SPOP - speckle type BTB/POZ protein Gene

Also Known as TEF2; BTBD32; NSDVS1; NSDVS2; NEDMACE; NEDMIDF

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8405

About SPOP

Cytogenetic location: 17q21.33 Genomic coordinates (GRCh38): 17:49,598,884-49,678,163 (from NCBI)

This gene has 25 transcripts (splice variants), 340 orthologues, 11 paralogues and is associated with 91 phenotypes. Ubiquitous expression in prostate (RPKM 17.8), esophagus (RPKM 16.2) and 25 other tissues.

Summary

This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and Other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in Other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

SPOP Products (9)

mRNA Protein Name
NM_001007226.1 NP_001007227.1 speckle-type POZ protein
NM_001007227.1 NP_001007228.1 speckle-type POZ protein
NM_001007228.2 NP_001007229.1 speckle-type POZ protein
NM_001007229.1 NP_001007230.1 speckle-type POZ protein
NM_001007230.1 NP_001007231.1 speckle-type POZ protein
NM_001370730.1 NP_001357659.1 speckle-type POZ protein
NM_001370731.1 NP_001357660.1 speckle-type POZ protein
NM_001370732.1 NP_001357661.1 speckle-type POZ protein
NM_003563.3 NP_003554.1 speckle-type POZ protein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
22632832 GOA
enables molecular function inhibitor activity EXP
EXP: Inferred from Experiment
31624231 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
enables ubiquitin protein ligase binding IPI
IPI: Inferred from physical interaction
11279055 GOA
Biological Process GO Annotation Evidence References Source
involved in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
22085717 GOA
involved in protein polyubiquitination IDA
IDA: Inferred from direct assay
14528312 GOA
Cellular Component GO Annotation Evidence References Source
part of Cul3-RING ubiquitin ligase complex IDA
IDA: Inferred from direct assay
14528312 GOA
located in nucleus IDA
IDA: Inferred from direct assay
22085717 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SPOP Protein Structure

MATH

MATH: MATH domain (38 - 163)

BTB

BTB: BTB/POZ domain (193 - 296)

  • 0
  • 100
  • 200
  • 300
  • 374 a.a.
Protein Preferred Names Protein Names

speckle-type POZ protein

  • HIB homolog 1

SPOP Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SPOP O43791 DUSP7 Homo sapiens Q16829
Anti Tag CoIP
24656772
Intra
SPOP O43791 DUSP7 Homo sapiens Q16829
Ubiquitinase Assay
24656772
Intra
SPOP O43791 MYD88 Homo sapiens Q99836
Y2H
21988832
Intra
SPOP O43791 MYD88 Homo sapiens Q99836
Anti Tag CoIP
21988832
Intra
SPOP O43791 MYD88 Homo sapiens Q99836
Pull Down
21988832
Intra
SPOP O43791 MYD88 Homo sapiens Q99836
Confocal
21988832
Intra
SPOP O43791 CUL3 Homo sapiens Q13618
ITC
22632832
Intra
SPOP O43791 CUL3 Homo sapiens Q13618
X-Ray Diffraction
22632832
Intra
SPOP O43791 CUL3 Homo sapiens Q13618
GMS
22632832
Intra
SPOP O43791 PTEN Homo sapiens P60484
Anti Tag CoIP
24656772
Intra
SPOP O43791 PTEN Homo sapiens P60484
Ubiquitinase Assay
24656772
Intra
SPOP O43791 DAXX Homo sapiens Q9UER7
Y2H Array
21988832
Intra
SPOP O43791 DAXX Homo sapiens Q9UER7
Y2H
21988832
Intra
SPOP O43791 DAXX Homo sapiens Q9UER7
Confocal
21988832
Intra
SPOP O43791 NCOA3 Homo sapiens Q9Y6Q9
Pull Down
21577200
Intra
SPOP O43791 NCOA3 Homo sapiens Q9Y6Q9
Anti Tag CoIP
21577200
Cross: Cross-species interaction Intra: Intraspecies interaction

SPOP Antibodies

Cat. No. Product Name Application Reactivity
HY-P82309 SPOP Antibody (YA2054) WB Human
HY-P82309A SPOP Antibody (YA2054)(PBS only) WB Human

Related Diseases

Diseases Alias
Nabais Sa-De Vries Syndrome, Type 1

  • Neurodevelopmental Disorder With Microcephaly And Dysmorphic Facies

  • NSDVS1

  • Nedmidf

  • Nabais Sa-De Vries Syndrome 1
Nabais Sa-De Vries Syndrome, Type 2

  • Neurodevelopmental Disorder With Relative Macrocephaly And With Or Without Cardiac Or Endocrine Anomalies

  • NSDVS2

  • Nedmace

  • Nabais Sa-De Vries Syndrome 2
Suppression Of Tumorigenicity 12

  • Prostate Adenocarcinoma

  • Adenocarcinoma Of Prostate

  • ST12

  • Prostate Adenocarcinoma 1

  • Pac1
Uterine Corpus Endometrial Carcinoma
Joubert Syndrome 32

  • JBTS32
Prostate Cancer

  • Prostate Carcinoma

  • Prostate Cancer, Familial

  • Prostate Neoplasm

  • Prostate Cancer, Somatic

  • Prostate Cancer, Susceptibility To

  • Prostatic Cancer

  • Prostatic Neoplasms

  • Hereditary Prostate Cancer

  • Prostatic Neoplasm

  • Cancer Of Prostate

  • Carcinoma Of Prostate

  • Familial Prostate Cancer

  • Familial Prostate Carcinoma

  • Malignant Tumor Of Prostate

  • Malignant Neoplasm Of Prostate

  • Prostate Cancer, Familial, Susceptibility To

  • Malignant Tumor Of The Prostate

  • Ngp - New Growth Of Prostate

  • Tumor Of The Prostate

  • Prostate Cancer, Hereditary

  • Cancer Of The Prostate

  • Malignant Neoplasm Of The Prostate

  • Prostatic Carcinoma

  • PC

  • Prca

  • Cancer, Prostate

  • Malignant Prostatic Tumour

  • Malignant Tumour Of Prostate

  • Primary Prostate Cancer

  • Primary Malignant Neoplasm Of Prostate

  • Prostate Gland Cancer
Primary Cutaneous Amyloidosis

  • Plca

  • Primary Localized Cutaneous Amyloidosis

  • Familial Primary Localized Cutaneous Amyloidosis

  • Amyloidosis Ix

  • Lichen Amyloidosis Familial

  • Amyloidosis, Primary Cutaneous

  • Pca

  • Amyloidosis 9

  • Amyloidosis Familial Cutaneous Lichen

  • Fplca

  • Familial Lichen Amyloidosis
Microcephaly

  • Microencephaly

  • Microcephalus

  • Microcephalic

  • Nanocephaly

  • Congenital Microcephaly

  • Brain Hypoplasia

  • Brain Nondevelopment

  • Cephalic Hypoplasia

  • Undeveloped Cerebrum

  • Undeveloped Brain

  • Micrencephalon

  • Micrencephaly
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-176036 MS1262 98.61% Unkown

Orthologs Information

Species Symbol Source ID
Felis catus SPOP VGNC VGNC:65643
Mus musculus SPOP MGD MGI:1343085
Bos taurus SPOP VGNC VGNC:35229
Rattus norvegicus SPOP RGD RGD:1311613
Canis familiaris SPOP VGNC VGNC:46753
Macaca mulatta SPOP VGNC VGNC:77863
Others SPOP NCBI