NCoA-3 Antibody (YA4985)
(Synonyms: NCOA3; AIB1; BHLHE42; RAC3; TRAM1; Nuclear receptor coactivator 3; NCoA-3; ACTR; Amplified in breast cancer 1 protein; AIB-1; CBP-interacting protein; pCIP; Class E basic helix-loop-helix protein 42; bHLHe42; Receptor-associated coactivator)NCoA-3 Antibody (YA4985) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to NCoA-3.
-
Host:
Mouse
-
Isotype:
IgG1
-
Application:
WB
-
Reactivity :
Human
-
Formulation:
Supplied in purified antibody in PBS with 0.05% sodium azide.
-
Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
|
|---|---|
| Dilution Ratio | 1:500-1:1000 |
Product Details
NCoA-3 Antibody (YA4985) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to NCoA-3.
-
Host Mouse
-
Clonality Monoclonal
-
Species ReactivityHuman
-
Observed Molecular WeightObserved band size: 155 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
-
Calculated Molecular Weight Predicted band size: 155 kDa
Purified recombinant fragment of human AIB1 expressed in E. Coli. The exact sequence is proprietary to MCE.
Endogenous
Ascitic Fluid
Non-conjugated
Unmodified
IgG1
Product Properties
-
Appearance
Liquid
-
Formulation
Supplied in purified antibody in PBS with 0.05% sodium azide.
-
Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
-
Shipping
Shipping with blue ice.
Background
-
Function
NCoA-3 is a Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit
-
Subcellular Localization
Cytoplasm; Nucleus
-
Expression
Tissue_specificity:Widely expressed. Highly expressed in the heart, skeletal muscle, pancreas, and placenta. Lowly expressed in the brain, and extremely lowly expressed in the lungs, liver, and kidneys. -
Isoforms & Post-Translational Modification
Q9Y6Q9 has 5 isomers: Q9Y6Q9-1: 155293 Da (predicted); Q9Y6Q9-2: 153797 Da (predicted); Q9Y6Q9-3: 154400 Da (predicted); Q9Y6Q9-4: 147499 Da (predicted); Q9Y6Q9-5: 154892 Da (predicted).
Acetylated by CREBBP. Acetylation occurs in the RID domain, and disrupts the interaction with nuclear receptors and regulates its function;Methylated by CARM1;Phosphorylated by IKK complex. Regulated its function. Phosphorylation at Ser-601 by CK1 promotes coactivator function -
Subunit
Present in a complex containing NCOA2, IKKA, IKKB, IKBKG and the histone acetyltransferase protein CREBBP (PubMed:11971985, PubMed:9346901).
-
SwissProt ID
-
Synonyms
NCOA3; AIB1; BHLHE42; RAC3; TRAM1; Nuclear receptor coactivator 3; NCoA-3; ACTR; Amplified in breast cancer 1 protein; AIB-1; CBP-interacting protein; pCIP; Class E basic helix-loop-helix protein 42; bHLHe42; Receptor-associated coactivator
Documentation
Powered by Bioz
