HOXB6 - homeobox B6 Gene

Also Known as HOX2; HU-2; HOX2B; Hox-2.2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3216

About HOXB6

Cytogenetic location: 17q21.32 Genomic coordinates (GRCh38): 17:48,595,751-48,604,986 (from NCBI)

This gene has 4 transcripts (splice variants), 151 orthologues and 42 paralogues. Biased expression in kidney (RPKM 11.8), colon (RPKM 5.2) and 9 other tissues.

Summary

This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development, including that of lung and skin, and has been localized to both the nucleus and cytoplasm. Altered expression of this gene or a change in the subcellular localization of its protein is associated with some cases of acute myeloid leukemia and colorectal Cancer. [provided by RefSeq, Jul 2008]

HOXB6 Products (2)

mRNA Protein Name
NM_001369397.2 NP_001356326.1 homeobox protein Hox-B6
NM_018952.5 NP_061825.2 homeobox protein Hox-B6

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HOXB6 Protein Structure

Homeobox

Homeobox: Homeobox domain (147 - 203)

  • 0
  • 100
  • 200
  • 224 a.a.
Protein Preferred Names Protein Names

homeobox protein Hox-B6

  • homeo box 2B

HOXB6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
HOXB6 P17509 TEKT5 Homo sapiens Q96M29
Validated Y2H
32296183
Intra
HOXB6 P17509 NEK6 Homo sapiens Q9HC98-4
Validated Y2H
32296183
Intra
HOXB6 P17509 SRPK2 Homo sapiens P78362
Validated Y2H
32296183
Intra
HOXB6 P17509 NTAQ1 Homo sapiens Q96HA8
Validated Y2H
32296183
Intra
HOXB6 P17509 CLK3 Homo sapiens P49761
Y2H Prey Pooling
25416956
Intra
HOXB6 P17509 CLK3 Homo sapiens P49761
Y2H Prey Pooling
32296183
Intra
HOXB6 P17509 CLK3 Homo sapiens P49761
Validated Y2H
32296183
Intra
HOXB6 P17509 CLK3 Homo sapiens P49761
Y2H Array
25416956
Intra
HOXB6 P17509 CLK3 Homo sapiens P49761
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Hypospadias

  • Hypospadias Familial

  • Familial Hypospadias
Hand-Foot-Genital Syndrome

  • Hand-Foot-Uterus Syndrome

  • Hfgs

  • Hfg Syndrome

  • Hfu Syndrome

  • HFG

  • Hfu

  • Hand Foot Uterus Syndrome

  • Hand Foot Genital Syndrome
Barrett Esophagus

  • Barrett'S Esophagus

  • Barrett Esophagus/Esophageal Adenocarcinoma

  • Barrett Metaplasia

  • Barrett'S Ulcer Of Esophagus

  • Ulcerative Esophagitis

  • Barrett'S Esophagus With Esophagitis

  • Barrett'S Oesophagus

  • Barretts Syndrome

  • Barrett Syndrome

  • BE

  • Peptic Ulcer Of Esophagus

  • Adenocarcinoma Of Esophagus
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06310 HOXB6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22560 Hoxb6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29080 Hoxb6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus HOXB6 RGD RGD:1562142
Bos taurus HOXB6 VGNC VGNC:106770
Macaca mulatta HOXB6 VGNC VGNC:104620
Mus musculus HOXB6 MGD MGI:96187
Canis familiaris HOXB6 VGNC VGNC:41752
Felis catus HOXB6 VGNC VGNC:99081
Others HOXB6 NCBI