MAP3K14 - mitogen-activated protein kinase kinase kinase 14 Gene
Also Known as HS; NIK; HSNIK; FTDCR1B
Species: Homo sapiens
About MAP3K14
This gene has 6 transcripts (splice variants), 1 gene allele, 241 orthologues, 35 paralogues and is associated with 1 phenotype. Ubiquitous expression in lymph node (RPKM 11.1), spleen (RPKM 8.5) and 25 other tissues.
Summary
This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several Other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor. [provided by RefSeq, Jul 2008]
MAP3K14 Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_003954.5 | NP_003945.2 | mitogen-activated protein kinase kinase kinase 14 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
9020361 | GOA |
| enables protein kinase activity |
IDA
IDA: Inferred from direct assay
|
15001576 | GOA |
| enables protein serine/threonine kinase activity |
EXP
EXP: Inferred from Experiment
|
9520446 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in cellular response to mechanical stimulus |
IEP
IEP: Inferred from expression pattern
|
19593445 | GOA |
| involved in defense response to virus |
IDA
IDA: Inferred from direct assay
|
21478870 | GOA |
| involved in non-canonical NF-kappaB signal transduction |
IMP
IMP: Inferred from mutant phenotype
|
10094049 | GOA |
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
mitogen-activated protein kinase kinase kinase 14 |
|
MAP3K14 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
MAP3K14 | Q99558 | RPS11 | Homo sapiens | P62280 | 31980649 | |
|
Intra
|
MAP3K14 | Q99558 | KPNB1 | Homo sapiens | Q14974 | 30833792 | |
|
Intra
|
MAP3K14 | Q99558 | CDC37 | Homo sapiens | Q16543 | 25036637 | |
|
Intra
|
MAP3K14 | Q99558 | CDC37 | Homo sapiens | Q16543 | 30833792 | |
|
Intra
|
MAP3K14 | Q99558 | CDC37 | Homo sapiens | Q16543 | 31980649 | |
|
Intra
|
MAP3K14 | Q99558 | CDC37 | Homo sapiens | Q16543 | 32707033 | |
|
Intra
|
MAP3K14 | Q99558 | HSP90AA1 | Homo sapiens | P07900 | 31980649 | |
|
Intra
|
MAP3K14 | Q99558 | HSP90AA1 | Homo sapiens | P07900 | 30833792 | |
|
Intra
|
MAP3K14 | Q99558 | HSP90AA1 | Homo sapiens | P07900 | 32707033 | |
|
Intra
|
MAP3K14 | Q99558 | RPL4 | Homo sapiens | P36578 | 31980649 | |
|
Intra
|
MAP3K14 | Q99558 | HRAS | Homo sapiens | P01112 | 32814053 | |
|
Intra
|
MAP3K14 | Q99558 | HRAS | Homo sapiens | P01112 | 32814053 | |
|
Intra
|
MAP3K14 | Q99558 | HRAS | Homo sapiens | P01112 | 32814053 | |
|
Intra
|
MAP3K14 | Q99558 | RPS13 | Homo sapiens | P62277 | 31980649 | |
|
Intra
|
MAP3K14 | Q99558 | HSP90AB1 | Homo sapiens | P08238 | 32707033 | |
|
Intra
|
MAP3K14 | Q99558 | HSP90AB1 | Homo sapiens | P08238 | 22939624 | |
|
Intra
|
MAP3K14 | Q99558 | HSP90AB1 | Homo sapiens | P08238 | 31980649 | |
|
Intra
|
MAP3K14 | Q99558 | TRAF2 | Homo sapiens | Q12933 | 31980649 | |
|
Intra
|
