1. Metabolic Enzyme/Protease
    Apoptosis
  2. Dipeptidyl Peptidase
    Ferroptosis
    Apoptosis
  3. Vildagliptin

Vildagliptin (Synonyms: LAF237; NVP-LAF 237)

Cat. No.: HY-14291 Purity: 98.18%
Handling Instructions

Vildagliptin (LAF237) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC50 of 3.5 nM in human Caco-2 cells. Vildagliptin possesses excellent oral bioavailability and potent antihyperglycemic activity.

For research use only. We do not sell to patients.

Vildagliptin Chemical Structure

Vildagliptin Chemical Structure

CAS No. : 274901-16-5

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Customer Review

Based on 3 publication(s) in Google Scholar

Other Forms of Vildagliptin:

Top Publications Citing Use of Products

    Vildagliptin purchased from MCE. Usage Cited in: Cancer Lett. 2018 Apr 28;420:26-37.

    Representative images showing visible metastatic nodules in the lungs of mice treated with Vildagliptin and fed an high-fat diet (HFD).
    • Biological Activity

    • Purity & Documentation

    • References

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    Description

    Vildagliptin (LAF237) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC50 of 3.5 nM in human Caco-2 cells. Vildagliptin possesses excellent oral bioavailability and potent antihyperglycemic activity[1].

    IC50 & Target

    IC50: 3.5 nM (DPP-IV, in human Caco-2 cells)[1]

    In Vitro

    Vildagliptin promotes beta cell survival by inhibiting cell apoptosis. Vildagliptin also promotes cell proliferation[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    In Vivo

    Vildagliptin (35 mg/kg; once daily by oral gavage) increases plasma active GLP-1 levels in islets of db/db mice[2].
    Vildagliptin (10 µmol/kg; orally) significantly decreases glucose excursions and stimulate insulin secretion in obese male Zucker rats[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Male db/db mice (BKS) and wildtype mice[2]
    Dosage: 35 mg/kg
    Administration: Oral gavage; once daily; for 6 weeks
    Result: Increased plasma active GLP-1 levels (22.63±1.19 vs. 11.69±0.44).
    Animal Model: Obese male Zucker rats[1]
    Dosage: 10 µmol/kg (Pharmacokinetic Analysis)
    Administration: Orally
    Result: Significantly decreased glucose excursions and stimulate insulin secretion.
    Clinical Trial
    Molecular Weight

    303.40

    Formula

    C₁₇H₂₅N₃O₂

    CAS No.
    SMILES
    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    H2O : 50 mg/mL (164.80 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.2960 mL 16.4799 mL 32.9598 mL
    5 mM 0.6592 mL 3.2960 mL 6.5920 mL
    10 mM 0.3296 mL 1.6480 mL 3.2960 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Vildagliptin is added to drinking water at a concentration of 150 mg/L for rats or 300 mg/L for mice[4].

    References
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    Keywords:

    VildagliptinLAF237 NVP-LAF 237LAF 237LAF-237Dipeptidyl PeptidaseFerroptosisApoptosisDPPdipeptidylpeptidaseDPP-IVCaco-2cellsantihyperglycemicInhibitorinhibitorinhibit

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    Product Name:
    Vildagliptin
    Cat. No.:
    HY-14291
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