NCOA3 - nuclear receptor coactivator 3 Gene

Also Known as ACTR; AIB1; RAC3; SRC3; pCIP; AIB-1; CTG26; SRC-3; CAGH16; KAT13B; TNRC14; TNRC16; TRAM-1; bHLHe42

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8202

About NCOA3

Cytogenetic location: 20q13.12 Genomic coordinates (GRCh38): 20:47,501,887-47,656,872 (from NCBI)

This gene has 5 transcripts (splice variants), 269 orthologues and 2 paralogues. Ubiquitous expression in lymph node (RPKM 20.8), placenta (RPKM 19.0) and 25 other tissues.

Summary

The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has Histone Acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Several transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic repeat region is found in the C-terminus of the encoded protein. [provided by RefSeq, Mar 2010]

NCOA3 Products (4)

mRNA	Protein	Name
NM_001174087.2	NP_001167558.1	nuclear receptor coactivator 3 isoform c
NM_001174088.2	NP_001167559.1	nuclear receptor coactivator 3 isoform d
NM_006534.4	NP_006525.2	nuclear receptor coactivator 3 isoform b
NM_181659.3	NP_858045.1	nuclear receptor coactivator 3 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables disordered domain specific binding	IPI IPI: Inferred from physical interaction	11823864	GOA
enables histone acetyltransferase activity	IDA IDA: Inferred from direct assay	9267036	GOA
enables nuclear receptor binding	IDA IDA: Inferred from direct assay	9267036	GOA
enables nuclear receptor binding	IPI IPI: Inferred from physical interaction	18798693	GOA
enables nuclear receptor coactivator activity	IDA IDA: Inferred from direct assay	9267036	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11279242	GOA
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	9238002	GOA
enables transcription coactivator activity	IMP IMP: Inferred from mutant phenotype	17223341	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to estradiol stimulus	IDA IDA: Inferred from direct assay	15831516	GOA
involved in positive regulation of keratinocyte differentiation	IMP IMP: Inferred from mutant phenotype	17082781	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9267036	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	17082781	GOA
involved in retinoic acid receptor signaling pathway	IDA IDA: Inferred from direct assay	9267036	GOA
involved in vitamin D receptor signaling pathway	IDA IDA: Inferred from direct assay	9267036	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in chromatin	IDA IDA: Inferred from direct assay	9267036	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	17223341	GOA
located in nucleus	IDA IDA: Inferred from direct assay	17223341	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	19917671	GOA
part of protein-containing complex	IMP IMP: Inferred from mutant phenotype	11823864	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NCOA3 Protein Structure

PAS

PAS_11

SRC-1

Nuc_rec_co-act

DUF1518

0
300
600
900
1200
1420 a.a.

Protein Preferred Names	Protein Names
nuclear receptor coactivator 3	CBP-interacting protein

NCOA3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	NCOA3	Q9Y6Q9	Myocd	Mus musculus	Q8VIM5-1	Pull Down	17360478
Cross	NCOA3	Q9Y6Q9	Myocd	Mus musculus	Q8VIM5-1	Anti Tag CoIP	17360478
Intra	NCOA3	Q9Y6Q9	CARM1	Homo sapiens	Q86X55	Anti Bait CoIP	26267537
Cross	NCOA3	Q9Y6Q9	Vdr	Mus musculus	P48281	Y2H	12529369
Intra	NCOA3	Q9Y6Q9	PSME3	Homo sapiens	P61289	Anti Tag CoIP	16439211
Intra	NCOA3	Q9Y6Q9	PSME3	Homo sapiens	P61289	Anti Bait CoIP	16439211
Intra	NCOA3	Q9Y6Q9	PSME3	Homo sapiens	P61289	Pull Down	16439211
Intra	NCOA3	Q9Y6Q9	PSMB9	Homo sapiens	P28065	Pull Down	16957778
Intra	NCOA3	Q9Y6Q9	PSMB9	Homo sapiens	P28065	Anti Bait CoIP	16957778
Intra	NCOA3	Q9Y6Q9	PTEN	Homo sapiens	P60484	Anti Bait CoIP	23514585
Intra	NCOA3	Q9Y6Q9	SPOP	Homo sapiens	O43791	Anti Tag CoIP	21577200
Intra	NCOA3	Q9Y6Q9	SPOP	Homo sapiens	O43791	Pull Down	21577200
Intra	NCOA3	Q9Y6Q9	SPOP	Homo sapiens	O43791	Anti Bait CoIP	21577200
Intra	NCOA3	Q9Y6Q9	IKBKB	Homo sapiens	O14920	CoIP	11971985

