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Cat. No.: HY-122615A

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SPOP-IN-6b hydrochloride

Name: SPOP-IN-6b hydrochloride
Brand: MedChemExpress
SKU: HY-122615A
Availability: PreOrder

3 Cited Publications

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Based on 3 publication(s) in Google Scholar

SPOP-IN-6b hydrochloride is a potent speckle-type POZ protein (SPOP) inhibitor with an IC₅₀ of 3.58 μM.

For research use only. We do not sell to patients.

CAS No.: 2136270-68-1
Formula: C₂₈H₃₃ClN₆O₃
Molecular Weight:537.05

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

SPOP-IN-6b hydrochloride Chemical Structure

CAS No.: 2136270-68-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Publications (3)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

SPOP-IN-6b hydrochloride is a potent speckle-type POZ protein (SPOP) inhibitor with an IC₅₀ of 3.58 μM^[1].

In Vitro

SPOP-IN-6b shows IC₅₀s of 2-10.2 μM for A498, Caki-2, Ketr-3, 769-P, 0S-RC-2 and 786-0 cells^[1].
SPOP-IN-6b (0.1-3.0 μM; 10 hours) can suppress SPOP activity, and then increase suppression cancer substrate protein PTEN and DUSP7 content^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SPOP-IN-6b (40-80 mg/kg; intraperitoneal injection; daily; for 25 days; nude mice) can slow down the growth of tumour by suppressing SPOP^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2136270-68-1
Molecular Weight 537.05
Formula C₂₈H₃₃ClN₆O₃
SMILES

O=C(C(C(N1CCC2=CC=CC=C2)=N)=CC3=C1N=C(C(C)=CC=C4)N4C3=O)NCCCN5CCOCC5.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (3)

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Mol Cell

Stabilization of ERK-Phosphorylated METTL3 by USP5 Increases m6A Methylation. [Abstract]

2020 Nov 19;80(4):633-647.e7. PMID: 33217317
J Clin Invest

Molecular glue degrader function of SPOP enhances STING-dependent immunotherapy efficacy in melanoma models. [Abstract]

2025 Oct 28:e191772. PMID: 41148213
Cell Rep

Harnessing the E3 ligase SPOP for targeted degradation of the NUP98::KDM5A fusion oncoprotein. [Abstract]

2025 Nov 25;44(12):116602. PMID: 41307993

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Guangcai Y, et al. The pyrido-pyrimidines of 2- imines -5- ketone group -2,5- dihydros -1-H- two. CN107141287A.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

SPOP-IN-6b hydrochloride

3 Cited Publications

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Biological Activity
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- In Vivo
Chemical Information
Publications (3)
Purity & Documentation
References

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SPOP-IN-6b hydrochloride

Publications Citing Use of MedChemExpress (MCE) SPOP-IN-6b hydrochloride

Biological Activity

Chemical Information

Publications (3)

Purity & Documentation

References

Calculators

Help & FAQs

SPOP-IN-6b hydrochloride Related Classifications

HY-122615A Related Classifications

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