DPP-4

DPP-4 (DPP IV) belongs to the family of serine proteases, comprising of 766 amino acids. It is composed of a 6-amino-acid cytoplasmic tail, a transmembrane domain of 22-amino-acids, and a large extracellular domain. The extracellular domain is responsible for ligand binding and for DPP-4 activity. DPP-4 is a soluble plasma enzyme expressed in high levels in the capillary bed of the gut mucosa, some immune cells like T cells and epithelial cells. DPP-4 is also expressed in other organs such as the liver, the intestine, the kidney and the lungs. The imprecise expression of soluble DPP-4 leads to many biological disorders including solid tumors, diabetes mellitus (type-2), obesity, autoimmune diseases and hepatitis.Dipeptidyl peptidase IV is well known for its role in glucose homeostasis. It has become a validated therapeutic target for the treatment of type 2 diabetes (T2D).

DPP-4 Inhibitors (17)

DPP-4 Related Products (18):

By Type:	Selective (7)

Cat. No.	Product Name	Effect	Purity

HY-13749

Sitagliptin	Inhibitor	99.72%
Sitagliptin (MK-0431) is a potent inhibitor of DPP4 with an IC₅₀ of 19 nM in Caco-2 cell extracts.

HY-10285

Saxagliptin	Inhibitor	99.96%
Saxagliptin (BMS-477118) is a potent, selective, reversible, competitive and orally active dipeptidyl peptidase-4 (DPP-4) (K_i = 0.6-1.3 nM) inhibitor.

HY-14877

Anagliptin	Inhibitor
Anagliptin (SK-0403) is a highly selective, potent, orally active inhibitor of dipeptidyl peptidase 4 (DPP-4), with an IC₅₀ of 3.8 nM, and less selective at DPP-8 and DDP-9 with IC₅₀s of 68 nM and 60 nM, respectively.

HY-13749A

Sitagliptin phosphate	Inhibitor	99.98%
Sitagliptin phosphate (MK-0431 phosphate) is a potent inhibitor of DPP4 with an IC₅₀ of 19 nM in Caco-2 cell extracts.

HY-117985B

Evogliptin tartrate	Inhibitor	99.96%
Evogliptin (DA-1229) tartrate is an orally active DPP4 inhibitor with significant and sustained hypoglycaemic effects in mouse models.

HY-123377

Fotagliptin	Inhibitor
Fotagliptin is a Dipeptidyl Peptidase IV (DPP-4) inhibitor (IC₅₀=2.27 nM).

HY-123377A

Fotagliptin benzoate	Inhibitor
Fotagliptin benzoate is a Dipeptidyl Peptidase IV (DPP-4) inhibitor (IC₅₀=2.27 nM).

HY-P1230

HAEGT		99.26%
HAEGT is the first N-terminal 1-5 residues of glucagon like peptide-1 (GLP-1) peptide, and the sequence is His-Ala-Glu-Gly-Thr.

HY-147401

Sitagliptin fenilalanil	Inhibitor
Sitagliptin fenilalanil is a dipeptidyl aminopeptidase 4 (DPP-4) inhibitor.

HY-14877A

Anagliptin hydrochloride	Inhibitor
Anagliptin (SK-0403) hydrochloride is a highly selective, potent, orally active inhibitor of dipeptidyl peptidase 4 (DPP-4), with an IC₅₀ of 3.8 nM, and less selective at DPP-8 and DDP-9 with IC₅₀s of 68 nM and 60 nM, respectively.

HY-13749C

(S)-Sitagliptin phosphate	Inhibitor
(S)-Sitagliptin phosphate is the less active S-enantiomer of Sitagliptin phosphate.

HY-146455

DPP-4-IN-3	Inhibitor
DPP-4-IN-3 (Compound 5a) is a potent dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC₅₀ of 0.75 nM.

HY-151383

DPP-4-IN-1	Inhibitor
DPP-4-IN-1 (compound d1) is a potent DPP-4 (dipeptidyl peptidase 4) inhibitor, with an IC₅₀of 49 nM.

HY-103433

K579	Inhibitor
K579 is a potent and orally active dipeptidyl peptidase IV inhibitor.

HY-151384

DPP-4-IN-2	Inhibitor
DPP-4-IN-2 (compound b2) is a potent DPP-4 (dipeptidyl peptidase 4) inhibitor, with an IC₅₀of 79 nM.

HY-14806S

Teneligliptin-d₈	Inhibitor
Teneligliptin D8 (MP-513 D8) a deuterium labeled Teneligliptin (MP-513).

HY-129736

P32/98 hemifumarate	Inhibitor
P32/98 hemifumarateis a potent inhibitor of dipeptidyl peptidase IV with a K_i value of 130 nM.

HY-10285A

Saxagliptin hydrate	Inhibitor
Saxagliptin hydrate (BMS-477118 hydrate) is a potent, selective, reversible, competitive and orally active dipeptidyl peptidase-4 (DPP-4) (K_i = 0.6-1.3 nM) inhibitor.

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