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RPL8 - ribosomal protein L8 Gene

Also Known as L8

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6132

About RPL8

Cytogenetic location: 8q24.3 Genomic coordinates (GRCh38): 8:144,789,769-144,792,390 (from NCBI)

This gene has 14 transcripts (splice variants), 233 orthologues and 1 paralogue. Ubiquitous expression in ovary (RPKM 817.1), colon (RPKM 466.9) and 25 other tissues.

Summary

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L2P family of ribosomal proteins. It is located in the cytoplasm. In rat, the protein associates with the 5.8S rRNA, very likely participates in the binding of aminoacyl-tRNA, and is a constituent of the elongation factor 2-binding site at the ribosomal subunit interface. Alternatively spliced transcript variants encoding the same protein exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

RPL8 Products (4)

mRNA	Protein	Name
NM_000973.5	NP_000964.1	60S ribosomal protein L8
NM_001317771.2	NP_001304700.1	60S ribosomal protein L8
NM_001317782.2	NP_001304711.1	60S ribosomal protein L8
NM_033301.3	NP_150644.1	60S ribosomal protein L8

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14743216	GOA
enables structural constituent of ribosome	IDA IDA: Inferred from direct assay	23636399	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cytoplasmic translation	IDA IDA: Inferred from direct assay	25957688	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of cytosolic large ribosomal subunit	IDA IDA: Inferred from direct assay	25957688	GOA
part of cytosolic large ribosomal subunit	IPI IPI: Inferred from physical interaction	25901680	GOA
located in cytosolic ribosome	IDA IDA: Inferred from direct assay	23636399	GOA
is active in postsynapse	EXP EXP: Inferred from Experiment	23071613	GOA
is active in postsynapse	IDA IDA: Inferred from direct assay	23071613	GOA
is active in postsynaptic density	EXP EXP: Inferred from Experiment	21170055	GOA
is active in postsynaptic density	IDA IDA: Inferred from direct assay	21170055	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RPL8 Protein Structure

Ribosomal_L2

Ribosomal_L2_C

0
100
200
257 a.a.

Protein Preferred Names	Protein Names
60S ribosomal protein L8	large ribosomal subunit protein uL2

RPL8 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RPL8	P62917	MAP3K14	Homo sapiens	Q99558	TAP	14743216

Cross: Cross-species interaction Intra: Intraspecies interaction

RPL8 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P811255	RPL8 Antibody	WB, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Spermatogenic Failure 2	SPGF2 Aspermiogenesis Factor Asg
Spermatogenic Failure 1	Oligosynaptic Infertility SPGF1 Oligochiasmatic Infertility Oligochiasmic Infertility
Diamond-Blackfan Anemia	Congenital Pure Red Cell Aplasia Aase Syndrome Erythrogenesis Imperfecta Anemia, Diamond-Blackfan Congenital Hypoplastic Anemia Aase-Smith Ii Syndrome Bds Blackfan-Diamond Anemia Congenital Prca Congenital Hypoplastic Anemia, Blackfan-Diamond Type Dba Blackfan - Diamond Syndrome Chronic Constitutional Pure Red Cell Anaemia Anemia Diamond Blackfan Type Anemia Congenital Erythroid Hypoplastic Aregenerative Anemia Chronic Congenital Blackfan Diamond Syndrome Red Cell Aplasia, Pure Hereditary Aase-Smith Syndrome Ii Bda Blackfan Diamond Anemia Blackfan-Diamond Disease Blackfan-Diamond Syndrome Chronic Congenital Agenerative Anemia Congenital Erythroid Hypoplastic Anemia Congenital Hypoplastic Anemia Of Blackfan And Diamond Congenital Pure Red Cell Anemia Hypoplastic Congenital Anemia Inherited Erythroblastopenia Pure Hereditary Red Cell Aplasia Anemia, Hypoplastic, Congenital Anemia Hypoplastic Congenital Fanconi Anemia Constitutional Aplastic Anemia Diamond-Blackfan Anemia 1 Aase Smith Syndrome 2 Congenital Red Cell Aplasia Red Cell Aplasia Of Infants Pure Red Cell Aplasia Of Infants Congenital Red Cell Aplastic Anaemia Congenital Pure Red Cell Anaemia Congenital Erythroid Hypoplasia Pearson Marrow-Pancreas Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12205	RPL8 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19948	Rpl8 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26450	Rpl8 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	RPL8	RGD	RGD:619827
Macaca mulatta	RPL8	VGNC	VGNC:84110
Canis familiaris	RPL8	VGNC	VGNC:45720
Felis catus	RPL8	VGNC	VGNC:64740
Mus musculus	RPL8	MGD	MGI:1350927
Others	RPL8	NCBI