1. Gene
  2. MAP3K14 - mitogen-activated protein kinase kinase kinase 14 Gene

MAP3K14 - mitogen-activated protein kinase kinase kinase 14 Gene

Homo sapiens

Also known as HS; NIK; HSNIK; FTDCR1B

Gene ID: 9020 | Gene type: protein coding

About MAP3K14

Cytogenetic location: 17q21.31 Genomic coordinates (GRCh38): 17:45,263,119-45,317,020 (from NCBI)

This gene has 6 transcripts (splice variants), 1 gene allele, 241 orthologues, 35 paralogues and is associated with 1 phenotype. Ubiquitous expression in lymph node (RPKM 11.1), spleen (RPKM 8.5) and 25 other tissues.

Summary

This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor. [provided by RefSeq, Jul 2008]

MAP3K14 Products(1)

mRNA Protein Name
NM_003954.5 NP_003945.2 mitogen-activated protein kinase kinase kinase 14
Protein Preferred Names Protein Names

mitogen-activated protein kinase kinase kinase 14

NF-kappa-beta-inducing kinase

Related Diseases

Diseases Alias
Nik Deficiency

Primary Immunodeficiency With Multifaceted Aberrant Lymphoid Immunity

Pancreatic Ductal Adenocarcinoma

Ductal Adenocarcinoma Of The Pancreas

Immunodeficiency 50

Combined Immunodeficiency Due To Moesin Deficiency

IMD50

Immunodeficiency 50, X-Linked Recessive

Cid Due To Moesin Deficiency

Msn-Related Combined Immunodeficiency

X-Linked Moesin-Associated Immunodeficiency

Immunodeficiency 50 X Linked Recessive

Pancreatic Adenosquamous Carcinoma

Adenosquamous Carcinoma Of Pancreas

Adenosquamous Carcinoma Of The Pancreas

T-Cell Acute Lymphoblastic Leukemia

T-Cell Leukemia

Acute T Cell Leukemia

Precursor T Lymphoblastic Leukemia

Precursor T-Lymphoblastic Lymphoma/Leukemia

T Acute Lymphoblastic Leukemia

T-Cell Acute Lymphocytic Leukaemia

T-Cell Lymphoblastic Leukemia/Lymphoma

Leukemia T-Cell

Leukemia, T-Cell

Leukemia, Acute, Lymphoblastic, T-Cell

Leukemia, T-Cell Acute Lymphoblastic

Leukemia, Acute T-Cell

Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

Precursor T-Cell Lymphoblastic Lymphoma

Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma

Ectodermal Dysplasia

Congenital Ectodermal Defect

Congenital Ectodermal Dysplasia

Ectodermal Dysplasia Syndrome

Dysplasia, Ectodermal

Noonan Syndrome 1

Noonan Syndrome

NS1

Male Turner Syndrome

Female Pseudo-Turner Syndrome

Turner Phenotype With Normal Karyotype

Noonan Syndrome With Pigmented Villonodular Synovitis

Turner'S Phenotype, Karyotype Normal

Familial Turner Syndrome

Noonan'S Syndrome

Noonan-Ehmke Syndrome

Ns

Pseudo-Ullrich-Turner Syndrome

Turner Syndrome In Female With X Chromosome

Turner-Like Syndrome

Ullrich-Noonan Syndrome

Noonan-Like/Multiple Giant Cell Lesion Syndrome

Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions

Pterygium Colli Syndrome

Noonan Syndrome, Type 1

Turner Syndrome, Male

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Rattus norvegicus MAP3K14 RGD RGD:1310487
Bos taurus MAP3K14 VGNC VGNC:31192
Felis catus MAP3K14 VGNC VGNC:99219
Mus musculus MAP3K14 MGD MGI:1858204
Macaca mulatta MAP3K14 VGNC VGNC:81459
Canis familiaris MAP3K14 VGNC VGNC:42970