related pseudogenes are located on chromosomes 1 and 9. [provided by RefSeq, Jul 2008]

CLK3 Products (2)

mRNA	Protein	Name
NM_001130028.2	NP_001123500.2	dual specificity protein kinase CLK3
NM_003992.5	NP_003983.2	dual specificity protein kinase CLK3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	9637771	GOA
involved in regulation of RNA splicing	IDA IDA: Inferred from direct assay	9637771	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	9637771	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CLK3 Protein Structure

Pkinase

0
100
200
300
400
500
600
638 a.a.

Protein Preferred Names	Protein Names
dual specificity protein kinase CLK3

CLK3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CLK3	P49761	OAS2	Homo sapiens	P29728	Y2H Array	25416956
Intra	CLK3	P49761	OAS2	Homo sapiens	P29728	Y2H Prey Pooling	25416956
Intra	CLK3	P49761	OAS2	Homo sapiens	P29728	Y2H Array	31515488
Intra	CLK3	P49761	HOXB7	Homo sapiens	P09629	Validated Y2H	25416956
Intra	CLK3	P49761	HOXB7	Homo sapiens	P09629	Y2H Prey Pooling	25416956
Intra	CLK3	P49761	SUV39H1	Homo sapiens	O43463	Y2H	23455924
Intra	CLK3	P49761	SUV39H1	Homo sapiens	O43463	Anti Tag CoIP	23455924
Intra	CLK3	P49761	HSP90AB1	Homo sapiens	P08238	Lumier	22939624
Intra	CLK3	P49761	HSP90AB1	Homo sapiens	P08238	Pull Down	32707033
Intra	CLK3	P49761	SRSF10	Homo sapiens	O75494	Anti Tag CoIP	33961781
Intra	CLK3	P49761	YWHAE	Homo sapiens	P62258	Crosslink	36931259
Intra	CLK3	P49761	SRSF3	Homo sapiens	P84103	Anti Tag CoIP	33961781
Intra	CLK3	P49761	RNPS1	Homo sapiens	Q15287	Anti Tag CoIP	33961781
Intra	CLK3	P49761	RNPS1	Homo sapiens	Q15287	Pull Down	32707033
Intra	CLK3	P49761	SRPK2	Homo sapiens	P78362	Anti Tag CoIP	33961781
Intra	CLK3	P49761	SRPK2	Homo sapiens	P78362	Protein Kinase Assay	23602568
Intra	CLK3	P49761	SRPK2	Homo sapiens	P78362	Pull Down	32707033
Intra	CLK3	P49761	TINF2	Homo sapiens	Q9BSI4	Pull Down	21044950
Intra	CLK3	P49761	TRA2B	Homo sapiens	P62995	Anti Tag CoIP	33961781
Intra	CLK3	P49761	TRA2B	Homo sapiens	P62995	TAP	23602568
Intra	CLK3	P49761	TRA2B	Homo sapiens	P62995	Pull Down	32707033
Intra	CLK3	P49761	SDCBP	Homo sapiens	O00560	Validated Y2H	25416956
Intra	CLK3	P49761	SDCBP	Homo sapiens	O00560	Y2H Prey Pooling	25416956
Intra	CLK3	P49761	HOXB6	Homo sapiens	P17509	Validated Y2H	25416956
Intra	CLK3	P49761	RBMX	Homo sapiens	P38159	Y2H Prey Pooling	25416956
Intra	CLK3	P49761	RBMX	Homo sapiens	P38159	Validated Y2H	25416956
Intra	CLK3	P49761	ZNF263	Homo sapiens	O14978	Validated Y2H	25416956
Intra	CLK3	P49761	CLK2	Homo sapiens	P49760	Validated Y2H	25416956
Intra	CLK3	P49761	CLK2	Homo sapiens	P49760	Y2H Array	25416956
Intra	CLK3	P49761	RSRP1	Homo sapiens	Q9BUV0	Y2H Array	25416956
Intra	CLK3	P49761	RSRP1	Homo sapiens	Q9BUV0	Validated Y2H	25416956
Intra	CLK3	P49761	RSRP1	Homo sapiens	Q9BUV0	Y2H Pooling	16189514
Intra	CLK3	P49761	CLK2	Homo sapiens	P49760	Anti Tag CoIP	33961781
Intra	CLK3	P49761	CLK2	Homo sapiens	P49760	Y2H	21516116
Intra	CLK3	P49761	CLK2	Homo sapiens	P49760	Y2H Prey Pooling	25416956
Intra	CLK3	P49761	RSRP1	Homo sapiens	Q9BUV0	Y2H Array	31515488
Intra	CLK3	P49761	CLASRP	Homo sapiens	Q8N2M8	Pull Down	32707033
Intra	CLK3	P49761	RBMY1A1	Homo sapiens	P0DJD3	Y2H Prey Pooling	25416956
Intra	CLK3	P49761	RBMY1A1	Homo sapiens	P0DJD3	Y2H Array	25416956
Intra	CLK3	P49761	RBMY1A1	Homo sapiens	P0DJD3	Validated Y2H	25416956
Intra	CLK3	P49761	RBMY1F	Homo sapiens	Q15415	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-137443	Ipivivint	Inhibitor	99.95%	Phase 1

Pre-clinical Phase

Bioactive Molecules (12)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-115470	CLK-IN-T3	Inhibitor	99.78%	Unkown
HY-112296	T025		99.64%	Unkown
HY-15951	ML167	Inhibitor	98.62%	Unkown
HY-12828	KH-CB19	Inhibitor	99.31%	Unkown
HY-103647	K00546	Inhibitor	99.48%	Unkown
HY-155723	Leucettinib-92	Inhibitor	98.54%	Unkown
HY-12828A	KH-CB20	Inhibitor	99.80%	Unkown
HY-E70692	CLK3 Recombinant Human Active Protein Kinase		/	Unkown
HY-RS02818	CLK3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-159963	PfCLK3-IN-1	Inhibitor	/	Unkown
HY-RS16964	Clk3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23407	Clk3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CLK3	VGNC	VGNC:60964
Rattus norvegicus	CLK3	RGD	RGD:621259
Mus musculus	CLK3	MGD	MGI:1098670
Canis familiaris	CLK3	VGNC	VGNC:39348
Bos taurus	CLK3	VGNC	VGNC:27450
Macaca mulatta	CLK3	VGNC	VGNC:71260
Others	CLK3	NCBI