SRPK2 - SRSF protein kinase 2 Gene

Also Known as SFRSK2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6733

About SRPK2

Cytogenetic location: 7q22.3 Genomic coordinates (GRCh38): 7:105,114,740-105,399,357 (from NCBI)

This gene has 15 transcripts (splice variants), 236 orthologues and 19 paralogues. Broad expression in testis (RPKM 31.3), brain (RPKM 21.9) and 24 other tissues.

Summary

Enables ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in several processes, including nucleic acid metabolic process; peptidyl-serine phosphorylation; and regulation of viral genome replication. Located in chromatin; cytosol; and nuclear lumen. [provided by Alliance of Genome Resources, Apr 2022]

SRPK2 Products (12)

mRNA Protein Name
NM_001278273.2 NP_001265202.1 SRSF protein kinase 2 isoform b precursor
NM_001350738.2 NP_001337667.1 SRSF protein kinase 2 isoform b
NM_001350739.2 NP_001337668.1 SRSF protein kinase 2 isoform c
NM_001350740.2 NP_001337669.1 SRSF protein kinase 2 isoform d
NM_001350741.2 NP_001337670.1 SRSF protein kinase 2 isoform e
NM_001350742.2 NP_001337671.1 SRSF protein kinase 2 isoform f
NM_001350743.2 NP_001337672.1 SRSF protein kinase 2 isoform g
NM_001350744.2 NP_001337673.1 SRSF protein kinase 2 isoform g
NM_001350745.2 NP_001337674.1 SRSF protein kinase 2 isoform h
NM_001350746.2 NP_001337675.1 SRSF protein kinase 2 isoform i
NM_182691.3 NP_872633.1 SRSF protein kinase 2 isoform b precursor
NM_182692.3 NP_872634.1 SRSF protein kinase 2 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATP binding IDA
IDA: Inferred from direct assay
9472028 GOA
enables magnesium ion binding IDA
IDA: Inferred from direct assay
9472028 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
9472028 GOA
enables protein serine/threonine kinase activity IGI
IGI: Inferred from genetic interaction
26167880 GOA
Biological Process GO Annotation Evidence References Source
involved in R-loop processing IDA
IDA: Inferred from direct assay
28076779 GOA
involved in RNA splicing IDA
IDA: Inferred from direct assay
9472028 GOA
involved in intracellular signal transduction IDA
IDA: Inferred from direct assay
9472028 GOA
involved in negative regulation of viral genome replication IDA
IDA: Inferred from direct assay
12417631 GOA
involved in peptidyl-serine phosphorylation IGI
IGI: Inferred from genetic interaction
26167880 GOA
involved in positive regulation of cell population proliferation IDA
IDA: Inferred from direct assay
18559500 GOA
involved in positive regulation of viral genome replication IDA
IDA: Inferred from direct assay
20498328 GOA
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
9472028 GOA
involved in spliceosomal complex assembly IDA
IDA: Inferred from direct assay
9472028 GOA
Cellular Component GO Annotation Evidence References Source
located in chromatin IDA
IDA: Inferred from direct assay
28076779 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
9472028 GOA
located in nuclear speck IDA
IDA: Inferred from direct assay
28076779 GOA
located in nucleoplasm IDA
IDA: Inferred from direct assay
28076779 GOA
located in nucleus IDA
IDA: Inferred from direct assay
9472028 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SRPK2 Protein Structure

Pkinase

Pkinase: Protein kinase domain (81 - 223)

Pkinase

Pkinase: Protein kinase domain (524 - 686)

