IKBKB - inhibitor of nuclear factor kappa B kinase subunit beta Gene

Also Known as IKK2; IKKB; IMD15; IMD15A; IMD15B; NFKBIKB; IKK-beta

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3551

About IKBKB

Cytogenetic location: 8p11.21 Genomic coordinates (GRCh38): 8:42,271,302-42,332,460 (from NCBI)

This gene has 33 transcripts (splice variants), 198 orthologues, 3 paralogues and is associated with 75 phenotypes. Ubiquitous expression in spleen (RPKM 14.6), lymph node (RPKM 12.4) and 25 other tissues.

Summary

The protein encoded by this gene phosphorylates the inhibitor in the inhibitor/NF-kappa-B complex, causing dissociation of the inhibitor and activation of NF-kappa-B. The encoded protein itself is found in a complex of proteins. Several transcript variants, some protein-coding and some not, have been found for this gene. [provided by RefSeq, Sep 2011]

IKBKB Products (18)

mRNA	Protein	Name
XM_047421758.1	XP_047277714.1	inhibitor of nuclear factor kappa-B kinase subunit beta isoform X3
NR_040009.2
NR_033819.2
XM_011544517.3	XP_011542819.1	inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1
NM_001190721.1
XM_047421757.1	XP_047277713.1	inhibitor of nuclear factor kappa-B kinase subunit beta isoform X2
XM_047421761.1	XP_047277717.1	inhibitor of nuclear factor kappa-B kinase subunit beta isoform X7
NR_033818.2
XM_011544520.3	XP_011542822.1	inhibitor of nuclear factor kappa-B kinase subunit beta isoform X5
XM_047421762.1	XP_047277718.1	inhibitor of nuclear factor kappa-B kinase subunit beta isoform X8
NM_001556.3	NP_001547.1	inhibitor of nuclear factor kappa-B kinase subunit beta isoform 1
NM_001242778.2	NP_001229707.1	inhibitor of nuclear factor kappa-B kinase subunit beta isoform 5
NM_001190720.3	NP_001177649.2	inhibitor of nuclear factor kappa-B kinase subunit beta isoform 2
XM_047421763.1	XP_047277719.1	inhibitor of nuclear factor kappa-B kinase subunit beta isoform X9
NM_001190722.1
XM_047421759.1	XP_047277715.1	inhibitor of nuclear factor kappa-B kinase subunit beta isoform X4
XM_047421760.1	XP_047277716.1	inhibitor of nuclear factor kappa-B kinase subunit beta isoform X6
XM_047421764.1	XP_047277720.1	inhibitor of nuclear factor kappa-B kinase subunit beta isoform X10

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables IkappaB kinase activity	IDA IDA: Inferred from direct assay	9346484	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	16319058	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9520446	GOA
enables protein heterodimerization activity	IDA IDA: Inferred from direct assay	23091055	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	23091055	GOA
enables protein kinase activity	IDA IDA: Inferred from direct assay	20434986	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	12492477	GOA
enables protein serine/threonine kinase activity	EXP EXP: Inferred from Experiment	18692471	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	11297557	GOA
enables scaffold protein binding	IDA IDA: Inferred from direct assay	23776175	GOA
enables transferrin receptor binding	IPI IPI: Inferred from physical interaction	23016877	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	9346484	GOA
involved in canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	15383541	GOA
involved in cellular response to tumor necrosis factor	IDA IDA: Inferred from direct assay	23091055	GOA
involved in cortical actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	25816133	GOA
involved in interleukin-1-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	25816133	GOA
involved in negative regulation of bicellular tight junction assembly	IMP IMP: Inferred from mutant phenotype	25816133	GOA
involved in peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	21399639	GOA
acts upstream of or within positive regulation of NF-kappaB transcription factor activity	IDA IDA: Inferred from direct assay	15790681	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	9346484	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	30337470	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	23091055	GOA
involved in protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	25816133	GOA
involved in protein maturation	IDA IDA: Inferred from direct assay	11297557	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	15084260	GOA
involved in regulation of establishment of endothelial barrier	IMP IMP: Inferred from mutant phenotype	25816133	GOA
involved in regulation of phosphorylation	IDA IDA: Inferred from direct assay	26212789	GOA
involved in tumor necrosis factor-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	12656673	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
part of IkappaB kinase complex	IPI IPI: Inferred from physical interaction	20434986	GOA
is active in cytoplasm	IDA IDA: Inferred from direct assay	9804806	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IKBKB Protein Structure

Pkinase

IKKbetaNEMObind

0
200
400
600
756 a.a.

