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TAB1 - TGF-beta activated kinase 1 (MAP3K7) binding protein 1 Gene

Also Known as 3'-Tab1; MAP3K7IP1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10454

About TAB1

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:39,399,780-39,437,132 (from NCBI)

This gene has 7 transcripts (splice variants), 201 orthologues and 16 paralogues. Ubiquitous expression in ovary (RPKM 7.9), brain (RPKM 7.3) and 25 other tissues.

Summary

The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

TAB1 Products (2)

mRNA	Protein	Name
NM_006116.3	NP_006107.1	TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform alpha
NM_153497.3	NP_705717.1	TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform beta

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables molecular adaptor activity	IDA IDA: Inferred from direct assay	16260783	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10094049	GOA
enables protein serine/threonine kinase activator activity	IDA IDA: Inferred from direct assay	37832545	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in non-canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	16260783	GOA
involved in positive regulation of cGAS/STING signaling pathway	IDA IDA: Inferred from direct assay	37832545	GOA
involved in positive regulation of protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	11865055	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in cytoplasm	IDA IDA: Inferred from direct assay	34017102	GOA
is active in endoplasmic reticulum	IDA IDA: Inferred from direct assay	37832545	GOA
is active in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	37832545	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TAB1 Protein Structure

PP2C

0
100
200
300
400
504 a.a.

Protein Preferred Names	Protein Names
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1	TAK1-binding protein 1

TAB1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TAB1	Q15750	YWHAE	Homo sapiens	P62258	Crosslink	36931259
Intra	TAB1	Q15750	MAP3K7	Homo sapiens	O43318	Anti Tag CoIP	33961781
Intra	TAB1	Q15750	MAP3K7	Homo sapiens	O43318	Anti Tag CoIP	27880917
Intra	TAB1	Q15750	MAP3K7	Homo sapiens	O43318	Anti Tag CoIP	16845370
Intra	TAB1	Q15750	MAP3K7	Homo sapiens	O43318-2	TAP	14743216
Intra	TAB1	Q15750	TAB2	Homo sapiens	Q9NYJ8	Anti Bait CoIP	16845370
Intra	TAB1	Q15750	TAB2	Homo sapiens	Q9NYJ8	Anti Tag CoIP	27880917
Intra	TAB1	Q15750	TAB2	Homo sapiens	Q9NYJ8	Anti Tag CoIP	33961781
Intra	TAB1	Q15750	TAB2	Homo sapiens	Q9NYJ8	Anti Tag CoIP	25260751
Intra	TAB1	Q15750	TAB2	Homo sapiens	Q9NYJ8	TAP	14743216
Intra	TAB1	Q15750	XIAP	Homo sapiens	P98170	BFG-2H	27107012
Intra	TAB1	Q15750	XIAP	Homo sapiens	P98170	Validated Y2H	27107012
Intra	TAB1	Q15750	XIAP	Homo sapiens	P98170	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

TAB1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82206	TAB1 Antibody (YA1951)	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat
HY-P85471	TAB1 Antibody (YA5163)	WB	Human, Mouse, Rat, Bovine, Dog, Pig
HY-P85540	TAB1(N-term) Antibody (YA5232)	WB	Human

Related Diseases

Diseases	Alias
Ectodermal Dysplasia 10a, Hypohidrotic/Hair/Nail Type, Autosomal Dominant	ECTD10A Hed Ectodermal Dysplasia 10a Ectodermal Dysplasia Hypohidrotic Autosomal Dominant Autosomal Dominant Hypohidrotic Ectodermal Dysplasia Ectodermal Dysplasia, Hypohidrotic, Autosomal Dominant Hypohidrotic Ectodermal Dysplasia Autosomal Dominant Ad-Hed Autosomal Dominant Anhidrotic Ectodermal Dysplasia Ectodermal Dysplasia 3 Ed3 Eda3 Ectodermal Dysplasia, Anhidrotic, Autosomal Dominant Dysplasia, Ectodermal, Type 10a, Hypohidrotic/Hair/Nail, Autosomal Dominant Dysplasia, Ectodermal, Type 3
Frontometaphyseal Dysplasia	Fmd Dysplasia, Frontometaphyseal
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Noonan Syndrome 1	Noonan Syndrome NS1 Male Turner Syndrome Female Pseudo-Turner Syndrome Turner Phenotype With Normal Karyotype Noonan Syndrome With Pigmented Villonodular Synovitis Turner'S Phenotype, Karyotype Normal Familial Turner Syndrome Noonan'S Syndrome Noonan-Ehmke Syndrome Ns Pseudo-Ullrich-Turner Syndrome Turner Syndrome In Female With X Chromosome Turner-Like Syndrome Ullrich-Noonan Syndrome Noonan-Like/Multiple Giant Cell Lesion Syndrome Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions Pterygium Colli Syndrome Noonan Syndrome, Type 1 Turner Syndrome, Male

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N2435	[8]-Shogaol		99.93%	Unkown
HY-114454	INH14	Inhibitor	98.0%	Unkown
HY-167704	NF023		/	Unkown
HY-RS14133	TAB1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19961	Tab1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26463	Tab1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TAB1	VGNC	VGNC:58447
Mus musculus	TAB1	MGD	MGI:1913763
Canis familiaris	TAB1	VGNC	VGNC:54550
Rattus norvegicus	TAB1	RGD	RGD:1306216
Macaca mulatta	TAB1	VGNC	VGNC:84536
Others	TAB1	NCBI