  • 0
  • 200
  • 400
  • 600
  • 688 a.a.
Protein Preferred Names Protein Names

SRSF protein kinase 2

  • SFRS protein kinase 2

SRPK2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SRPK2 P78362 rnps1 Homo sapiens D3DU92
Validated Y2H
25416956
Intra
SRPK2 P78362 rnps1 Homo sapiens D3DU92
Y2H Prey Pooling
25416956
Intra
SRPK2 P78362 U2AF1 Homo sapiens Q01081-2
Validated Y2H
25416956
Intra
SRPK2 P78362 LUZP4 Homo sapiens Q9P127
Validated Y2H
25416956
Intra
SRPK2 P78362 RIMS1 Homo sapiens Q86UR5
Anti Bait CoIP
37207277
Intra
SRPK2 P78362 SREK1 Homo sapiens Q8WXA9
Pull Down
32707033
Intra
SRPK2 P78362 SREK1 Homo sapiens Q8WXA9
Anti Tag CoIP
33961781
Intra
SRPK2 P78362 SNRNP70 Homo sapiens P08621
Y2H
22365833
Intra
SRPK2 P78362 SNRNP70 Homo sapiens P08621
Pull Down
32707033
Intra
SRPK2 P78362 SNRNP70 Homo sapiens P08621
Protein Kinase Assay
23602568
Intra
SRPK2 P78362 SNRNP70 Homo sapiens P08621
TAP
23602568
Intra
SRPK2 P78362 SRRM1 Homo sapiens Q8IYB3
Pull Down
32707033
Intra
SRPK2 P78362 SRRM1 Homo sapiens Q8IYB3
BiFC
23602568
Intra
SRPK2 P78362 SRRM1 Homo sapiens Q8IYB3
Anti Tag CoIP
33961781
Intra
SRPK2 P78362 SRRM1 Homo sapiens Q8IYB3
TAP
23602568
Intra
SRPK2 P78362 SRSF8 Homo sapiens Q9BRL6-2
Validated Y2H
32296183
Intra
SRPK2 P78362 FXR1 Homo sapiens P51114-2
Y2H Prey Pooling
32296183
Intra
SRPK2 P78362 FXR1 Homo sapiens P51114-2
Y2H Array
32296183
Intra
SRPK2 P78362 U2AF2 Homo sapiens P26368-2
Y2H Array
32296183
Intra
SRPK2 P78362 U2AF2 Homo sapiens P26368-2
Y2H Prey Pooling
32296183
Intra
SRPK2 P78362 HCN1 Homo sapiens O60741
Anti Bait CoIP
37207277
Intra
SRPK2 P78362 SRSF11 Homo sapiens Q05519-2
Validated Y2H
32296183
Intra
SRPK2 P78362 SRSF11 Homo sapiens Q05519-2
Y2H Array
32296183
Intra
SRPK2 P78362 SRSF11 Homo sapiens Q05519-2
Y2H Prey Pooling
32296183
Intra
SRPK2 P78362 ZSCAN12 Homo sapiens O43309
Y2H Prey Pooling
32296183
Intra
SRPK2 P78362 ZSCAN12 Homo sapiens O43309
Y2H Array
32296183
Intra
SRPK2 P78362 PRR20D Homo sapiens P86480
Y2H Prey Pooling
32296183
Intra
SRPK2 P78362 PRR20D Homo sapiens P86480
Y2H Array
32296183
Intra
SRPK2 P78362 PRR20D Homo sapiens P86480
Validated Y2H
32296183
Intra
SRPK2 P78362 SNRNP27 Homo sapiens Q8WVK2
Y2H
22365833
Intra
SRPK2 P78362 DDX46 Homo sapiens Q7L014
Pull Down
32707033
Intra
SRPK2 P78362 DDX46 Homo sapiens Q7L014
TAP
23602568
Intra
SRPK2 P78362 DDX46 Homo sapiens Q7L014
Anti Tag CoIP
33961781
Intra
SRPK2 P78362 ARL6IP4 Homo sapiens Q66PJ3
Pull Down
32707033
Intra
SRPK2 P78362 ARL6IP4 Homo sapiens Q66PJ3
Protein Kinase Assay
23602568
Intra
SRPK2 P78362 TRA2A Homo sapiens Q13595
Protein Kinase Assay
23602568
Intra
SRPK2 P78362 TRA2A Homo sapiens Q13595
Pull Down
32707033
Intra
SRPK2 P78362 NOM1 Homo sapiens Q5C9Z4
Y2H Array
32296183
Intra
SRPK2 P78362 NOM1 Homo sapiens Q5C9Z4
Y2H Prey Pooling
32296183
Intra
SRPK2 P78362 NOM1 Homo sapiens Q5C9Z4
Validated Y2H
32296183
Intra
SRPK2 P78362 ARGLU1 Homo sapiens Q9NWB6
Y2H
22365833
Intra
SRPK2 P78362 ARGLU1 Homo sapiens Q9NWB6
Anti Tag CoIP
33961781
Intra
SRPK2 P78362 YTHDC1 Homo sapiens Q96MU7
Anti Tag CoIP
33961781
Intra
SRPK2 P78362 YTHDC1 Homo sapiens Q96MU7
TAP
23602568
