SPOPL - speckle type BTB/POZ protein like Gene

Homo sapiens

Also known as BTBD33

Gene ID: 339745 | Gene type: protein coding

About SPOPL

This gene has 4 transcripts (splice variants), 227 orthologues and 11 paralogues. Ubiquitous expression in appendix (RPKM 7.5), lymph node (RPKM 7.4) and 25 other tissues.

Summary

Predicted to enable ubiquitin protein ligase binding activity. Involved in negative regulation of protein ubiquitination and proteasome-mediated ubiquitin-dependent protein catabolic process. Part of Cul3-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]

SPOPL Products(1)

mRNA	Protein	Name
NM_001001664.3	NP_001001664.1	speckle-type POZ protein-like

SPOPL Protein Structure

MATH

BTB

0
100
200
300
392 a.a.

Protein Preferred Names

Protein Names

speckle-type POZ protein-like

HIB homolog 2

Related Diseases

Diseases

Alias

Meier-Gorlin Syndrome 2

MGORS2

Meier-Gorlin Syndrome, Type 2

Epilepsy, Idiopathic Generalized 9

Epilepsy, Idiopathic Generalized, Susceptibility To, 9	EIG9
Epilepsy, Juvenile Myoclonic 6	Idiopathic Generalized Epilepsy 9
Epilepsy, Juvenile Myoclonic, Susceptibility To, 6	Susceptibility To Idiopathic Generalized Epilepsy 9
Juvenile Myoclonic Epilepsy 6	EJM6
Susceptibility To Juvenile Myoclonic Epilepsy 6	Epilepsy, Idiopathic, Generalized, Susceptibility To, Type 9

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13701	SPOPL Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SPOPL	VGNC	VGNC:35230
Macaca mulatta	SPOPL	VGNC	VGNC:78007
Mus musculus	SPOPL	MGD	MGI:1924107
Rattus norvegicus	SPOPL	RGD	RGD:1305847
Felis catus	SPOPL	VGNC	VGNC:107636
Canis familiaris	SPOPL	VGNC	VGNC:46754

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