HNRNPC - heterogeneous nuclear ribonucleoprotein C Gene

Also Known as C1; C2; HNRNP; HNRPC; SNRPC

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3183

About HNRNPC

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:21,209,147-21,269,442 (from NCBI)

This gene has 32 transcripts (splice variants), 97 orthologues and 6 paralogues. Ubiquitous expression in lymph node (RPKM 82.0), bone marrow (RPKM 78.3) and 25 other tissues.

Summary

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and Other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene can act as a tetramer and is involved in the assembly of 40S hnRNP particles. Multiple transcript variants encoding at least two different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

HNRNPC Products (4)

mRNA	Protein	Name
NM_001077442.2	NP_001070910.1	heterogeneous nuclear ribonucleoproteins C1/C2 isoform a
NM_001077443.2	NP_001070911.1	heterogeneous nuclear ribonucleoproteins C1/C2 isoform b
NM_004500.4	NP_004491.2	heterogeneous nuclear ribonucleoproteins C1/C2 isoform b
NM_031314.3	NP_112604.2	heterogeneous nuclear ribonucleoproteins C1/C2 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables N6-methyladenosine-containing RNA reader activity	IDA IDA: Inferred from direct assay	25719671	GOA
enables RNA binding	IPI IPI: Inferred from physical interaction	18082603	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables mRNA 3'-UTR binding	IDA IDA: Inferred from direct assay	16010978	GOA
enables poly(U) RNA binding	IDA IDA: Inferred from direct assay	16010978	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11546873	GOA
enables telomerase RNA binding	IPI IPI: Inferred from physical interaction	18082603	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in 3'-UTR-mediated mRNA stabilization	IMP IMP: Inferred from mutant phenotype	16010978	GOA
involved in mRNA splicing, via spliceosome	IMP IMP: Inferred from mutant phenotype	25719671	GOA
involved in negative regulation of telomere maintenance via telomerase	IMP IMP: Inferred from mutant phenotype	18082603	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in actin cytoskeleton	IDA IDA: Inferred from direct assay	11687588	GOA
part of catalytic step 2 spliceosome	IDA IDA: Inferred from direct assay	11991638	GOA
located in cytosol	IDA IDA: Inferred from direct assay	16010978	GOA
located in nucleus	IDA IDA: Inferred from direct assay	11687588	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	11687588	GOA
part of spliceosomal complex	IDA IDA: Inferred from direct assay	9731529	GOA
part of telomerase holoenzyme complex	IDA IDA: Inferred from direct assay	18082603	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HNRNPC Protein Structure

RRM_1

0
100
200
306 a.a.

Protein Preferred Names	Protein Names
heterogeneous nuclear ribonucleoproteins C1/C2	heterogeneous nuclear ribonucleoprotein C (C1/C2)

