SPOPL - speckle type BTB/POZ protein like Gene

Also Known as BTBD33

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 339745

About SPOPL

This gene has 4 transcripts (splice variants), 227 orthologues and 11 paralogues. Ubiquitous expression in appendix (RPKM 7.5), lymph node (RPKM 7.4) and 25 other tissues.

Summary

Predicted to enable ubiquitin protein Ligase binding activity. Involved in negative regulation of protein ubiquitination and proteasome-mediated ubiquitin-dependent protein catabolic process. Part of Cul3-RING ubiquitin Ligase complex. [provided by Alliance of Genome Resources, Apr 2022]

SPOPL Products (1)

mRNA	Protein	Name
NM_001001664.3	NP_001001664.1	speckle-type POZ protein-like

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	22632832	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	22632832	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of protein ubiquitination	IMP IMP: Inferred from mutant phenotype	22632832	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	22632832	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of Cul3-RING ubiquitin ligase complex	IDA IDA: Inferred from direct assay	22632832	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SPOPL Protein Structure

MATH

BTB

0
100
200
300
392 a.a.

Protein Preferred Names	Protein Names
speckle-type POZ protein-like	HIB homolog 2

SPOPL Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SPOPL	Q6IQ16	KPNA5	Homo sapiens	O15131	Y2H Prey Pooling	25416956
Intra	SPOPL	Q6IQ16	CUL3	Homo sapiens	Q13618	ITC	22632832
Intra	SPOPL	Q6IQ16	SPOP	Homo sapiens	O43791	Anti Tag CoIP	33961781
Intra	SPOPL	Q6IQ16	SPOP	Homo sapiens	O43791	GMS	22632832
Intra	SPOPL	Q6IQ16	MYD88	Homo sapiens	Q99836	Validated Y2H	32296183
Intra	SPOPL	Q6IQ16	KPNA5	Homo sapiens	O15131	Y2H Array	31515488
Intra	SPOPL	Q6IQ16	KPNA5	Homo sapiens	O15131	Validated Y2H	25416956
Intra	SPOPL	Q6IQ16	SPOPL	Homo sapiens	Q6IQ16	GMS	22632832

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Meier-Gorlin Syndrome 2	MGORS2 Meier-Gorlin Syndrome, Type 2
Epilepsy, Idiopathic Generalized 9	Epilepsy, Idiopathic Generalized, Susceptibility To, 9 EIG9 Epilepsy, Juvenile Myoclonic 6 Idiopathic Generalized Epilepsy 9 Epilepsy, Juvenile Myoclonic, Susceptibility To, 6 Susceptibility To Idiopathic Generalized Epilepsy 9 Juvenile Myoclonic Epilepsy 6 EJM6 Susceptibility To Juvenile Myoclonic Epilepsy 6 Epilepsy, Idiopathic, Generalized, Susceptibility To, Type 9

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13701	SPOPL Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SPOPL	VGNC	VGNC:35230
Macaca mulatta	SPOPL	VGNC	VGNC:78007
Mus musculus	SPOPL	MGD	MGI:1924107
Rattus norvegicus	SPOPL	RGD	RGD:1305847
Felis catus	SPOPL	VGNC	VGNC:107636
Canis familiaris	SPOPL	VGNC	VGNC:46754
Others	SPOPL	NCBI