MAP3K7 - mitogen-activated protein kinase kinase kinase 7 Gene

Also Known as CSCF; FMD2; TAK1; MEKK7; TGF1a

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6885

About MAP3K7

Cytogenetic location: 6q15 Genomic coordinates (GRCh38): 6:90,513,579-90,587,072 (from NCBI)

This gene has 24 transcripts (splice variants), 208 orthologues, 2 paralogues and is associated with 5 phenotypes. Ubiquitous expression in thyroid (RPKM 10.0), endometrium (RPKM 9.4) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and Apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

MAP3K7 Products (5)

mRNA	Protein	Name
NM_003188.4	NP_003179.1	mitogen-activated protein kinase kinase kinase 7 isoform A
NM_145332.3	NP_663305.1	mitogen-activated protein kinase kinase kinase 7 isoform C
XM_006715553.4	XP_006715616.1	mitogen-activated protein kinase kinase kinase 7 isoform X1
NM_145333.3	NP_663306.1	mitogen-activated protein kinase kinase kinase 7 isoform D
NM_145331.3	NP_663304.1	mitogen-activated protein kinase kinase kinase 7 isoform B

MAP3K7 Protein Structure

Pkinase_Tyr

0
100
200
300
400
500
606 a.a.

Protein Preferred Names	Protein Names
mitogen-activated protein kinase kinase kinase 7	TGF-beta activated kinase 1 transforming growth factor-beta-activated kinase 1

MAP3K7 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	MAP3K7	O43318	N	SARS-CoV-2	P0DTC9	Anti Tag CoIP	33895773
Intra	MAP3K7	O43318	CDC37	Homo sapiens	Q16543	Pull Down	32707033
Intra	MAP3K7	O43318	CDC37	Homo sapiens	Q16543	Anti Tag CoIP	31980649
Intra	MAP3K7	O43318	UBC	Homo sapiens	P0CG48	Anti Tag CoIP	19820695
Intra	MAP3K7	O43318	TAB1	Homo sapiens	Q15750	Anti Tag CoIP	35271311
Intra	MAP3K7	O43318	TAB1	Homo sapiens	Q15750	Y2H	22158122
Intra	MAP3K7	O43318	TAB1	Homo sapiens	Q15750	Anti Bait CoIP	22158122
Intra	MAP3K7	O43318	TAB1	Homo sapiens	Q15750	PLA	25241761
Intra	MAP3K7	O43318	TAB1	Homo sapiens	Q15750	Pull Down	32707033
Intra	MAP3K7	O43318	TAB2	Homo sapiens	Q9NYJ8	Pull Down	32707033
Intra	MAP3K7	O43318	TAB2	Homo sapiens	Q9NYJ8	Anti Bait CoIP	22081109
Intra	MAP3K7	O43318	TAB2	Homo sapiens	Q9NYJ8	Anti Bait CoIP	16845370
Intra	MAP3K7	O43318	TAB2	Homo sapiens	Q9NYJ8	Anti Tag CoIP	35271311
Intra	MAP3K7	O43318	TAB2	Homo sapiens	Q9NYJ8	Anti Bait CoIP	17158449
Intra	MAP3K7	O43318	TAB2	Homo sapiens	Q9NYJ8	Anti Bait CoIP	22158122
Intra	MAP3K7	O43318	TRAF6	Homo sapiens	Q9Y4K3	Anti Tag CoIP	19820695
Intra	MAP3K7	O43318	PPP6C	Homo sapiens	O00743	Phosphatase Assay	17079228
Intra	MAP3K7	O43318	PPP6C	Homo sapiens	O00743	Anti Tag CoIP	17079228
Intra	MAP3K7	O43318	TAB3	Homo sapiens	Q8N5C8	Pull Down	32707033
Intra	MAP3K7	O43318	TAB3	Homo sapiens	Q8N5C8	Anti Tag CoIP	35271311
Intra	MAP3K7	O43318	MAP2K7	Homo sapiens	O14733	Anti Tag CoIP	17110930
Intra	MAP3K7	O43318	MAP2K7	Homo sapiens	O14733	GMS	17709393
Intra	MAP3K7	O43318	STAT3	Homo sapiens	P40763	Anti Bait CoIP	15764709
Intra	MAP3K7	O43318	MAPK8IP1	Homo sapiens	Q9UQF2	Anti Bait CoIP	17709393
Intra	MAP3K7	O43318	MAPK8IP1	Homo sapiens	Q9UQF2	Pull Down	16840345
Intra	MAP3K7	O43318	IKBKB	Homo sapiens	O14920	Confocal	33895773
Intra	MAP3K7	O43318	IKBKB	Homo sapiens	O14920	Anti Tag CoIP	33895773
Cross	MAP3K7	O43318	cagA	Helicobacter pylori	B5Z6S0	Pull Down	19820695
Cross	MAP3K7	O43318	cagA	Helicobacter pylori	B5Z6S0	Anti Tag CoIP	19820695

