HOXB6 - homeobox B6 Gene

Homo sapiens

Also known as HOX2; HU-2; HOX2B; Hox-2.2

Gene ID: 3216 | Gene type: protein coding

About HOXB6

Cytogenetic location: 17q21.32 Genomic coordinates (GRCh38): 17:48,595,751-48,604,986 (from NCBI)

This gene has 4 transcripts (splice variants), 151 orthologues and 42 paralogues. Biased expression in kidney (RPKM 11.8), colon (RPKM 5.2) and 9 other tissues.

Summary

This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development, including that of lung and skin, and has been localized to both the nucleus and cytoplasm. Altered expression of this gene or a change in the subcellular localization of its protein is associated with some cases of acute myeloid leukemia and colorectal Cancer. [provided by RefSeq, Jul 2008]

HOXB6 Products(2)

mRNA	Protein	Name
NM_001369397.2	NP_001356326.1	homeobox protein Hox-B6
NM_018952.5	NP_061825.2	homeobox protein Hox-B6

HOXB6 Protein Structure

Homeobox

0
100
200
224 a.a.

Protein Preferred Names

Protein Names

homeobox protein Hox-B6

homeo box 2B

Related Diseases

Diseases

Alias

Hypospadias

Hypospadias Familial

Familial Hypospadias

Hand-Foot-Genital Syndrome

Hand-Foot-Uterus Syndrome	Hfgs
Hfg Syndrome	Hfu Syndrome
HFG	Hfu
Hand Foot Uterus Syndrome	Hand Foot Genital Syndrome

Barrett Esophagus

Barrett'S Esophagus	Barrett Esophagus/Esophageal Adenocarcinoma
Barrett Metaplasia	Barrett'S Ulcer Of Esophagus
Ulcerative Esophagitis	Barrett'S Esophagus With Esophagitis
Barrett'S Oesophagus	Barretts Syndrome
Barrett Syndrome	BE
Peptic Ulcer Of Esophagus	Adenocarcinoma Of Esophagus

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06310	HOXB6 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	HOXB6	RGD	RGD:1562142
Bos taurus	HOXB6	VGNC	VGNC:106770
Macaca mulatta	HOXB6	VGNC	VGNC:104620
Mus musculus	HOXB6	MGD	MGI:96187
Canis familiaris	HOXB6	VGNC	VGNC:41752
Felis catus	HOXB6	VGNC	VGNC:99081

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