HNRNPC Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	HNRNPC	P07910	SUMO1P1	Homo sapiens	G2XKQ0	Y2H Prey Pooling	25416956
Intra	HNRNPC	P07910	SUMO1P1	Homo sapiens	G2XKQ0	Validated Y2H	25416956
Intra	HNRNPC	P07910	UBE2I	Homo sapiens	Q7KZS0	Y2H Prey Pooling	25416956
Intra	HNRNPC	P07910	HNRNPCL1	Homo sapiens	O60812	Anti Tag CoIP	33961781
Intra	HNRNPC	P07910	HNRNPCL1	Homo sapiens	O60812	Y2H Prey Pooling	32296183
Intra	HNRNPC	P07910	HNRNPCL1	Homo sapiens	O60812	Y2H Array	32296183
Intra	HNRNPC	P07910	RALYL	Homo sapiens	Q86SE5-3	Validated Y2H	32296183
Intra	HNRNPC	P07910	RALYL	Homo sapiens	Q86SE5-3	Y2H Array	32296183
Intra	HNRNPC	P07910	RALYL	Homo sapiens	Q86SE5-3	Y2H Prey Pooling	32296183
Intra	HNRNPC	P07910	RBPMS2	Homo sapiens	Q6ZRY4	Validated Y2H	32296183
Intra	HNRNPC	P07910	RBPMS2	Homo sapiens	Q6ZRY4	Y2H Array	32296183
Intra	HNRNPC	P07910	RBPMS2	Homo sapiens	Q6ZRY4	Y2H Prey Pooling	32296183
Intra	HNRNPC	P07910	DISC1	Homo sapiens	Q9NRI5-2	Y2H Prey Pooling	32296183
Intra	HNRNPC	P07910	DISC1	Homo sapiens	Q9NRI5-2	Validated Y2H	32296183
Intra	HNRNPC	P07910	DISC1	Homo sapiens	Q9NRI5-2	Y2H Array	32296183
Intra	HNRNPC	P07910	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	HNRNPC	P07910	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	HNRNPC	P07910	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
Intra	HNRNPC	P07910	SHANK3	Homo sapiens	Q9BYB0	Anti Tag CoIP	21653829
Intra	HNRNPC	P07910	SHANK3	Homo sapiens	Q9BYB0	Y2H Pooling	21653829
Intra	HNRNPC	P07910	RNF4	Homo sapiens	P78317	Y2H Prey Pooling	32296183
Intra	HNRNPC	P07910	RNF4	Homo sapiens	P78317	Validated Y2H	32296183
Intra	HNRNPC	P07910	RNF4	Homo sapiens	P78317	Y2H Array	32296183
Intra	HNRNPC	P07910	HNRNPA2B1	Homo sapiens	P22626	Crosslink	30021884
Intra	HNRNPC	P07910	HNRNPA2B1	Homo sapiens	P22626	Anti Tag CoIP	35271311
Intra	HNRNPC	P07910	HNRNPD	Homo sapiens	Q14103	Anti Tag CoIP	35271311
Intra	HNRNPC	P07910	YWHAZ	Homo sapiens	P63104	Pull Down	15161933
Intra	HNRNPC	P07910	KPNA2	Homo sapiens	P52292	Y2H Array	25416956
Intra	HNRNPC	P07910	HNRNPA1	Homo sapiens	P09651	Anti Tag CoIP	35271311
Intra	HNRNPC	P07910	HNRNPA1	Homo sapiens	P09651	Crosslink	30021884
Intra	HNRNPC	P07910	HNRNPA1	Homo sapiens	P09651	Anti Bait CoIP	11546873
Intra	HNRNPC	P07910	HNRNPC	Homo sapiens	P07910	Y2H Pooling	16189514
Intra	HNRNPC	P07910	HNRNPC	Homo sapiens	P07910	Validated Y2H	32296183
Intra	HNRNPC	P07910	HNRNPC	Homo sapiens	P07910	Y2H Array	25416956
Intra	HNRNPC	P07910	KPNA4	Homo sapiens	O00629	Anti Tag CoIP	35271311
Intra	HNRNPC	P07910	KPNA4	Homo sapiens	O00629	Y2H Array	32296183
Intra	HNRNPC	P07910	KPNA4	Homo sapiens	O00629	FPS	35044719
Intra	HNRNPC	P07910	KPNA3	Homo sapiens	O00505	Y2H Prey Pooling	25416956
Intra	HNRNPC	P07910	HNRNPC	Homo sapiens	P07910	Pull Down	16189514
Intra	HNRNPC	P07910	HNRNPC	Homo sapiens	P07910	Y2H Array	32296183
Intra	HNRNPC	P07910	KPNA3	Homo sapiens	O00505	Anti Tag CoIP	35271311
Intra	HNRNPC	P07910	HNRNPC	Homo sapiens	P07910	Y2H	22365833
Intra	HNRNPC	P07910	HNRNPC	Homo sapiens	P07910	Y2H Prey Pooling	32296183
