3-Amino-1-adamantanol
Based on 1 Customer Validation
3-Amino-1-adamantanol is a p38α‑TAB1 interaction inhibitor. 3-Amino-1-adamantanol occupies the non-canonical docking site of p38α, inhibits the phosphorylation of TAB1 by activated pp38α, and disrupts the formation of the p38α‑TAB1 protein complex. 3-Amino-1-adamanol is applicable to research related to myocardial ischemic injury; it also serves as an intermediate for the synthesis of compounds such as Vildagliptin (HY-14291).
For research use only. We do not sell to patients.
- CAS No.: 702-82-9
- Formula: C10H17NO
- Molecular Weight:167.25
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Storage:
RT, protect from light.
In solvent -80°C, 1 year , -20°C, 6 months
Biological Activity
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p38α |
3-Amino-1-adamantanol (12.5 mM) binds recombinant p38α independently of the ATP-binding pocket, increasing the melting temperature of this protein by 3.1°C; it inhibits the phosphorylation modification of recombinant TAB1 (residues 1-438) by recombinant active pp38α[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 702-82-9
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Appearance Solid
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Molecular Weight 167.25
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Formula C10H17NO
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Color White to off-white
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SMILES
O[C@]1(C2)C[C@@H]3C[C@@H](C[C@@]2(N)C3)C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
RT, protect from light
In solvent -80°C 1 year -20°C 6 months
Purity & Documentation
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Data Sheet (271 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)