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KPNA5 - karyopherin subunit alpha 5 Gene

Also Known as SRP6; IPOA6

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3841

About KPNA5

Cytogenetic location: 6q22.1 Genomic coordinates (GRCh38): 6:116,681,211-116,741,867 (from NCBI)

This gene has 7 transcripts (splice variants), 184 orthologues and 6 paralogues. Broad expression in testis (RPKM 10.4), ovary (RPKM 8.3) and 24 other tissues.

Summary

The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC) which consists of 60-100 proteins and is probably 120 million daltons in molecular size. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion; larger molecules are transported by an active process. Most nuclear proteins contain short basic amino acid sequences known as nuclear localization signals (NLSs). KPNA5 protein belongs to the importin alpha protein family and is thought to be involved in NLS-dependent protein import into the nucleus. [provided by RefSeq, Jul 2008]

KPNA5 Products (8)

mRNA	Protein	Name
NM_001366304.1	NP_001353233.1	importin subunit alpha-6 isoform a
NM_001366305.2	NP_001353234.1	importin subunit alpha-6 isoform a
NM_001366306.2	NP_001353235.1	importin subunit alpha-6 isoform b
NM_001366307.2	NP_001353236.1	importin subunit alpha-6 isoform c
NM_001366308.1	NP_001353237.1	importin subunit alpha-6 isoform d
NM_001366309.2	NP_001353238.1	importin subunit alpha-6 isoform e
NM_001366310.2	NP_001353239.1	importin subunit alpha-6 isoform f
NM_002269.3	NP_002260.2	importin subunit alpha-6 isoform b

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15057270	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KPNA5 Protein Structure

IBB

Arm

0
100
200
300
400
500
539 a.a.

Protein Preferred Names	Protein Names
importin subunit alpha-6	importin alpha 6

KPNA5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	KPNA5	O15131	NRF1	Homo sapiens	Q16656-4	Validated Y2H	32296183
Intra	KPNA5	O15131	POU6F2	Homo sapiens	P78424	Validated Y2H	32296183
Intra	KPNA5	O15131	NUP50	Homo sapiens	Q9UKX7	Validated Y2H	25416956
Intra	KPNA5	O15131	NUP50	Homo sapiens	Q9UKX7	Validated Y2H	32296183
Intra	KPNA5	O15131	NUP50	Homo sapiens	Q9UKX7	Y2H Prey Pooling	25416956
Intra	KPNA5	O15131	TSEN54	Homo sapiens	Q7Z6J9	Validated Y2H	32296183
Intra	KPNA5	O15131	ZNF326	Homo sapiens	Q5BKZ1	Validated Y2H	32296183
Intra	KPNA5	O15131	SPOPL	Homo sapiens	Q6IQ16	Anti Tag CoIP	33961781
Intra	KPNA5	O15131	SPOPL	Homo sapiens	Q6IQ16	Y2H Array	25416956
Intra	KPNA5	O15131	CFTR	Homo sapiens	P13569	Ub Reconstruction	35156780
Intra	KPNA5	O15131	HNRNPC	Homo sapiens	P07910	Validated Y2H	32296183
Intra	KPNA5	O15131	DCPS	Homo sapiens	Q96C86	Validated Y2H	32296183
Intra	KPNA5	O15131	NMNAT1	Homo sapiens	Q9HAN9	Validated Y2H	32296183
Intra	KPNA5	O15131	KAT5	Homo sapiens	Q92993	Validated Y2H	32296183
Intra	KPNA5	O15131	CDKN1B	Homo sapiens	P46527	Anti Tag CoIP	22770219
Intra	KPNA5	O15131	CDKN1B	Homo sapiens	P46527	Pull Down	15057270
Intra	KPNA5	O15131	POLR3C	Homo sapiens	Q9BUI4	Validated Y2H	32296183
Intra	KPNA5	O15131	RAD52	Homo sapiens	P43351	Validated Y2H	32296183
Intra	KPNA5	O15131	MLH1	Homo sapiens	P40692	Validated Y2H	32296183
Intra	KPNA5	O15131	ATOSB	Homo sapiens	Q7L5A3	Validated Y2H	32296183
Intra	KPNA5	O15131	ANP32B	Homo sapiens	Q92688	Y2H Prey Pooling	25416956
Intra	KPNA5	O15131	ANP32B	Homo sapiens	Q92688	Validated Y2H	25416956
Intra	KPNA5	O15131	ANP32B	Homo sapiens	Q92688	Validated Y2H	32296183
Intra	KPNA5	O15131	ANP32B	Homo sapiens	Q92688	Y2H Array	25416956
Intra	KPNA5	O15131	LMNB1	Homo sapiens	P20700	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

KPNA5 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P810031	karyopherin α5 Antibody (YA9375)	WB, ICC/IF, IF-Tissue, IP, ELISA	human

Related Diseases

Diseases	Alias
Influenza	Flu Influenza With Non-Respiratory Manifestation Influenza With Other Manifestations Influenza, Human Influenza, Susceptibility To Seasonal Influenza, Virus Identified
Arthrogryposis, Distal, Type 1a	Distal Arthrogryposis Type 1 Digitotalar Dysmorphism DA1A Da1 Amcd1 Arthrogryposis, Distal, Type 2b4 Distal Arthrogryposis Type 1a Arthrogryposis, Distal, Type 1 Arthrogryposis Multiplex Congenita Distal Type 1 Arthrogryposis Multiplex Congenita, Distal Type 1 Arthrogryposis Multiplex Congenita, Distal, Type I Distal Arthrogryposis Type 1b Arthrogryposis, Distal, 1a Amc Arthrogryposis Multiplex Congenita Arthrogryposis, Distal, 2b4 DA2B4 Arthrogryposis Multiplex Congenita, Distal, Type 1 Arthrogryposis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07419	KPNA5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	KPNA5	VGNC	VGNC:30704
Canis familiaris	KPNA5	VGNC	VGNC:42503
Rattus norvegicus	KPNA5	RGD	RGD:1561324
Felis catus	KPNA5	VGNC	VGNC:67977
Macaca mulatta	KPNA5	VGNC	VGNC:81085
Others	KPNA5	NCBI