Intra	HNRNPC	P07910	KPNA4	Homo sapiens	O00629	Validated Y2H	25416956
Intra	HNRNPC	P07910	KPNA4	Homo sapiens	O00629	Y2H Prey Pooling	32296183
Intra	HNRNPC	P07910	KPNA3	Homo sapiens	O00505	Y2H Pooling	16189514
Intra	HNRNPC	P07910	KPNA3	Homo sapiens	O00505	Y2H Pooling	19447967
Intra	HNRNPC	P07910	HNRNPC	Homo sapiens	P07910	Y2H	21516116
Intra	HNRNPC	P07910	TARDBP	Homo sapiens	Q13148	Y2H Pooling	32814053
Intra	HNRNPC	P07910	TARDBP	Homo sapiens	Q13148	Validated Y2H	32814053
Intra	HNRNPC	P07910	TARDBP	Homo sapiens	Q13148	Y2H Array	32814053
Intra	HNRNPC	P07910	CDC5L	Homo sapiens	Q99459	Anti Tag CoIP	33961781
Intra	HNRNPC	P07910	EPS8	Homo sapiens	Q12929	Y2H Prey Pooling	25416956
Intra	HNRNPC	P07910	HTT	Homo sapiens	P42858	Y2H Array	32814053
Intra	HNRNPC	P07910	HTT	Homo sapiens	P42858	Pull Down	17500595
Intra	HNRNPC	P07910	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
Intra	HNRNPC	P07910	HTT	Homo sapiens	P42858	Validated Y2H	32814053
Intra	HNRNPC	P07910	KPNA5	Homo sapiens	O15131	Y2H Array	32296183
Intra	HNRNPC	P07910	KPNA5	Homo sapiens	O15131	Y2H Prey Pooling	32296183
Intra	HNRNPC	P07910	SRPK2	Homo sapiens	P78362	Protein Kinase Assay	23602568
Intra	HNRNPC	P07910	RALY	Homo sapiens	Q9UKM9	Anti Tag CoIP	33961781
Intra	HNRNPC	P07910	SDCBP	Homo sapiens	O00560	Y2H Array	32296183
Intra	HNRNPC	P07910	SDCBP	Homo sapiens	O00560	Y2H Prey Pooling	25416956
Intra	HNRNPC	P07910	SDCBP	Homo sapiens	O00560	Y2H Prey Pooling	32296183
Intra	HNRNPC	P07910	LMO2	Homo sapiens	P25791	Y2H Array	25416956
Intra	HNRNPC	P07910	RBM41	Homo sapiens	Q96IZ5	Y2H Pooling	16189514
Intra	HNRNPC	P07910	RBM41	Homo sapiens	Q96IZ5	Y2H Array	25416956
Intra	HNRNPC	P07910	RBM41	Homo sapiens	Q96IZ5	Y2H	21516116
Intra	HNRNPC	P07910	RALYL	Homo sapiens	Q86SE5	Validated Y2H	25416956
Intra	HNRNPC	P07910	RALYL	Homo sapiens	Q86SE5	Y2H Pooling	19447967
Intra	HNRNPC	P07910	RALYL	Homo sapiens	Q86SE5	Y2H Prey Pooling	25416956
Intra	HNRNPC	P07910	RALYL	Homo sapiens	Q86SE5	Y2H Array	25416956
Intra	HNRNPC	P07910	RALYL	Homo sapiens	Q86SE5	Y2H Pooling	16189514
Intra	HNRNPC	P07910	PAX6	Homo sapiens	P26367	Y2H Prey Pooling	32296183
Intra	HNRNPC	P07910	PAX6	Homo sapiens	P26367	Validated Y2H	32296183
Intra	HNRNPC	P07910	PAX6	Homo sapiens	P26367	Y2H Array	32296183
Intra	HNRNPC	P07910	SUMO1	Homo sapiens	P63165	Validated Y2H	25416956
Intra	HNRNPC	P07910	SUMO1	Homo sapiens	P63165	Y2H Prey Pooling	32296183
Intra	HNRNPC	P07910	SUMO1	Homo sapiens	P63165	Validated Y2H	32296183
Intra	HNRNPC	P07910	SUMO1	Homo sapiens	P63165	Y2H Array	32296183
Intra	HNRNPC	P07910	ZFYVE26	Homo sapiens	Q68DK2-5	Y2H Array	25416956
Intra	HNRNPC	P07910	ZFYVE26	Homo sapiens	Q68DK2-5	Validated Y2H	25416956
Intra	HNRNPC	P07910	HNRNPCL2	Homo sapiens	B2RXH8	Y2H Array	32296183
Intra	HNRNPC	P07910	HNRNPCL2	Homo sapiens	B2RXH8	Y2H Prey Pooling	32296183
Intra	HNRNPC	P07910	RALY	Homo sapiens	Q53GL6	Validated Y2H	32296183
Intra	HNRNPC	P07910	RALY	Homo sapiens	Q53GL6	Y2H Array	32296183
Intra	HNRNPC	P07910	RALY	Homo sapiens	Q53GL6	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