Protein Preferred Names	Protein Names
inhibitor of nuclear factor kappa-B kinase subunit beta	I-kappa-B kinase 2 I-kappa-B-kinase beta inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta nuclear factor NF-kappa-B inhibitor kinase beta serine/threonine protein kinase IKBKB

IKBKB Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	IKBKB	O14920	TSC1	Homo sapiens	Q92574	Anti Bait CoIP	17693255
Intra	IKBKB	O14920	STAP2	Homo sapiens	Q9UGK3	Anti Bait CoIP	16365431
Intra	IKBKB	O14920	STAP2	Homo sapiens	Q9UGK3	Anti Tag CoIP	16365431
Cross	IKBKB	O14920	N	SARS-CoV-2	P0DTC9	Confocal	33895773
Cross	IKBKB	O14920	N	SARS-CoV-2	P0DTC9	Anti Tag CoIP	33895773
Intra	IKBKB	O14920	CDC37	Homo sapiens	Q16543	Anti Tag CoIP	33961781
Intra	IKBKB	O14920	CDC37	Homo sapiens	Q16543	Anti Tag CoIP	21903422
Intra	IKBKB	O14920	CDC37	Homo sapiens	Q16543	Anti Tag CoIP	35271311
Intra	IKBKB	O14920	NFKB1	Homo sapiens	P19838	PLA	25241761
Intra	IKBKB	O14920	NFKB1	Homo sapiens	P19838	Protein Kinase Assay	12482991
Intra	IKBKB	O14920	NFKBIA	Homo sapiens	P25963	Protein Kinase Assay	22037600
Intra	IKBKB	O14920	NFKBIA	Homo sapiens	P25963	Protein Kinase Assay	16365431
Intra	IKBKB	O14920	NFKBIA	Homo sapiens	P25963	Anti Bait CoIP	19345327
Intra	IKBKB	O14920	NFKBIA	Homo sapiens	P25963	Protein Kinase Assay	16126728
Intra	IKBKB	O14920	NFKBIA	Homo sapiens	P25963	TAP	14743216
Intra	IKBKB	O14920	NFKBIA	Homo sapiens	P25963	Protein Kinase Assay	25759022
Intra	IKBKB	O14920	NFKBIA	Homo sapiens	P25963	Protein Kinase Assay	21765415
Intra	IKBKB	O14920	NFKBIA	Homo sapiens	P25963	Protein Kinase Assay	16319058
Intra	IKBKB	O14920	NFKBIA	Homo sapiens	P25963	Protein Kinase Assay	21399639
Intra	IKBKB	O14920	NFKBIA	Homo sapiens	P25963	Protein Kinase Assay	12486103
Intra	IKBKB	O14920	RPS3	Homo sapiens	P23396	Anti Bait CoIP	21399639
Intra	IKBKB	O14920	RPS3	Homo sapiens	P23396	Protein Kinase Assay	21399639
Intra	IKBKB	O14920	NFKBIB	Homo sapiens	Q15653	TAP	14743216
Intra	IKBKB	O14920	MAP3K14	Homo sapiens	Q99558	Anti Tag CoIP	10733566
Intra	IKBKB	O14920	MAP3K14	Homo sapiens	Q99558	TAP	14743216
Intra	IKBKB	O14920	MAP3K7	Homo sapiens	O43318	Anti Bait CoIP	17363973
Intra	IKBKB	O14920	MAP3K7	Homo sapiens	O43318	Confocal	33895773
Cross	IKBKB	O14920	OPG200	vaccinia virus	P24772	Lumier	18266467