Intra
SRPK2 P78362 YTHDC1 Homo sapiens Q96MU7
BiFC
23602568
Intra
SRPK2 P78362 YTHDC1 Homo sapiens Q96MU7
Pull Down
32707033
Intra
SRPK2 P78362 CHTOP Homo sapiens Q9Y3Y2
Protein Kinase Assay
23602568
Intra
SRPK2 P78362 CHTOP Homo sapiens Q9Y3Y2
Pull Down
32707033
Intra
SRPK2 P78362 LUC7L2 Homo sapiens Q9Y383
Pull Down
32707033
Intra
SRPK2 P78362 LUC7L2 Homo sapiens Q9Y383
TAP
23602568
Intra
SRPK2 P78362 SRSF10 Homo sapiens O75494
Pull Down
32707033
Intra
SRPK2 P78362 SRSF10 Homo sapiens O75494
Anti Tag CoIP
33961781
Intra
SRPK2 P78362 DDX21 Homo sapiens Q9NR30
TAP
23602568
Intra
SRPK2 P78362 HNRNPC Homo sapiens P07910
TAP
23602568
Intra
SRPK2 P78362 RBM39 Homo sapiens Q14498
Anti Tag CoIP
33961781
Intra
SRPK2 P78362 RBM39 Homo sapiens Q14498
Validated Y2H
25416956
Intra
SRPK2 P78362 RBM39 Homo sapiens Q14498
Protein Kinase Assay
23602568
Intra
SRPK2 P78362 RBM39 Homo sapiens Q14498
Pull Down
32707033
Intra
SRPK2 P78362 RBM39 Homo sapiens Q14498
Y2H Prey Pooling
25416956
Intra
SRPK2 P78362 RBM39 Homo sapiens Q14498
Y2H Array
25416956
Intra
SRPK2 P78362 RBM39 Homo sapiens Q14498
TAP
23602568
Intra
SRPK2 P78362 RNPS1 Homo sapiens Q15287
Y2H
22365833
Intra
SRPK2 P78362 RNPS1 Homo sapiens Q15287
Validated Y2H
32296183
Intra
SRPK2 P78362 RNPS1 Homo sapiens Q15287
Pull Down
32707033
Intra
SRPK2 P78362 TCOF1 Homo sapiens Q13428
Pull Down
32707033
Intra
SRPK2 P78362 ACIN1 Homo sapiens Q9UKV3
Anti Tag CoIP
33961781
Intra
SRPK2 P78362 ACIN1 Homo sapiens Q9UKV3
TAP
23602568
Intra
SRPK2 P78362 ACIN1 Homo sapiens Q9UKV3
Y2H
22365833
Intra
SRPK2 P78362 SRSF7 Homo sapiens Q16629
Protein Kinase Assay
23602568
Intra
SRPK2 P78362 SRSF7 Homo sapiens Q16629
TAP
23602568
Intra
SRPK2 P78362 RBM8A Homo sapiens Q9Y5S9
TAP
23602568
Intra
SRPK2 P78362 LUC7L Homo sapiens Q9NQ29
Protein Kinase Assay
23602568
Intra
SRPK2 P78362 LUC7L Homo sapiens Q9NQ29
Pull Down
32707033
Intra
SRPK2 P78362 LUC7L Homo sapiens Q9NQ29
TAP
23602568
Intra
SRPK2 P78362 SRSF12 Homo sapiens Q8WXF0
Anti Tag CoIP
33961781
Intra
SRPK2 P78362 SRSF12 Homo sapiens Q8WXF0
Protein Kinase Assay
23602568
Intra
SRPK2 P78362 NSRP1 Homo sapiens Q9H0G5
Anti Tag CoIP
35271311
Intra
SRPK2 P78362 NSRP1 Homo sapiens Q9H0G5
Protein Kinase Assay
23602568
Intra
SRPK2 P78362 U2AF1 Homo sapiens Q01081
Anti Tag CoIP
23602568
Intra
SRPK2 P78362 U2AF1 Homo sapiens Q01081
TAP
23602568
Intra
SRPK2 P78362 U2AF1 Homo sapiens Q01081
Y2H
22365833
Intra
SRPK2 P78362 U2AF1 Homo sapiens Q01081
Y2H Array
25416956
Intra
SRPK2 P78362 SRSF8 Homo sapiens Q9BRL6
Anti Tag CoIP
33961781
Intra
SRPK2 P78362 SRSF8 Homo sapiens Q9BRL6
Protein Kinase Assay
23602568
Intra
SRPK2 P78362 SRSF8 Homo sapiens Q9BRL6
TAP
23602568
Intra
SRPK2 P78362 ZRSR2 Homo sapiens Q15696
Validated Y2H
32296183
Intra
SRPK2 P78362 ZRSR2 Homo sapiens Q15696
Y2H Array
25416956
Intra
SRPK2 P78362 ZRSR2 Homo sapiens Q15696
Validated Y2H
25416956
Intra
SRPK2 P78362 RSRC1 Homo sapiens Q96IZ7
Anti Tag CoIP
33961781
Intra
SRPK2 P78362 PRPF38A Homo sapiens Q8NAV1
Anti Tag CoIP
33961781
Intra
SRPK2 P78362 PRPF38A Homo sapiens Q8NAV1
Y2H Array
25416956
Intra
SRPK2 P78362 PRPF38A Homo sapiens Q8NAV1
Pull Down
32707033