HNRNPC Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82129	hnRNP C1/C2 Antibody (YA1874)	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat
HY-P85884	hnRNP C1/C2 Antibody (YA5576)	WB, ICC/IF, ELISA	Human, Mouse, Rat, Monkey, Rabbit, Orangutan

Related Diseases

Diseases	Alias
Mixed Connective Tissue Disease	Sharp Syndrome Mctd Connective Tissue Disease Overlap Syndrome Mixed Collagen Vascular Disease Mctd - [Mixed Connective Tissue Disease]
Oculopharyngeal Muscular Dystrophy	OPMD Muscular Dystrophy, Oculopharyngeal Dystrophy, Oculopharyngeal Muscular Oculopharyngeal Dystrophy Progressive Muscular Dystrophy, Oculopharyngeal Type Muscular Dystrophy Oculopharyngeal Dystrophy, Muscular, Oculopharyngeal
Connective Tissue Disease	Connective Tissue Diseases Connective Tissue Disorder Abnormality Of Connective Tissue Disorder Of Connective Tissue Connective Tissue Disorders
Multisystem Proteinopathy
Muscular Atrophy	Muscle Wasting Amyotrophia Wasting - Muscle Skeletal Muscle Atrophy
Fragile X-Associated Tremor/Ataxia Syndrome	Fxtas Syndrome Fragile X Tremor/Ataxia Syndrome Fxtas
Muscular Dystrophy	Muscular Dystrophies Congenital Md Congenital Muscular Dystrophy Cmd Mdc Dystrophy, Muscular Gower'S Muscular Dystrophy Progressive Musclular Dystrophy Pseudohypertrophic Atrophy Pseudohypertrophic Muscle Paralysis Pseudohypertrophic Muscular Atrophy Pseudohypertrophic Muscular Dystrophy Pseudohypertrophic Paralysis Pseudomuscular Hypertrophy
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 1	FTDALS1 Frontotemporal Dementia And/Or Motor Neuron Disease Ftdmnd Amyotrophic Lateral Sclerosis And/Or Frontotemporal Dementia Alsftd Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis-1 Frontotemporal Dementia With Motor Neuron Disease Ftdals Ftd-Als Ftd-Mnd Frontotemporal Dementia With Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis With Frontotemporal Dementia 1 Amyotrophic Lateral Sclerosis/Frontotemporal Dementia Dementia, Frontotemporal, And/Or Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis And/Or Frontotemporal Dementia 1 Frontotemporal Lobar Degeneration Grn-Related Frontotemporal Dementia
Frontotemporal Dementia	Pallidopontonigral Degeneration Frontotemporal Lobar Degeneration Semantic Dementia FTD Frontotemporal Lobe Dementia Multiple System Tauopathy With Presenile Dementia Dementia, Frontotemporal Frontotemporal Dementia With Parkinsonism Mstd Frontotemporal Lobar Degeneration With Tau Inclusions Ftld With Tau Inclusions Dementia, Frontotemporal, With Parkinsonism Fldem Ftdp17 Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex Ddpac Wilhelmsen-Lynch Disease Wld Ppnd Dementia, Frontotemporal, With Or Without Parkinsonism Semantic Primary Progressive Aphasia Semantic Variant Ppa Wilhemsen-Lynch Disease Frontotemporal Dementia-Amyotrophic Lateral Sclerosis Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17 Ftd-Als Ftld Pick Complex Pick Disease Of The Brain Frontotemporal Dementia With Parkinsonism-17 Grn-Related Frontotemporal Dementia Frontotemporal Dementia With Motor Neuron Disease Dementia In Fronto-Temporal Lobar Degeneration Ftd - [Frontotemporal Dementia] Temple Dementia Frontal Lobe Dementia
Wilms Tumor 1	Nephroblastoma Wilms Tumor WT1 Wilms' Tumor Bilateral Wilms Tumor Wilms Tumor, Type 1 Wilms Tumor, Somatic Adult Nephroblastoma Wt1 Disorder Renal Embryonic Tumor Adult Kidney Wilms Tumor Childhood Kidney Wilms Tumor Nonanaplastic Kidney Wilms Tumor
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06265	HNRNPC Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19512	Hnrnpc Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26006	Hnrnpc Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	HNRNPC	RGD	RGD:1309982
Mus musculus	HNRNPC	MGD	MGI:107795
Macaca mulatta	HNRNPC	VGNC	VGNC:84348