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SPOP-IN-6b 

Cat. No.: HY-122615
Handling Instructions

SPOP-IN-6b is a speckle-type POZ protein (SPOP) inhibitor extracted from patent CN 107141287, SPOP-B-88.

For research use only. We do not sell to patients.

SPOP-IN-6b Chemical Structure

SPOP-IN-6b Chemical Structure

CAS No. : 2136270-20-5

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Description

SPOP-IN-6b is a speckle-type POZ protein (SPOP) inhibitor extracted from patent CN 107141287, SPOP-B-88[1].

IC50 & Target

SPOP[1]

In Vitro

SPOP-IN-6b a SPOP inhibitor with an IC50 of 3.58 μM in cell assay[1].
SPOP-IN-6b (0.1-3.0 μM; 10 hours) can suppress SPOP activity, and then increase suppression cancer substrate protein PTEN and DUSP7 content[1].
SPOP-IN-6b suppresses intracellular SPOP acted on substrate PTEN ubiquitination[1].

Cell Viability Assay[1]

Cell Line: A498 cells
Concentration: 0.1 μM, 0.3 μM, 1.0 μM, 3.0 μM
Incubation Time: 10 hours
Result: Suppress SPOP activity, and then increase suppression cancer substrate protein PTEN and DUSP7 content.
In Vivo

SPOP-IN-6b (40-80 mg/kg; i.p.; daily; for 25 days) can slow down the growth of tumour by suppressing SPOP[1].

Animal Model: Nude mice[1]
Dosage: 40 mg/kg, 60 mg/kg, 80 mg/kg
Administration: Intraperitoneal injection; daily; for 25 days
Result: Slowed down the growth of tumour by suppressing SPOP.
Molecular Weight

500.59

Formula

C₂₈H₃₂N₆O₃

CAS No.

2136270-20-5

SMILES

O=C(C(C(N1CCC2=CC=CC=C2)=N)=CC3=C1N=C(C(C)=CC=C4)N4C3=O)NCCCN5CCOCC5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

SPOP-IN-6bOthersRenalcellcarcinomaRCCSPOPInhibitorinhibitorinhibit

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