1. Metabolic Enzyme/Protease Apoptosis
  2. Dipeptidyl Peptidase Ferroptosis Apoptosis
  3. Vildagliptin

Vildagliptin  (Synonyms: LAF237; NVP-LAF 237)

Cat. No.: HY-14291 Purity: 99.61%
COA Handling Instructions

Vildagliptin (LAF237) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC50 of 3.5 nM in human Caco-2 cells. Vildagliptin possesses excellent oral bioavailability and potent antihyperglycemic activity.

For research use only. We do not sell to patients.

Vildagliptin Chemical Structure

Vildagliptin Chemical Structure

CAS No. : 274901-16-5

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in Water
ready for reconstitution
USD 61 In-stock
Solution
10 mM * 1 mL in Water USD 61 In-stock
Solid
5 mg USD 35 In-stock
10 mg USD 55 In-stock
50 mg USD 77 In-stock
100 mg USD 110 In-stock
500 mg USD 154 In-stock
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Customer Review

Based on 6 publication(s) in Google Scholar

Other Forms of Vildagliptin:

Top Publications Citing Use of Products

    Vildagliptin purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2022, 23(22), 14101

    qPCR Assay. Vildagliptin (5 µM; 0, 6, 12, 24, 48, 72 h) stimulates the expression of IL-6 in HaCaT cells.

    Vildagliptin purchased from MedChemExpress. Usage Cited in: Cancer Lett. 2018 Apr 28;420:26-37.  [Abstract]

    Representative images showing visible metastatic nodules in the lungs of mice treated with Vildagliptin and fed an high-fat diet (HFD).

    View All Dipeptidyl Peptidase Isoform Specific Products:

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Vildagliptin (LAF237) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC50 of 3.5 nM in human Caco-2 cells. Vildagliptin possesses excellent oral bioavailability and potent antihyperglycemic activity[1].

    IC50 & Target

    IC50: 3.5 nM (DPP-IV, in human Caco-2 cells)[1]

    In Vitro

    Vildagliptin promotes beta cell survival by inhibiting cell apoptosis. Vildagliptin also promotes cell proliferation[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    In Vivo

    Vildagliptin (35 mg/kg; once daily by oral gavage) increases plasma active GLP-1 levels in islets of db/db mice[2].
    Vildagliptin (10 µmol/kg; orally) significantly decreases glucose excursions and stimulate insulin secretion in obese male Zucker rats[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Male db/db mice (BKS) and wildtype mice[2]
    Dosage: 35 mg/kg
    Administration: Oral gavage; once daily; for 6 weeks
    Result: Increased plasma active GLP-1 levels (22.63±1.19 vs. 11.69±0.44).
    Animal Model: Obese male Zucker rats[1]
    Dosage: 10 µmol/kg (Pharmacokinetic Analysis)
    Administration: Orally
    Result: Significantly decreased glucose excursions and stimulate insulin secretion.
    Clinical Trial
    Molecular Weight

    303.40

    Formula

    C17H25N3O2

    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O[C@@]1(C2)C[C@H]3C[C@H](C[C@]2(NCC(N4[C@H](C#N)CCC4)=O)C3)C1

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 2 years
    -20°C 1 year
    Solvent & Solubility
    In Vitro: 

    H2O : 50 mg/mL (164.80 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.2960 mL 16.4799 mL 32.9598 mL
    5 mM 0.6592 mL 3.2960 mL 6.5920 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

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    In Vivo:

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 100 mg/mL (329.60 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

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    (per animal)

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    Dosing volume
    (per animal)

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    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 3.2960 mL 16.4799 mL 32.9598 mL 82.3995 mL
    5 mM 0.6592 mL 3.2960 mL 6.5920 mL 16.4799 mL
    10 mM 0.3296 mL 1.6480 mL 3.2960 mL 8.2399 mL
    15 mM 0.2197 mL 1.0987 mL 2.1973 mL 5.4933 mL
    20 mM 0.1648 mL 0.8240 mL 1.6480 mL 4.1200 mL
    25 mM 0.1318 mL 0.6592 mL 1.3184 mL 3.2960 mL
    30 mM 0.1099 mL 0.5493 mL 1.0987 mL 2.7466 mL
    40 mM 0.0824 mL 0.4120 mL 0.8240 mL 2.0600 mL
    50 mM 0.0659 mL 0.3296 mL 0.6592 mL 1.6480 mL
    60 mM 0.0549 mL 0.2747 mL 0.5493 mL 1.3733 mL
    80 mM 0.0412 mL 0.2060 mL 0.4120 mL 1.0300 mL
    100 mM 0.0330 mL 0.1648 mL 0.3296 mL 0.8240 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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