1. Metabolic Enzyme/Protease
    Apoptosis
  2. Dipeptidyl Peptidase
    Ferroptosis
    Apoptosis
  3. Vildagliptin dihydrate

Vildagliptin dihydrate (Synonyms: LAF237 dihydrate; NVP-LAF 237 dihydrate)

Cat. No.: HY-14291A
Handling Instructions

Vildagliptin dihydrate (LAF237 dihydrate) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC50 of 3.5 nM in human Caco-2 cells. Vildagliptin dihydrate possesses excellent oral bioavailability and potent antihyperglycemic activity.

For research use only. We do not sell to patients.

Vildagliptin dihydrate Chemical Structure

Vildagliptin dihydrate Chemical Structure

CAS No. : 2133364-01-7

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Top Publications Citing Use of Products

    Vildagliptin dihydrate purchased from MCE. Usage Cited in: Cancer Lett. 2018 Apr 28;420:26-37.

    Representative images showing visible metastatic nodules in the lungs of mice treated with Vildagliptin and fed an high-fat diet (HFD).
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    Description

    Vildagliptin dihydrate (LAF237 dihydrate) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC50 of 3.5 nM in human Caco-2 cells. Vildagliptin dihydrate possesses excellent oral bioavailability and potent antihyperglycemic activity[1].

    IC50 & Target

    IC50: 3.5 nM (DPP-IV, in human Caco-2 cells)[1]

    In Vitro

    Vildagliptin promotes beta cell survival by inhibiting cell apoptosis. Vildagliptin also promotes cell proliferation[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    In Vivo

    Vildagliptin (35 mg/kg; once daily by oral gavage) increases plasma active GLP-1 levels in islets of db/db mice[2].
    Vildagliptin (10 µmol/kg; orally) significantly decreases glucose excursions and stimulate insulin secretion in obese male Zucker rats[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Male db/db mice (BKS) and wildtype mice[2]
    Dosage: 35 mg/kg
    Administration: Oral gavage; once daily; for 6 weeks
    Result: Increased plasma active GLP-1 levels (22.63±1.19 vs. 11.69±0.44).
    Animal Model: Obese male Zucker rats[1]
    Dosage: 10 µmol/kg (Pharmacokinetic Analysis)
    Administration: Orally
    Result: Significantly decreased glucose excursions and stimulate insulin secretion.
    Clinical Trial
    Molecular Weight

    339.43

    Formula

    C₁₇H₂₉N₃O₄

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    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.

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    Keywords:

    Vildagliptin dihydrateLAF237 dihydrate NVP-LAF 237 dihydrateDipeptidyl PeptidaseFerroptosisApoptosisDPPdipeptidylpeptidaseDPP-IVCaco-2cellsantihyperglycemicInhibitorinhibitorinhibit

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