Cross	IKBKB	O14920	Zc3h12a	Mus musculus	Q5D1E7	Protein Kinase Assay	22037600
Cross	IKBKB	O14920	Zc3h12a	Mus musculus	Q5D1E7	Anti Tag CoIP	22037600
Intra	IKBKB	O14920	PPP2CA	Homo sapiens	P67775	CoIP	16129692
Intra	IKBKB	O14920	RELA	Homo sapiens	Q04206	Experimental Interac	10521409
Intra	IKBKB	O14920	RELA	Homo sapiens	Q04206	Protein Kinase Assay	12842894
Intra	IKBKB	O14920	KEAP1	Homo sapiens	Q14145	Pull Down	20600852
Intra	IKBKB	O14920	KEAP1	Homo sapiens	Q14145	Anti Tag CoIP	20600852
Intra	IKBKB	O14920	KEAP1	Homo sapiens	Q14145	Confocal	20600852
Intra	IKBKB	O14920	NCOA3	Homo sapiens	Q9Y6Q9	CoIP	11971985
Intra	IKBKB	O14920	CHUK	Homo sapiens	O15111	TAP	14743216
Intra	IKBKB	O14920	CHUK	Homo sapiens	O15111	Anti Tag CoIP	28514442
Intra	IKBKB	O14920	CHUK	Homo sapiens	O15111	Anti Tag CoIP	33961781
Intra	IKBKB	O14920	CHUK	Homo sapiens	O15111	Anti Tag CoIP	21903422
Intra	IKBKB	O14920	CHUK	Homo sapiens	O15111	Anti Bait CoIP	16286467
Intra	IKBKB	O14920	CHUK	Homo sapiens	O15111	Anti Bait CoIP	12486103
Intra	IKBKB	O14920	CHUK	Homo sapiens	O15111	Anti Tag CoIP	25852190
Intra	IKBKB	O14920	CHUK	Homo sapiens	O15111	Anti Tag CoIP	35271311
Intra	IKBKB	O14920	IKBKG	Homo sapiens	Q9Y6K9	Anti Tag CoIP	25852190
Intra	IKBKB	O14920	IKBKG	Homo sapiens	Q9Y6K9	Anti Tag CoIP	21423167
Intra	IKBKB	O14920	IKBKG	Homo sapiens	Q9Y6K9	Anti Tag CoIP	16319058
Intra	IKBKB	O14920	IKBKG	Homo sapiens	Q9Y6K9	Anti Tag CoIP	21903422
Intra	IKBKB	O14920	IKBKG	Homo sapiens	Q9Y6K9	Anti Tag CoIP	35271311
Intra	IKBKB	O14920	IKBKG	Homo sapiens	Q9Y6K9	Anti Tag CoIP	16129692
Intra	IKBKB	O14920	IKBKG	Homo sapiens	Q9Y6K9	Pull Down	20098747
Intra	IKBKB	O14920	IKBKG	Homo sapiens	Q9Y6K9	Anti Tag CoIP	16126728
Intra	IKBKB	O14920	IKBKG	Homo sapiens	Q9Y6K9	Anti Tag CoIP	9751060
Intra	IKBKB	O14920	IKBKG	Homo sapiens	Q9Y6K9	Anti Tag CoIP	17568778
Intra	IKBKB	O14920	IKBKG	Homo sapiens	Q9Y6K9	Protein Kinase Assay	16319058
Intra	IKBKB	O14920	IKBKG	Homo sapiens	Q9Y6K9	Y2H Array	20211142
Intra	IKBKB	O14920	IKBKG	Homo sapiens	Q9Y6K9	Protein Kinase Assay	16126728
Intra	IKBKB	O14920	IKBKG	Homo sapiens	Q9Y6K9	TAP	14743216
Cross	IKBKB	O14920	Tax	Human T-cell leukemia virus 1	P03409	Anti Tag CoIP	16129692
Cross	IKBKB	O14920	Tax	Human T-cell leukemia virus 1	P03409	Anti Tag CoIP	16126728
Cross	IKBKB	O14920	LMP1	Epstein-Barr virus	P03230	Anti Tag CoIP	18198944