Cross: Cross-species interaction Intra: Intraspecies interaction

MAP3K7 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80355	TAK1 Antibody (YA042)	WB	Human, Mouse, Rat, Monkey
HY-P80858	Phospho-TAK1 (Ser439) Antibody (YA144)	WB, ICC/IF, IP	Human, Mouse, Rat
HY-P80858A	Phospho-TAK1 (Ser439) Antibody (YA144)(PBS only)	WB, ICC/IF, IP	Human, Mouse, Rat
HY-P80908	TAK1 Antibody (YA663)	WB	Human, Mouse, Rat, Monkey
HY-P80908A	TAK1 Antibody (YA663)(PBS only)	WB	Human, Mouse, Rat, Monkey
HY-P810681	Phospho-TAK1 (Ser412) Antibody (YA9939)	WB, FC	Human, Mouse, Rat
HY-P86498	TAK1 Antibody (YA6190)	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Noonan Syndrome 1	Noonan Syndrome NS1 Male Turner Syndrome Female Pseudo-Turner Syndrome Turner Phenotype With Normal Karyotype Noonan Syndrome With Pigmented Villonodular Synovitis Turner'S Phenotype, Karyotype Normal Familial Turner Syndrome Noonan'S Syndrome Noonan-Ehmke Syndrome Ns Pseudo-Ullrich-Turner Syndrome Turner Syndrome In Female With X Chromosome Turner-Like Syndrome Ullrich-Noonan Syndrome Noonan-Like/Multiple Giant Cell Lesion Syndrome Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions Pterygium Colli Syndrome Noonan Syndrome, Type 1 Turner Syndrome, Male
Otopalatodigital Syndrome Spectrum Disorder	Opd Spectrum Disorder Opsd Fronto-Otopalatodigital Osteodysplasia
Frontometaphyseal Dysplasia 2	FMD2
Ectodermal Dysplasia	Congenital Ectodermal Defect Congenital Ectodermal Dysplasia Ectodermal Dysplasia Syndrome Dysplasia, Ectodermal
Synostosis
Brachydactyly
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Cardiospondylocarpofacial Syndrome	Mitral Regurgitation, Conductive Deafness, And Fusion Of Cervical Vertebrae And Of Carpal And Tarsal Bones Forney Robinson Pascoe Syndrome CSCF Mitral Regurgitation, Conductive Deafness, And Fusion Of Cervical Vertebrae And Congenital Heart Disease, Deafness, And Skeletal Malformations Forney Syndrome Forney-Robinson-Pascoe Syndrome Mitral Regurgitation-Deafness-Skeletal Anomalies Syndrome Mitral Regurgitation-Hearing Loss-Skeletal Anomalies Syndrome
Frontometaphyseal Dysplasia	Fmd Dysplasia, Frontometaphyseal
Hyperostosis	Hypertrophy Of Bone Bone Hypertrophy Bone Thickening Periosteum Thickening
Non-Syndromic X-Linked Intellectual Disability 91	Mrx91

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-136848	SM1-71	Inhibitor	96.09%	Unkown
HY-RS08062	MAP3K7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS08063	Map3k7 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS08064	MAP3K7 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS08065	MAP3K7CL Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MAP3K7	MGD	MGI:1346877
Rattus norvegicus	MAP3K7	RGD	RGD:1309438
Bos taurus	MAP3K7	VGNC	VGNC:31200
Macaca mulatta	MAP3K7	VGNC	VGNC:74497
Canis familiaris	MAP3K7	VGNC	VGNC:42977
Felis catus	MAP3K7	VGNC	VGNC:68161
Others	MAP3K7	NCBI