MAP3K14 | Q99558 | TRAF2 | Homo sapiens | Q12933 | 9020361 | |
|
Intra
|
MAP3K14 | Q99558 | TRAF2 | Homo sapiens | Q12933 | 25416956 | |
|
Intra
|
MAP3K14 | Q99558 | TRAF2 | Homo sapiens | Q12933 | 25416956 | |
|
Intra
|
MAP3K14 | Q99558 | TRAF3 | Homo sapiens | Q13114 | 32296183 | |
|
Intra
|
MAP3K14 | Q99558 | TRAF3 | Homo sapiens | Q13114 | 31980649 | |
|
Intra
|
MAP3K14 | Q99558 | TRAF3 | Homo sapiens | Q13114 | 32296183 | |
|
Intra
|
MAP3K14 | Q99558 | TRAF3 | Homo sapiens | Q13114 | 33961781 | |
|
Intra
|
MAP3K14 | Q99558 | TRAF3 | Homo sapiens | Q13114 | 28514442 | |
|
Intra
|
MAP3K14 | Q99558 | TRAF3 | Homo sapiens | Q13114 | 32707033 | |
|
Intra
|
MAP3K14 | Q99558 | TRAF3 | Homo sapiens | Q13114 | 30833792 | |
|
Intra
|
MAP3K14 | Q99558 | RPL6 | Homo sapiens | Q02878 | 31980649 | |
|
Intra
|
MAP3K14 | Q99558 | RPL8 | Homo sapiens | P62917 | 31980649 | |
|
Intra
|
MAP3K14 | Q99558 | CHUK | Homo sapiens | O15111 | 30833792 | |
|
Intra
|
MAP3K14 | Q99558 | CHUK | Homo sapiens | O15111 | 32707033 | |
|
Intra
|
MAP3K14 | Q99558 | CHUK | Homo sapiens | O15111 | 9520446 | |
|
Intra
|
MAP3K14 | Q99558 | CHUK | Homo sapiens | O15111 | 16498412 | |
|
Intra
|
MAP3K14 | Q99558 | CHUK | Homo sapiens | O15111 | 33961781 | |
|
Intra
|
MAP3K14 | Q99558 | CHUK | Homo sapiens | O15111 | 28514442 | |
|
Intra
|
MAP3K14 | Q99558 | CHUK | Homo sapiens | O15111 | 31980649 | |
|
Intra
|
MAP3K14 | Q99558 | IKBKB | Homo sapiens | O14920 | 33961781 | |
|
Intra
|
MAP3K14 | Q99558 | IKBKB | Homo sapiens | O14920 | 30833792 | |
|
Intra
|
MAP3K14 | Q99558 | IKBKB | Homo sapiens | O14920 | 28514442 | |
|
Intra
|
MAP3K14 | Q99558 | IKBKB | Homo sapiens | O14920 | 32707033 | |
|
Intra
|
MAP3K14 | Q99558 | IKBKB | Homo sapiens | O14920 | 9520446 | |
|
Intra
|
MAP3K14 | Q99558 | IKBKG | Homo sapiens | Q9Y6K9 | 31980649 | |
|
Intra
|
MAP3K14 | Q99558 | IKBKG | Homo sapiens | Q9Y6K9 | 33961781 | |
|
Intra
|
MAP3K14 | Q99558 | IKBKG | Homo sapiens | Q9Y6K9 | 32707033 |
MAP3K14 Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P84750 | MAP3K14 Antibody (YA4447) | IHC-P, FC, ELISA | Human |
| HY-P84750A | MAP3K14 Antibody (YA4447)(PBS only) | IHC-P, FC, ELISA | Human |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Nik Deficiency |
|
|
| Pancreatic Ductal Adenocarcinoma |
|
|
| Immunodeficiency 50 |
|
|
| Pancreatic Adenosquamous Carcinoma |
|
|
| T-Cell Acute Lymphoblastic Leukemia |
|
|
| Ectodermal Dysplasia |
|
|
| Noonan Syndrome 1 |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Rattus norvegicus | MAP3K14 | RGD | RGD:1310487 |
| Bos taurus | MAP3K14 | VGNC | VGNC:31192 |
| Felis catus | MAP3K14 | VGNC | VGNC:99219 |
| Mus musculus | MAP3K14 | MGD | MGI:1858204 |
| Macaca mulatta | MAP3K14 | VGNC | VGNC:81459 |
| Canis familiaris | MAP3K14 | VGNC | VGNC:42970 |
| Others | MAP3K14 | NCBI |