Cross: Cross-species interaction Intra: Intraspecies interaction

IKBKB Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P80719	IKK beta Antibody (YA347)	WB, ICC/IF	Human, Mouse, Rat
HY-P80719A	IKK beta Antibody (YA347)(PBS only)	WB, ICC/IF	Human, Mouse, Rat
HY-P82126	IKK alpha/beta Antibody (YA1871)	WB, ICC/IF, IP	Human, Mouse, Rat
HY-P85217	IKK beta Antibody (YA4909)	WB	Human
HY-P85530	IKK beta Antibody (YA5222)	WB	Human, Rat
HY-P86459	IKK alpha/beta Antibody (YA6151)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
HY-P87500	IKK beta Antibody (YA7184)	WB, ELISA	Human
HY-P87500A	IKK beta Antibody (YA7184)(PBS only)	WB, ELISA	Human

Related Diseases

Diseases	Alias
Ectodermal Dysplasia	Congenital Ectodermal Defect Congenital Ectodermal Dysplasia Ectodermal Dysplasia Syndrome Dysplasia, Ectodermal
Skin Disease	Skin Diseases Abnormality Of The Skin Skin Diseases, Genetic Genodermatosis Skin And Subcutaneous Tissue Disease Dermatologic Disorders
B-Cell Lymphoma	Lymphoma, B-Cell B-Cell Lymphomas B-Cell Lymphocytic Neoplasm Lymphoma B-Cell B-Cell Lymphoma Nos
Immunodeficiency 45	IMD45
Combined Immunodeficiency	Combined T Cell And B Cell Immunodeficiency Congenital Combined Immunodeficiency Syndrome With Combined Immunodeficiency Combined T And B Cell Immunodeficiency Combined Immunity Deficiency Combined Immunodeficiency Syndrome Combined T-Cell And B-Cell Immunodeficiency Lymphopenic Agammaglobulinaemia
Myeloma, Multiple	Multiple Myeloma Kahler Disease Myelomatosis Plasma Cell Myeloma Medullary Plasmacytoma Multiple Myeloma, Resistance To Myeloma Plasma Cell Dyscrasia Multiple Myeloma, Susceptibility To Myeloma - Multiple Kahler'S Disease Kahler-Bozzolo Disease Plasma Cell Myelomas MM Plasma Cell Neoplasm Primary Systemic Amyloidosis Primary Amyloidosis Immunoglobulin Deposition Disease Plasmacytic Myeloma Multiple Myelomata Multiple Myeloma Nos Multiple Myeloma Without Mention Of Remission Monostotic Plasma Cell Myeloma Mm - [Multiple Myeloma]
Hepatitis	Chronic Hepatitis Chronic Persistent Hepatitis Acute Hepatitis Hepatitis, Chronic Acute And Subacute Liver Necrosis Acute/Subac. Necrosis Of Liver Animal Hepatitis Hepatitis Chronic Hepatitis A Hepatitis, Animal Hepatitis Due To Toxoplasmosis Hepatitis In Toxoplasmosis Toxoplasmal Hepatitis Chronic Hepatitis, Unspecified Chronic Active Hepatitis Nec Other Specified Chronic Hepatitis Chronic Persistent Hepatitis Nec Chronic Lobular Hepatitis Nec
Agammaglobulinemia	Hypogammaglobulinemia Ighm Mu Heavy Chain Deficiency Mu-Heavy Chain Disease Mu-Hcd Mu-Chain Disease
T-Cell Acute Lymphoblastic Leukemia	T-Cell Leukemia Acute T Cell Leukemia Precursor T Lymphoblastic Leukemia Precursor T-Lymphoblastic Lymphoma/Leukemia T Acute Lymphoblastic Leukemia T-Cell Acute Lymphocytic Leukaemia T-Cell Lymphoblastic Leukemia/Lymphoma Leukemia T-Cell Leukemia, T-Cell Leukemia, Acute, Lymphoblastic, T-Cell Leukemia, T-Cell Acute Lymphoblastic Leukemia, Acute T-Cell Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Precursor T-Cell Lymphoblastic Lymphoma Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma
Diabetes Mellitus	Diabetes
Severe Combined Immunodeficiency	Scid Severe Combined Immunodeficiency Disease Combined T And B Cell Inborn Immunodeficiency Immunodeficiency, Severe Combined Scid - [Severe Combined Immunodeficiencies]
Incontinentia Pigmenti	Bloch-Sulzberger Syndrome IP Incontinentia Pigmenti, Familial Male-Lethal Type Incontinentia Pigmenti Syndrome Bloch-Siemens Syndrome Ip2 Incontinentia Pigmenti, Type Ii, Formerly Ip2, Formerly Incontinentia Pigmenti Type 2 Bloch-Siemens-Sulzberger Syndrome Familial Incontinentia Pigmenti Male-Lethal Type Familial Incontinentia Pigmenti Type Ii Incontinentia Pigmenti, Type Ii Bloch Sulzberger Syndrome Incontinentia Pigmenti Achromians Incontinentia Pigmenti Of Bloch-Sulzberger Nevus Pigmentosus Systematicus
Oral Candidiasis	Thrush Candidiasis Of Mouth Oral Moniliasis Thrush, Oral Candidiasis, Oral Oral Thrush Candidiasis Equine Thrush
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Obesity , Susceptibility To Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis
Glycogen Storage Disease Iv	Gsd Iv Glycogen Branching Enzyme Deficiency Andersen Disease Amylopectinosis Glycogen Storage Disease Type Iv GSD4 Brancher Deficiency Glycogen Storage Disease, Type Iv Glycogen Storage Disease Due To Glycogen Branching Enzyme Deficiency, Congenital Neuromuscular Form Gbe1 Deficiency Glycogenosis Iv Cirrhosis, Familial, With Deposition Of Abnormal Glycogen Glycogen Storage Disease Type 4 Glycogenosis 4 Potassium-Sensitive Periodic Paralysis, Ventricular Ectopy, And Dysmorphic Features Andersen'S Disease Glycogen Storage Disease Due To Glycogen Branching Enzyme Deficiency, Childhood Neuromuscular Form Glycogen Storage Disease Due To Glycogen Branching Enzyme Deficiency, Fatal Perinatal Neuromuscular Form Brancher Deficiency Glycogenosis Branching-Transferase Deficiency Glycogenosis Deficiency Of 1,4-Alpha-Glucan Branching Enzyme Andersen-Tawil Syndrome Gsd 4 Andersen Cardiodysrhythmic Periodic Paralysis Lqt7 Long Qt Syndrome 7 Periodic Paralysis, Potassium-Sensitive Cardiodysrhythmic Type Andersen Glycogenosis Branching Enzyme Deficiency Glycogenosis, Type Iv Gsd Type Iv Type Iv Glycogenosis Gbe Deficiency, Childhood Neuromuscular Form Gsd Due To Glycogen Branching Enzyme Deficiency, Childhood Neuromuscular Form Gsd Type 4, Childhood Neuromuscular Form Gsdiv, Childhood Neuromuscular Form Glycogen Storage Disease Type 4, Childhood Neuromuscular Form Glycogen Storage Disease Type Iv, Childhood Neuromuscular Form Glycogenosis Due To Glycogen Branching Enzyme Deficiency, Childhood Neuromuscular Form Glycogenosis Type 4, Childhood Neuromuscular Form Glycogenosis Type Iv, Childhood Neuromuscular Form Glycogen Storage Disease Due To Glycogen Branching Enzyme Deficiency, Adult Neuromuscular Form Gbe Deficiency, Adult Neuromuscular Form Gsd Due To Glycogen Branching Enzyme Deficiency, Adult Neuromuscular Form Gsd Type 4, Adult Neuromuscular Form Gsdiv, Adult Neuromuscular Form Glycogen Storage Disease Type 4, Adult Neuromuscular Form Glycogen Storage Disease Type