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  4. SPOP-IN-6b hydrochloride

SPOP-IN-6b hydrochloride is a potent speckle-type POZ protein (SPOP) inhibitor with an IC50 of 3.58 μM.

For research use only. We do not sell to patients.

SPOP-IN-6b hydrochloride Chemical Structure

SPOP-IN-6b hydrochloride Chemical Structure

CAS No. : 2136270-68-1

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SPOP-IN-6b hydrochloride Related Antibodies

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Description

SPOP-IN-6b hydrochloride is a potent speckle-type POZ protein (SPOP) inhibitor with an IC50 of 3.58 μM[1].

In Vitro

SPOP-IN-6b shows IC50s of 2-10.2 μM for A498, Caki-2, Ketr-3, 769-P, 0S-RC-2 and 786-0 cells[1].
SPOP-IN-6b (0.1-3.0 μM; 10 hours) can suppress SPOP activity, and then increase suppression cancer substrate protein PTEN and DUSP7 content[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SPOP-IN-6b hydrochloride Related Antibodies
In Vivo

SPOP-IN-6b (40-80 mg/kg; intraperitoneal injection; daily; for 25 days; nude mice) can slow down the growth of tumour by suppressing SPOP[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

537.05

Formula

C28H33ClN6O3
CAS No.
SMILES

O=C(C(C(N1CCC2=CC=CC=C2)=N)=CC3=C1N=C(C(C)=CC=C4)N4C3=O)NCCCN5CCOCC5.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SPOP-IN-6b hydrochloride Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SPOP-IN-6b2136270-68-1OthersA498Caki-2tumorSPOPPTENDUSP7HK-2Inhibitorinhibitorinhibit

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