Cross: Cross-species interaction Intra: Intraspecies interaction

NCOA3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P84918	NCoA-3 Antibody (YA4615)	WB, ELISA	Human
HY-P84918A	NCoA-3 Antibody (YA4615)(PBS only)	WB, ELISA	Human
HY-P85293	NCoA-3 Antibody (YA4985)	WB	Human

Related Diseases

Diseases	Alias
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Endometrial Hyperplasia
Endometrial Cancer	Endometrial Carcinoma Endometrial Neoplasm Malignant Neoplasm Of Endometrium Endometrioid Carcinoma Endometrial Neoplasms Carcinoma, Endometrioid Endometrial Cancer, Familial Endometrial Carcinoma, Somatic Endometrial Cancer, Susceptibility To Endometrial Ca Malignant Endometrial Neoplasm Neoplasm Of Endometrium Primary Malignant Neoplasm Of Endometrium Tumor Of Endometrium Carcinoma Of The Endometrium Endometrioid Carcinoma Of Female Reproductive System ENDMC Carcinoma Endometrioid Endometrial Cancers Cancer, Endometrial Uterine Corpus Cancer
Amelogenesis Imperfecta, Type Ig	Enamel-Renal Syndrome Ers Amelogenesis Imperfecta Type 1g AI1G Enamel-Renal-Gingival Syndrome Amelogenesis Imperfecta And Gingival Fibromatosis Syndrome Aigfs Amelogenesis Imperfecta, Hypoplastic, With Nephrocalcinosis Amelogenesis Imperfecta Hypoplastic With Nephrocalcinosis Amelogenesis Imperfecta Type Ig Amelogenesis Imperfecta-Nephrocalcinosis Syndrome Amelogenesis Imperfecta 1g Hypoplastic Amelogenesis Imperfecta With Nephrocalcinosis Amelogenesis Imperfecta Nephrocalcinosis
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Teeth Hard Tissue Disease
Acute Promyelocytic Leukemia	Leukemia, Acute Promyelocytic Acute Myeloblastic Leukemia Type 3 Aml M3 APL Leukemia, Acute Promyelocytic, Somatic Aml With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Apml Acute Myeloblastic Leukemia 3 Acute Myeloid Leukemia With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Acute Myeloblastic Leukaemia Type 3 Acute Myeloid Leukaemia M3 Acute Myeloid Leukemia M3 Acute Promyelocytic Leukaemia M3 Anll Myeloid Leukemia, Acute, M3 Leukemia Promyelocytic Acute Leukemia, Promyelocytic, Acute Leukemia, Acute, Promyelocytic
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Amelogenesis Imperfecta	Ai Congenital Enamel Hypoplasia Al - [Amelogenesis Imperfecta]
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset Obesity , Susceptibility To BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-173033	MI-883		99.57%	Unkown
HY-RS09091	NCOA3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-P11829	ACTR-AD1 2L	Inhibitor	/	Unkown
HY-RS20451	Ncoa3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26960	Ncoa3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	NCOA3	VGNC	VGNC:31921
Felis catus	NCOA3	VGNC	VGNC:68432
Macaca mulatta	NCOA3	VGNC	VGNC:75147
Rattus norvegicus	NCOA3	RGD	RGD:620109
Canis familiaris	NCOA3	VGNC	VGNC:54658
Mus musculus	NCOA3	MGD	MGI:1276535
Others	NCOA3	NCBI