SPOP - speckle type BTB/POZ protein Gene

Homo sapiens

Also known as TEF2; BTBD32; NSDVS1; NSDVS2; NEDMACE; NEDMIDF

Gene ID: 8405 | Gene type: protein coding

About SPOP

Cytogenetic location: 17q21.33 Genomic coordinates (GRCh38): 17:49,598,884-49,678,163 (from NCBI)

This gene has 25 transcripts (splice variants), 340 orthologues, 11 paralogues and is associated with 91 phenotypes. Ubiquitous expression in prostate (RPKM 17.8), esophagus (RPKM 16.2) and 25 other tissues.

Summary

This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

SPOP Products(9)

mRNA	Protein	Name
NM_001007226.1	NP_001007227.1	speckle-type POZ protein
NM_001007227.1	NP_001007228.1	speckle-type POZ protein
NM_001007228.2	NP_001007229.1	speckle-type POZ protein
NM_001007229.1	NP_001007230.1	speckle-type POZ protein
NM_001007230.1	NP_001007231.1	speckle-type POZ protein
NM_001370730.1	NP_001357659.1	speckle-type POZ protein
NM_001370731.1	NP_001357660.1	speckle-type POZ protein
NM_001370732.1	NP_001357661.1	speckle-type POZ protein
NM_003563.3	NP_003554.1	speckle-type POZ protein

SPOP Protein Structure

MATH

BTB

0
100
200
300
374 a.a.

Protein Preferred Names

Protein Names

speckle-type POZ protein

HIB homolog 1

Related Diseases

Diseases

Alias

Nabais Sa-De Vries Syndrome, Type 1

Neurodevelopmental Disorder With Microcephaly And Dysmorphic Facies	NSDVS1
Nedmidf	Nabais Sa-De Vries Syndrome 1

Nabais Sa-De Vries Syndrome, Type 2

Neurodevelopmental Disorder With Relative Macrocephaly And With Or Without Cardiac Or Endocrine Anomalies	NSDVS2
Nedmace	Nabais Sa-De Vries Syndrome 2

Suppression Of Tumorigenicity 12

Prostate Adenocarcinoma	Adenocarcinoma Of Prostate
ST12	Prostate Adenocarcinoma 1
Pac1

Uterine Corpus Endometrial Carcinoma

Joubert Syndrome 32

JBTS32

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Primary Cutaneous Amyloidosis

Plca	Primary Localized Cutaneous Amyloidosis
Familial Primary Localized Cutaneous Amyloidosis	Amyloidosis Ix
Lichen Amyloidosis Familial	Amyloidosis, Primary Cutaneous
Pca	Amyloidosis 9
Amyloidosis Familial Cutaneous Lichen	Fplca
Familial Lichen Amyloidosis

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-136938	NEO2734	Inhibitor	99.79%	Phase 1

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-122615	SPOP-IN-6b	Inhibitor	99.58%	Unkown
HY-122615B	SPOP-IN-6b dihydrochloride	Inhibitor	99.90%	Unkown
HY-122615A	SPOP-IN-6b hydrochloride	Inhibitor	/	Unkown
HY-156382	SPOP-IN-1	Inhibitor	/	Unkown
HY-161251	SPOP-IN-2		/	Unkown
HY-RS13700	SPOP Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SPOP	VGNC	VGNC:65643
Mus musculus	SPOP	MGD	MGI:1343085
Bos taurus	SPOP	VGNC	VGNC:35229
Rattus norvegicus	SPOP	RGD	RGD:1311613
Canis familiaris	SPOP	VGNC	VGNC:46753
Macaca mulatta	SPOP	VGNC	VGNC:77863

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