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SPOP-IN-6b 

Cat. No.: HY-122615 Purity: 99.61%
Handling Instructions

SPOP-IN-6b is a speckle-type POZ protein (SPOP) inhibitor extracted from patent CN 107141287, SPOP-B-88.

For research use only. We do not sell to patients.

SPOP-IN-6b Chemical Structure

SPOP-IN-6b Chemical Structure

CAS No. : 2136270-20-5

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 385 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 550 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1650 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2250 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

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Based on 1 publication(s) in Google Scholar

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Description

SPOP-IN-6b is a speckle-type POZ protein (SPOP) inhibitor extracted from patent CN 107141287, SPOP-B-88[1].

IC50 & Target

SPOP[1]

In Vitro

SPOP-IN-6b a SPOP inhibitor with an IC50 of 3.58 μM in cell assay[1].
SPOP-IN-6b (0.1-3.0 μM; 10 hours) can suppress SPOP activity, and then increase suppression cancer substrate protein PTEN and DUSP7 content[1].
SPOP-IN-6b suppresses intracellular SPOP acted on substrate PTEN ubiquitination[1].

Cell Viability Assay[1]

Cell Line: A498 cells
Concentration: 0.1 μM, 0.3 μM, 1.0 μM, 3.0 μM
Incubation Time: 10 hours
Result: Suppress SPOP activity, and then increase suppression cancer substrate protein PTEN and DUSP7 content.
In Vivo

SPOP-IN-6b (40-80 mg/kg; i.p.; daily; for 25 days) can slow down the growth of tumour by suppressing SPOP[1].

Animal Model: Nude mice[1]
Dosage: 40 mg/kg, 60 mg/kg, 80 mg/kg
Administration: Intraperitoneal injection; daily; for 25 days
Result: Slowed down the growth of tumour by suppressing SPOP.
Molecular Weight

500.59

Formula

C₂₈H₃₂N₆O₃

CAS No.

2136270-20-5

SMILES

O=C(C(C(N1CCC2=CC=CC=C2)=N)=CC3=C1N=C(C(C)=CC=C4)N4C3=O)NCCCN5CCOCC5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (19.98 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9976 mL 9.9882 mL 19.9764 mL
5 mM 0.3995 mL 1.9976 mL 3.9953 mL
10 mM 0.1998 mL 0.9988 mL 1.9976 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1 mg/mL (2.00 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 1 mg/mL (2.00 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

SPOP-IN-6bOthersRenalcellcarcinomaRCCSPOPInhibitorinhibitorinhibit

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SPOP-IN-6b
Cat. No.:
HY-122615
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