Iv, Adult Neuromuscular Form Glycogenosis Due To Glycogen Branching Enzyme Deficiency, Adult Neuromuscular Form Glycogenosis Type 4, Adult Neuromuscular Form Glycogenosis Type Iv, Adult Neuromuscular Form Gbe Deficiency, Congenital Neuromuscular Form Gsd Due To Glycogen Branching Enzyme Deficiency, Congenital Neuromuscular Form Gsd Type 4, Congenital Neuromuscular Form Gsdiv, Congenital Neuromuscular Form Glycogen Storage Disease Type 4, Congenital Neuromuscular Form Glycogen Storage Disease Type Iv, Congenital Neuromuscular Form Glycogenosis Due To Glycogen Branching Enzyme Deficiency, Congenital Neuromuscular Form Glycogenosis Type 4, Congenital Neuromuscular Form Glycogenosis Type Iv, Congenital Neuromuscular Form Glycogen Storage Disease Due To Glycogen Branching Enzyme Deficiency, Childhood Combined Hepatic And Myopathic Form Gbe Deficiency, Childhood Combined Hepatic And Myopathic Form Gsd Due To Glycogen Branching Enzyme Deficiency, Childhood Combined Hepatic And Myopathic Form Gsd Type 4, Childhood Combined Hepatic And Myopathic Form Gsdiv, Childhood Combined Hepatic And Myopathic Form Glycogen Storage Disease Type 4, Childhood Combined Hepatic And Myopathic Form Glycogen Storage Disease Type Iv, Childhood Combined Hepatic And Myopathic Form Glycogenosis Due To Glycogen Branching Enzyme Deficiency, Childhood Combined Hepatic And Myopathic Form Glycogenosis Type 4, Childhood Combined Hepatic And Myopathic Form Glycogenosis Type Iv, Childhood Combined Hepatic And Myopathic Form Gbe Deficiency, Fatal Perinatal Neuromuscular Form Gsd Due To Glycogen Branching Enzyme Deficiency, Fatal Perinatal Neuromuscular Form Gsd Type 4, Fatal Perinatal Neuromuscular Form Gsdiv, Fatal Perinatal Neuromuscular Form Glycogen Storage Disease Type 4, Fatal Perinatal Neuromuscular Form Glycogen Storage Disease Type Iv, Fatal Perinatal Neuromuscular Form Glycogenosis Due To Glycogen Branching Enzyme Deficiency, Fatal Perinatal Neuromuscular Form Glycogenosis Type 4, Fatal Perinatal Neuromuscular Form Glycogenosis Type Iv, Fatal Perinatal Neuromuscular Form Glycogen Storage Disease Due To Glycogen Branching Enzyme Deficiency, Non Progressive Hepatic Form Gbe Deficiency, Non Progressive Hepatic Form Gsd Due To Glycogen Branching Enzyme Deficiency, Non Progressive Hepatic Form Gsd Type 4, Non Progressive Hepatic Form Gsdiv, Non Progressive Hepatic Form Glycogen Storage Disease Type 4, Non Progressive Hepatic Form Glycogen Storage Disease Type Iv, Non Progressive Hepatic Form Glycogenosis Due To Glycogen Branching Enzyme Deficiency, Non Progressive Hepatic Form Glycogenosis Type 4, Non Progressive Hepatic Form Glycogenosis Type Iv, Non Progressive Hepatic Form Glycogen Storage Disease Due To Glycogen Branching Enzyme Deficiency, Progressive Hepatic Form Gbe Deficiency, Progressive Hepatic Form Gsd Due To Glycogen Branching Enzyme Deficiency, Progressive Hepatic Form Gsd Type 4, Progressive Hepatic Form Gsdiv, Progressive Hepatic Form Glycogen Storage Disease Type 4, Progressive Hepatic Form Glycogen Storage Disease Type Iv, Progressive Hepatic Form Glycogenosis Due To Glycogen Branching Enzyme Deficiency, Progressive Hepatic Form Glycogenosis Type 4, Progressive Hepatic Form Glycogenosis Type Iv, Progressive Hepatic Form Glycogen Storage Disease 4 Gsd-Iv Storage Disease, Glycogen, Type Iv
