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SPOP-IN-6b dihydrochloride 

Cat. No.: HY-122615B Purity: 99.90%
Handling Instructions

SPOP-IN-6b dihydrochloride is a potent speckle-type POZ protein (SPOP) inhibitor with an IC50 of 3.58 μM.

For research use only. We do not sell to patients.

SPOP-IN-6b dihydrochloride Chemical Structure

SPOP-IN-6b dihydrochloride Chemical Structure

Size Price Stock Quantity
5 mg USD 250 In-stock
Estimated Time of Arrival: December 31
10 mg USD 420 In-stock
Estimated Time of Arrival: December 31
25 mg USD 890 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1500 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2250 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of SPOP-IN-6b dihydrochloride:

Top Publications Citing Use of Products

1 Publications Citing Use of MCE SPOP-IN-6b dihydrochloride

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

SPOP-IN-6b dihydrochloride is a potent speckle-type POZ protein (SPOP) inhibitor with an IC50 of 3.58 μM[1].

In Vitro

SPOP-IN-6b dihydrochloride shows IC50s of 2-10.2 μM for A498, Caki-2, Ketr-3, 769-P, 0S-RC-2, and 786-0 cells[1].
SPOP-IN-6b (0.1-3.0 μM; 10 hours) dihydrochloride can suppress SPOP activity, and then increase suppression cancer substrate protein PTEN and DUSP7 content[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SPOP-IN-6b (40-80 mg/kg; intraperitoneal injection; daily; for 25 days; nude mice) dihydrochloride can slow down the growth of tumour by suppressing SPOP[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

573.51

Formula

C₂₈H₃₄Cl₂N₆O₃

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 41.67 mg/mL (72.66 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7436 mL 8.7182 mL 17.4365 mL
5 mM 0.3487 mL 1.7436 mL 3.4873 mL
10 mM 0.1744 mL 0.8718 mL 1.7436 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (3.63 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
SPOP-IN-6b dihydrochloride
Cat. No.:
HY-122615B
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