2. Gene
  3. KPNA5 - karyopherin subunit alpha 5 Gene

KPNA5 - karyopherin subunit alpha 5 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as SRP6; IPOA6

Gene ID: 3841 | Gene type: protein coding

About KPNA5

Cytogenetic location: 6q22.1 Genomic coordinates (GRCh38): 6:116,681,211-116,741,867 (from NCBI)

This gene has 7 transcripts (splice variants), 184 orthologues and 6 paralogues. Broad expression in testis (RPKM 10.4), ovary (RPKM 8.3) and 24 other tissues.

Summary

The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC) which consists of 60-100 proteins and is probably 120 million daltons in molecular size. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion; larger molecules are transported by an active process. Most nuclear proteins contain short basic amino acid sequences known as nuclear localization signals (NLSs). KPNA5 protein belongs to the importin alpha protein family and is thought to be involved in NLS-dependent protein import into the nucleus. [provided by RefSeq, Jul 2008]

KPNA5 Products(8)

mRNA Protein Name
NM_001366304.1 NP_001353233.1 importin subunit alpha-6 isoform a
NM_001366305.2 NP_001353234.1 importin subunit alpha-6 isoform a
NM_001366306.2 NP_001353235.1 importin subunit alpha-6 isoform b
NM_001366307.2 NP_001353236.1 importin subunit alpha-6 isoform c
NM_001366308.1 NP_001353237.1 importin subunit alpha-6 isoform d
NM_001366309.2 NP_001353238.1 importin subunit alpha-6 isoform e
NM_001366310.2 NP_001353239.1 importin subunit alpha-6 isoform f
NM_002269.3 NP_002260.2 importin subunit alpha-6 isoform b

KPNA5 Protein Structure

IBB

IBB: Importin beta binding domain (6 - 96)

Arm

Arm: Armadillo/beta-catenin-like repeat (116 - 157)

Arm

Arm: Armadillo/beta-catenin-like repeat (163 - 198)

Arm

Arm: Armadillo/beta-catenin-like repeat (201 - 242)

Arm

Arm: Armadillo/beta-catenin-like repeat (256 - 284)

Arm

Arm: Armadillo/beta-catenin-like repeat (287 - 325)

Arm

Arm: Armadillo/beta-catenin-like repeat (331 - 368)

Arm

Arm: Armadillo/beta-catenin-like repeat (370 - 409)

Arm

Arm: Armadillo/beta-catenin-like repeat (413 - 452)

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  • 539 a.a.
Protein Preferred Names Protein Names

importin subunit alpha-6

importin alpha 6

Related Diseases

Diseases Alias
Influenza

Flu

Influenza With Non-Respiratory Manifestation

Influenza With Other Manifestations

Influenza, Human

Influenza, Susceptibility To

Seasonal Influenza, Virus Identified
Arthrogryposis, Distal, Type 1a

Distal Arthrogryposis Type 1

Digitotalar Dysmorphism

DA1A

Da1

Amcd1

Arthrogryposis, Distal, Type 2b4

Distal Arthrogryposis Type 1a

Arthrogryposis, Distal, Type 1

Arthrogryposis Multiplex Congenita Distal Type 1

Arthrogryposis Multiplex Congenita, Distal Type 1

Arthrogryposis Multiplex Congenita, Distal, Type I

Distal Arthrogryposis Type 1b

Arthrogryposis, Distal, 1a

Amc

Arthrogryposis Multiplex Congenita

Arthrogryposis, Distal, 2b4

DA2B4

Arthrogryposis Multiplex Congenita, Distal, Type 1

Arthrogryposis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07419 KPNA5 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus KPNA5 VGNC VGNC:30704
Canis familiaris KPNA5 VGNC VGNC:42503
Rattus norvegicus KPNA5 RGD RGD:1561324
Felis catus KPNA5 VGNC VGNC:67977
Macaca mulatta KPNA5 VGNC VGNC:81085