Osteopetrosis	Albers-Schonberg Disease Marble Bone Disease Osteopetroses Marble Bones Osteopetrosis And Related Disorders Congenital Osteopetrosis Marble Bone Albers-Schoenberg Disease Albers-Schonberg Osteopetrosis Osteosclerosis Fragilis Ivory Bones
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Protection Against Lung Cancer, Susceptibility To Adenocarcinoma Of Lung, Somatic Nonsmall Cell Lung Cancer Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Asbestos-Related Lung Carcinoma
Pancreatic Adenocarcinoma	Adenocarcinoma Of Pancreas Adenocarcinoma Of The Pancreas Pancreas Adenocarcinoma Malignant Exocrine Neoplasm Primary Pancreatic Adenocarcinoma Adenocarcinoma Of Islet Cell Of Pancreas Islet Cell Adenocarcinoma Of Unspecified Site Mixed Adenocarcinoma Islet Cell With Exocrine Of Unspecified Site
Immunodeficiency 15a	IMD15A
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Severe Combined Immunodeficiency Due To Ikk2 Deficiency	Scid Due To Ikk2 Deficiency
Ectodermal Dysplasia 10b, Hypohidrotic/Hair/Tooth Type, Autosomal Recessive	Hypohidrotic Ectodermal Dysplasia Hed Anhidrotic Ectodermal Dysplasia Ectodermal Dysplasia, Hypohidrotic Eda Christ-Siemens-Touraine Syndrome ECTD10B Ectodermal Dysplasia Anhidrotic Ectodermal Dysplasia, Anhidrotic Cst Syndrome Ectodermal Dysplasia Hypohidrotic Autosomal Recessive Dysplasia, Ectodermal, Type 10b, Hypohidrotic/Hair/Tooth, Autosomal Recessive Dysplasia, Ectodermal, Hypohidrotic Ectodermal Dysplasia 11b, Hypohidrotic/Hair/Tooth Type, Autosomal Recessive Ectodermal Dysplasia 3, Anhidrotic Ectodermal Dysplasia, Hypohidrotic, Autosomal Recessive
Endometrial Cancer	Endometrial Carcinoma Endometrial Neoplasm Malignant Neoplasm Of Endometrium Endometrioid Carcinoma Endometrial Neoplasms Carcinoma, Endometrioid Endometrial Cancer, Familial Endometrial Carcinoma, Somatic Endometrial Cancer, Susceptibility To Endometrial Ca Malignant Endometrial Neoplasm Neoplasm Of Endometrium Primary Malignant Neoplasm Of Endometrium Tumor Of Endometrium Carcinoma Of The Endometrium Endometrioid Carcinoma Of Female Reproductive System ENDMC Carcinoma Endometrioid Endometrial Cancers Cancer, Endometrial Uterine Corpus Cancer
Immunodeficiency 15b	IMD15B Immunodeficiency, Type 15b
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Diabetes Mellitus, Non-Insulin-Dependent Type 2 Diabetes T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS06659	Ikbkb Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS06658	IKBKB Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS06660	Ikbkb Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	IKBKB	RGD	RGD:621375
Macaca mulatta	IKBKB	VGNC	VGNC:84006
Mus musculus	IKBKB	MGD	MGI:1338071
Bos taurus	IKBKB	VGNC	VGNC:106778
Felis catus	IKBKB	VGNC	VGNC:78515
Canis familiaris	IKBKB	VGNC	VGNC:51803
Others	IKBKB	NCBI