Intra
SRPK2 P78362 PRPF38A Homo sapiens Q8NAV1
Y2H
22365833
Intra
SRPK2 P78362 PRPF38A Homo sapiens Q8NAV1
Protein Kinase Assay
23602568
Intra
SRPK2 P78362 TLE5 Homo sapiens Q08117
Validated Y2H
25416956
Intra
SRPK2 P78362 TLE5 Homo sapiens Q08117
Y2H Array
25416956
Intra
SRPK2 P78362 TLE5 Homo sapiens Q08117
Y2H Prey Pooling
25416956
Intra
SRPK2 P78362 SRSF5 Homo sapiens Q13243
Pull Down
32707033
Intra
SRPK2 P78362 TRA2B Homo sapiens P62995
Protein Kinase Assay
23602568
Intra
SRPK2 P78362 TRA2B Homo sapiens P62995
Y2H Array
32296183
Intra
SRPK2 P78362 TRA2B Homo sapiens P62995
Pull Down
32707033
Intra
SRPK2 P78362 TRA2B Homo sapiens P62995
Y2H Prey Pooling
32296183
Intra
SRPK2 P78362 FXR2 Homo sapiens P51116
Y2H Array
25416956
Intra
SRPK2 P78362 FXR2 Homo sapiens P51116
Pull Down
32707033
Intra
SRPK2 P78362 HOXB6 Homo sapiens P17509
Y2H Array
32296183
Intra
SRPK2 P78362 HOXB6 Homo sapiens P17509
Y2H Prey Pooling
32296183
Intra
SRPK2 P78362 U2AF2 Homo sapiens P26368
TAP
23602568
Intra
SRPK2 P78362 U2AF2 Homo sapiens P26368
BiFC
23602568
Intra
SRPK2 P78362 U2AF2 Homo sapiens P26368
Pull Down
32707033
Intra
SRPK2 P78362 U2AF2 Homo sapiens P26368
Y2H Pooling
16189514
Intra
SRPK2 P78362 U2AF2 Homo sapiens P26368
Anti Tag CoIP
23602568
Intra
SRPK2 P78362 MMTAG2 Homo sapiens Q9BU76
TAP
23602568
Intra
SRPK2 P78362 MMTAG2 Homo sapiens Q9BU76
Pull Down
32707033
Intra
SRPK2 P78362 MMTAG2 Homo sapiens Q9BU76
Protein Kinase Assay
23602568
Intra
SRPK2 P78362 CLK3 Homo sapiens P49761
Y2H Array
25416956
Intra
SRPK2 P78362 CLK3 Homo sapiens P49761
Anti Tag CoIP
33961781
Intra
SRPK2 P78362 CLK3 Homo sapiens P49761
Y2H Prey Pooling
25416956
Intra
SRPK2 P78362 CLK3 Homo sapiens P49761
Validated Y2H
25416956
Intra
SRPK2 P78362 SNIP1 Homo sapiens Q8TAD8
Validated Y2H
32296183
Intra
SRPK2 P78362 SNIP1 Homo sapiens Q8TAD8
Y2H Array
32296183
Intra
SRPK2 P78362 SNIP1 Homo sapiens Q8TAD8
Y2H Prey Pooling
32296183
Intra
SRPK2 P78362 SNIP1 Homo sapiens Q8TAD8
Y2H
22365833
Intra
SRPK2 P78362 CLK2 Homo sapiens P49760
Validated Y2H
25416956
Intra
SRPK2 P78362 ZSCAN9 Homo sapiens O15535
Y2H Array
32296183
Intra
SRPK2 P78362 ZSCAN9 Homo sapiens O15535
Y2H Prey Pooling
25416956
Intra
SRPK2 P78362 ZSCAN9 Homo sapiens O15535
Y2H Prey Pooling
32296183
Intra
SRPK2 P78362 RBM23 Homo sapiens Q86U06
Protein Kinase Assay
23602568
Intra
SRPK2 P78362 COIL Homo sapiens P38432
Y2H Prey Pooling
32296183
Intra
SRPK2 P78362 COIL Homo sapiens P38432
Y2H Array
32296183
Intra
SRPK2 P78362 RSRC2 Homo sapiens Q7L4I2
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-148518 MSC-1186 Inhibitor 98.95% Unkown
HY-113831 CLK1/2-IN-3 Inhibitor / Unkown
HY-E70805 Biotin-SRPK2 Recombinant Human Active Protein Kinase / Unkown
HY-RS13778 SRPK2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18547 Srpk2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25029 Srpk2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SRPK2 MGD MGI:1201408
Felis catus SRPK2 VGNC VGNC:65688
Bos taurus SRPK2 VGNC VGNC:35289
Canis familiaris SRPK2 VGNC VGNC:46811
Rattus norvegicus SRPK2 RGD RGD:1305107
Macaca mulatta SRPK2 VGNC VGNC:81764
Others SRPK2 NCBI