Zc3h12a - zinc finger CCCH type containing 12A Gene

Also Known as Reg1; MCPIP; Mcpip1; MCPIP-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 230738

Summary

Enables RNA binding activity; ribonuclease activity; and ribosome binding activity. Involved in several processes, including cellular response to cytokine stimulus; negative regulation of gene expression; and negative regulation of intracellular signal transduction. Located in nucleus and rough endoplasmic reticulum. Is extrinsic component of endoplasmic reticulum membrane. Used to study primary biliary cholangitis. Human ortholog(s) of this gene implicated in hepatitis B. Orthologous to human ZC3H12A (zinc finger CCCH-type containing 12A). [provided by Alliance of Genome Resources, Apr 2022]

Zc3h12a Products (1)

mRNA Protein Name
NM_153159.2 NP_694799.1 endoribonuclease ZC3H12A

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA endonuclease activity IDA
IDA: Inferred from direct assay
22055188 MGI
enables RNA exonuclease activity IDA
IDA: Inferred from direct assay
19322177 MGI
enables RNA stem-loop binding IDA
IDA: Inferred from direct assay
23185455 MGI
enables mRNA 3'-UTR AU-rich region binding IDA
IDA: Inferred from direct assay
19322177 MGI
enables mRNA 3'-UTR binding IDA
IDA: Inferred from direct assay
23185455 MGI
enables mRNA binding EXP
EXP: Inferred from Experiment
26927947 MGI
enables nuclease activity IMP
IMP: Inferred from mutant phenotype
25282160 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
22037600 MGI
enables ribosome binding IDA
IDA: Inferred from direct assay
26255671 MGI
Biological Process GO Annotation Evidence References Source
involved in 3'-UTR-mediated mRNA destabilization IDA
IDA: Inferred from direct assay
19322177 MGI
involved in T cell receptor signaling pathway IDA
IDA: Inferred from direct assay
23185455 MGI
involved in T cell receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
25282160 MGI
involved in cellular response to chemokine IDA
IDA: Inferred from direct assay
19666473 MGI
involved in cellular response to glucose starvation IDA
IDA: Inferred from direct assay
21971051 MGI
involved in cellular response to ionomycin IDA
IDA: Inferred from direct assay
23185455 MGI
involved in cellular response to lipopolysaccharide IDA
IDA: Inferred from direct assay
19322177 MGI
involved in cellular response to oxidative stress IDA
IDA: Inferred from direct assay
21971051 MGI
involved in cellular response to sodium arsenite IDA
IDA: Inferred from direct assay
21971051 MGI
involved in mRNA catabolic process IDA
IDA: Inferred from direct assay
26000482 MGI
involved in negative regulation of T-helper 17 cell differentiation IMP
IMP: Inferred from mutant phenotype
25282160 MGI
involved in negative regulation of canonical NF-kappaB signal transduction IDA
IDA: Inferred from direct assay
21616078 MGI
involved in negative regulation of cardiac muscle contraction IDA
IDA: Inferred from direct assay
21616078 MGI
involved in negative regulation of cytokine production involved in inflammatory response IDA
IDA: Inferred from direct assay
21616078 MGI
involved in negative regulation of gene expression IMP
IMP: Inferred from mutant phenotype
18178554 MGI
involved in negative regulation of interleukin-1 beta production IDA
IDA: Inferred from direct assay
21616078 MGI
involved in negative regulation of interleukin-6 production IDA
IDA: Inferred from direct assay
21616078 MGI
involved in negative regulation of muscle cell apoptotic process IDA
IDA: Inferred from direct assay
21616078 MGI
involved in negative regulation of nitric oxide biosynthetic process IDA
IDA: Inferred from direct assay
21616078 MGI
involved in negative regulation of non-canonical NF-kappaB signal transduction IDA
IDA: Inferred from direct assay
21616078 MGI
involved in negative regulation of protein phosphorylation IDA
IDA: Inferred from direct assay
21971051 MGI
involved in negative regulation of tumor necrosis factor production IDA
IDA: Inferred from direct assay
21616078 MGI
involved in negative regulation of type II interferon production IDA
IDA: Inferred from direct assay
21616078 MGI
involved in positive regulation of autophagy IMP
IMP: Inferred from mutant phenotype
22739135 MGI
involved in positive regulation of execution phase of apoptosis IDA
IDA: Inferred from direct assay
21971051 MGI
involved in positive regulation of fat cell differentiation IDA
IDA: Inferred from direct assay
19666473 MGI
involved in positive regulation of lipid storage IMP
IMP: Inferred from mutant phenotype
22739135 MGI
involved in positive regulation of mRNA catabolic process IDA
IDA: Inferred from direct assay
19322177 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
19666473 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
19322177 MGI
located in nucleus IDA
IDA: Inferred from direct assay
16574901 MGI
located in rough endoplasmic reticulum IDA
IDA: Inferred from direct assay
26255671 MGI
located in rough endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
26000482 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

endoribonuclease ZC3H12A

  • MCP-1 treatment-induced protein

  • MCP-induced protein 1

  • bifunctional endoribonuclease and deubiquitinase ZC3H12A

  • monocyte chemotactic protein-induced protein 1

  • regnase-1

  • ribonuclease ZC3H12A

  • zinc finger CCCH domain-containing protein 12A

Zc3h12a Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Zc3h12a Q5D1E7 IKBKB Homo sapiens O14920
Anti Tag CoIP
22037600
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15986 ZC3H12A Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Zc3h12a NCBI NCBI:80149